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Year 2024 😗

Modular tiles, 3D printed using sawdust leftover from CLT production, were joined together without additional fixings to create this pavilion showcased by Japanese firm Mitsubishi Jisho Design at Dubai Design Week.

The Warp is a teahouse pavilion developed by architects Kei Atsumi and Motoya Iizawa from Mitsubishi Jisho Design’s Tokyo headquarters, along with Singapore-based Vibha Krishna Kumar from Mitsubishi Jisho Design Asia.

The project showcases a production system developed by the architecture firm called Regenerative Wood, which uses a filament made from wood waste mixed with bioplastic to 3D print building components and furniture.

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Year 2024 In The advent of advanced architectural buildings wanting to be more sustainable we could have 3D printed wood waste buildings that are as strong as steel and even fireproof even where the glass is made from transparent wood.

The new tower would be double the height of the current record-holder—that’s also in Milwaukee.

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Basically fungi foods can cure nearly all diseases it just requires the right mushroom for the ailment.

Bioactive compounds and metabolites in mushrooms Mushrooms in ancient healing Edible mushrooms with therapeutic potency References Further reading

Fungi have gained significant attention in the field of phytomedicine as potential natural sources of bioactive compounds and secondary metabolites. Fungi that produce visible fruiting bodies are called macrofungi. Mushrooms are edible macrofungi mainly found in rainy and snow-melting seasons.

Mushrooms form macroscopic fruiting bodies that eventually produce and disperse spores. Mushroom spores contain all the essential components that are needed to produce a new fungus. Mushrooms can exist in nature in many forms, including leathery or woody, fleshy, or sub-fleshy forms.

Mushrooms are probably the most miraculous entities because each mushroom can aid in a different way to cure each illness in the human biology. Much like cannabis is actually a cure all for so many ailments in humans so in turn are mushrooms able to do the same.

Alzheimer’s disease (AD) stands as a formidable neurodegenerative ailment and a prominent contributor to dementia. The scarcity of available therapies for AD accentuates the exigency for innovative treatment modalities. Psilocybin, a psychoactive alkaloid intrinsic to hallucinogenic mushrooms, has garnered attention within the neuropsychiatric realm due to its established safety and efficacy in treating depression. Nonetheless, its potential as a therapeutic avenue for AD remains largely uncharted. This comprehensive review endeavors to encapsulate the pharmacological effects of psilocybin while elucidating the existing evidence concerning its potential mechanisms contributing to a positive impact on AD. Specifically, the active metabolite of psilocybin, psilocin, elicits its effects through the modulation of the 5-hydroxytryptamine 2A receptor (5-HT2A receptor). This modulation causes heightened neural plasticity, diminished inflammation, and improvements in cognitive functions such as creativity, cognitive flexibility, and emotional facial recognition. Noteworthy is psilocybin’s promising role in mitigating anxiety and depression symptoms in AD patients. Acknowledging the attendant adverse reactions, we proffer strategies aimed at tempering or mitigating its hallucinogenic effects. Moreover, we broach the ethical and legal dimensions inherent in psilocybin’s exploration for AD treatment. By traversing these avenues, We propose therapeutic potential of psilocybin in the nuanced management of Alzheimer’s disease.

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is the leading cause of dementia in the elderly population (Anonymous, 2021). It is characterized by the deposition of amyloid-beta (AÎČ) plaques, tau neurofibrillary tangles, and neuroinflammation (Scheltens et al., 2021). The prevalence of dementia is expected to rise as the global population grows and ages, with projections estimating a significant increase in the number of cases (Anonymous, 2022b). In 2019, the total cost of healthcare, long-term care, and hospice services for individuals aged 65 years and older with dementia in the United States was estimated at $2.2billion, so AD imposes a substantial burden on individuals, families, society, and the economy (Anonymous, 2022a). The U.S. Food and Drug Administration (FDA) has approved seven drugs for the treatment of AD, including rivastigmine, donepezil, galantamine, memantine, memantine combined with donepezil, aducanumab and lecanemab.

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Professor JosĂ© R PenadĂ©s told the BBC that Google’s tool reached the same hypothesis that his team had – that superbugs can create a tail that allows them to move between species. In simpler terms, one can think of it as a master key that enables the bug to move from home to home.

PenadĂ©s asserts that his team’s research was unique and that the results hadn’t been published anywhere online for the AI to find. What’s more, he even reached out to Google to ask if they had access to his computer. Google assured him they did not.

Arguably even more remarkable is the fact that the AI provided four additional hypotheses. According to Penadés, all of them made sense. The team had not even considered one of the solutions, and is now investigating it further.

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Many aspects of inflammation increase with aging in mice and humans. Transcriptomic analysis revealed that many murine anti-aging interventions produce lower levels of pro-inflammatory proteins. Here, we explore the hypothesis that different longevity interventions diminish NF-ÎșB levels, potentially mediating some of the anti-inflammatory benefits of lifespan-extending interventions. We found that the NF-ÎșB protein p65 is significantly downregulated in the liver of several kinds of slow-aging mice. These included both sexes of GHRKO and Snell Dwarf mutant mice, and in females only of PAPPA KO mice. P65 is also lower in both sexes of mice treated with rapamycin, canagliflozin, meclizine, or acarbose, and in mice undergoing caloric restriction. Two drugs that extend lifespan of male mice, i.e. 17α-estradiol and astaxanthin, however, did not produce lower levels of p65.

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In a development for artificial intelligence, researchers have unveiled a synaptic device array that shows promise for enhancing artificial visual systems. This innovative array, measuring a compact 0.7 × 0.7 cm2, integrates the capabilities of sensing, memory, and processing to mimic the intricate functions of the human visual system.

Utilizing wafer-scale monolayer molybdenum disulfide (MoS2) and for enhanced electron capture, the array exhibits remarkable coordination between optical and electrical components. It is capable of both writing and erasing images and has achieved a 96.5% accuracy in digit recognition, marking a significant leap forward in the development of large-scale neuromorphic systems.

The human visual system processes complex visual data efficiently through an interconnected network that allows for parallel processing. However, current artificial vision systems face numerous challenges, including circuit complexity, high power consumption, and difficulties in miniaturization.

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