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Common mucus-clearing treatments don’t help ICU patients breathe easier and may cause harm, clinical trial finds

For patients struggling to breathe because of acute respiratory failure, clearing mucus from the airways is a routine part of treatment. Mucoactive agents are widely used for this purpose. But after years of clinical use, one question remains: Do mucoactive agents actually help?

To figure this out, researchers designed a large study called the MARCH (Mucoactives in Acute Respiratory Failure: Carbocisteine and Hypertonic Saline) randomized trial, which included nearly 2,000 adults across 71 hospitals in the United Kingdom who were on ventilators and having trouble clearing mucus. The focus of the study was to determine the effectiveness of two widely used mucoactive agents: carbocisteine and hypertonic saline (HTS).

The drugs did not deliver the hoped-for benefits. Those who were on carbocisteine spent about the same amount of time on the ventilator as those who didn’t get any treatment, and the same was true for HTS. Instead, the medications appeared to do more harm than good. Patients treated with these mucoactive agents had side effects like bleeding in the stomach, tightened airways and a drop in blood oxygen levels.

Human red blood cells form without central ‘hub’ seen in mouse models, upending understanding of our physiology

Northwestern Medicine scientists have discovered that one of the body’s most fundamental biological processes—how red blood cells are made—works differently in humans than previously thought, according to a new study published in Nature Genetics. The findings overturn decades of assumptions based largely on animal research, said study senior author Peng Ji, MD, Ph.D., the Marie A. Fleming Research Professor of Pathology.

In the study, Ji and his collaborators used advanced spatial mapping tools to directly observe microscopic environments, known as erythroblastic islands (EBIs), inside intact tissues. EBIs have long been understood to act as “nurseries” where red blood cells mature. But until now, scientists lacked a clear picture of what these structures look like in humans.

“For decades, our understanding of these structures has come almost entirely from mouse studies,” said Ji, who is also vice chair for research in the Department of Pathology. “Most experiments relied on isolating cells and studying them in flat, two-dimensional systems, which disrupt their native organization.”

A COF-graphene hybrid opens new horizons for lithium-sulfur batteries

Lithium-sulfur (Li-S) batteries combine the abundance and affordability of sulfur with an energy storage capability far beyond that of current lithium-ion technologies. Practical deployment, however, has been slowed by a longstanding challenge known as polysulfide shuttling, whereby dissolved sulfur intermediates migrate within the battery, leading to active-material loss and premature performance decay.

Now, researchers from Tohoku University and collaborating institutions have tackled this problem by developing a molecularly designed covalent organic framework (COF)-graphene interlayer. This lightweight interface mitigates polysulfide shuttling by combining chemical trapping, rapid charge transport and sulfur-conversion promotion.

The work was published in the journal Small.

Two prostate cancer mutations reveal opposite responses to ferroptosis therapy

A new study by researchers at The University of Texas MD Anderson Cancer Center has identified genetic factors that determine whether prostate cancers are susceptible to a type of cell death known as ferroptosis. These findings, published in Nature Communications, could help guide treatment strategies for patients whose tumors do not respond to current treatment options.

The study was led by Di Zhao, Ph.D., associate professor, and Boyi Gan, Ph.D., professor, both of Experimental Radiation Oncology.

“Prostate cancer is such a genetically diverse cancer that there are many possible treatment options, so getting patients on the right treatment as quickly as possible is crucially important,” Zhao said. “The two genetic findings in this study could help identify some patients who are more likely to respond, as well as some patients who are significantly less likely.”

The world’s first ultra-compact semiconductor chip for biosignal measurement

A research team led by Prof. Junghyup Lee of the Department of Electrical Engineering and Computer Science at DGIST has become the first in the world to develop a “time-interleaved noise-shaping SAR ADC (analog-to-digital converter)” semiconductor chip capable of simultaneously measuring multiple biosignals, including electrocardiograms (ECG) and electromyograms (EMG). The team developed this technology in an actual semiconductor chip and successfully completed functional validation. Their findings were presented at the IEEE Symposium on VLSI Technology & Circuits (VLSI 2026), held in Honolulu, June 14–18.

Accurately measuring multiple biosignals using wearable devices such as smartwatches requires meeting several demanding conditions. These include “ultra-high input impedance (resistance)” to prevent signal loss even when no sweat is present on the skin or when contact is loose (dry or non-contact electrodes), a “wide input range” to prevent signal distortion caused by vigorous movement, and “ultra-low power consumption” for long-term operation. However, conventional measurement approaches have struggled to satisfy all these requirements simultaneously within a single chip.

Lee’s research team addressed this challenge by proposing a novel “time-interleaved third-order noise-shaping SAR ADC” architecture in which circuit blocks that consume significant power and chip area are shared across multiple channels, while only essential components (the residual capacitor banks) are allocated separately to each channel. This approach dramatically reduced the circuit area and power consumption required for multichannel systems, enabling an ultra-compact, ultra-low-power chip.

Common nanostructures may explain shared photoproperties in two widespread dark materials

A newly developed framework for understanding the photoproperties of both natural organic matter and eumelanin, a natural pigment responsible for dark colors in organisms, may inspire advanced sustainable technologies, scientists say.

Although they are some of the most widespread substances on Earth, not much is known about eumelanin or natural organic matter (NOM)—a dark-colored substance formed by the decomposition of biological material. In humans, eumelanin is a vital pigment in skin and other tissues that protects cells from damage caused by ultraviolet radiation. In nature, NOM gives rivers and soils their color and affects light-driven reactions like photosynthesis.

Although these compounds have been studied individually for decades, researchers in a new study, by scrutinizing them alongside each other, have shown that eumelanin and NOM have common properties beyond their dark colors.

Brainwide blood volume reflects opposing neural populations

An interesting new approach to more accurately predicting blood flow in the mouse brain based on the activity of neurons correlated positively or negatively with arousal (as measured by whisking). Neuropixels and functional ultrasound imaging were used to simultaneously record from neurons and map blood flow, allowing the authors to derive their model.

Combined functional ultrasound imaging and Neuropixels recording of mouse brains identify two neuronal populations with opposing arousal-related activity and distinct haemodynamic response functions, that occur throughout the brain.

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