The European physics laboratory CERN is planning to build a mega collider by 2070. Critics say the plan could lead to ruin
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Klein bottle
Posted in evolution, space | Leave a Comment on Klein bottle
Suppose for clarification that we adopt time as that fourth dimension. Consider how the figure could be constructed in xyzt-space. The accompanying illustration (“Time evolution…”) shows one useful evolution of the figure. At t = 0 the wall sprouts from a bud somewhere near the “intersection” point. After the figure has grown for a while, the earliest section of the wall begins to recede, disappearing like the Cheshire Cat but leaving its ever-expanding smile behind. By the time the growth front gets to where the bud had been, there is nothing there to intersect and the growth completes without piercing existing structure. The 4-figure as defined cannot exist in 3-space but is easily understood in 4-space. [ 4 ]
More formally, the Klein bottle is the quotient space described as the square [0,1] × [0,1] with sides identified by the relations (0, y) ~ (1, y) for 0 ≤ y ≤ 1 and (x, 0) ~ (1 − x, 1) for 0 ≤ x ≤ 1.
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They found that increased Hh signaling is a hallmark of human meibomian gland carcinoma, a rare and aggressive cancer of the eyelid. Furthermore, the team discovered that aged glands show decreased Hh signaling and decreased epidermal growth factor receptor (EGFR) signaling, as well as impaired innervation and a loss of collagen in niche fibroblasts, suggesting that changes in both glandular epithelial cells and their surrounding microenvironment contribute to age-related degeneration.
These discoveries suggest that targeting Hh and EGFR signaling to stimulate stem cell activity in the meibomian glands could be a potential therapeutic option to treat evaporative dry eye disease.
A team of researchers has identified stem cell populations and mechanisms underlying age-related degeneration in glands that are vital to eye function. The findings, published in Nature Communications, may lead to new therapeutic approaches for evaporative dry eye disease, a common condition in older people.
Meibomian glands, tiny oil glands along the edges of the eyelids, secrete lipid-rich meibum to prevent tear evaporation and protect the eye surface. Aging-related shrinkage of the meibomian glands may result, in part, from stem cell exhaustion and is associated with evaporative dry eye disease, a common condition that causes swollen eyelids, itchy eyes, or blurred vision. Symptoms may be lessened with warm compressions, artificial tears, and thermal pulsation, but these treatments are only partially effective.
The researchers identified markers for stem cell populations that maintain distinct regions of the meibomian glands, and uncovered the hedgehog (Hh) cell-cell signaling pathway, which is broadly important in development and disease, as a key regulator of meibomian gland stem cell proliferation and tissue regeneration.
Reelin is a critical mechanistic link between neuronal activation and cocaine-induced behavioral adaptations.
UCLA Health researchers have helped to develop a new digital toolbox to create a “common language” for brain network studies, potentially accelerating new discoveries and treatments for neurological and psychiatric conditions.
In a study recently published in the journal Nature Communications, the authors say the open-source software will help researchers worldwide overcome a longstanding hurdle in brain imaging research.
“As long as people have been interested in studying the brain, they have tried to map it out by answering a basic question: how many brain regions are there?” said study senior author Lucina Uddin, a UCLA Health Psychiatry and Biobehavioral Sciences Professor and Director of the UCLA Brain Connectivity and Cognition Laboratory.
This cohort study examines the incidence and proportion of interval cancer and screen-detected breast cancer and identifies factors associated with interval cancer.
An intense x-ray pulse from a free-electron laser sends a protein’s atoms flying off in directions that reveal the protein’s structure.
Experiments with erbium ions show that they can be used to create entangled photons in the telecom band—an important step in building quantum repeaters.