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Global density and biomass of arbuscular mycorrhizal fungal networks

Arbuscular mycorrhizal fungi form symbioses with ~70% of plant species, building hyphal networks that exchange nutrients for host-derived carbon. These tubular networks move ~1 billion metric tons of carbon per year into Earth’s soils. However, we have no quantitative understanding of the hyphal infrastructure required to carry out this resource transfer. We assembled data from 322 studies representing more than 16,000 soil cores across nine biomes and developed machine-learning models to predict hyphal densities globally. With robotic imaging of more than 300,000 hyphae, we calibrated a biomass model from our spatial predictions. We estimate that global topsoils contain 1.10 × 1017 ± 0.13 × 1017 SD kilometers of living hyphae, weighing ~300 ± 60 SD megatons, ~4-to 6-fold the biomass of humans.

Method for stress-testing cloud computing algorithms helps avoid network failures

This new approach can identify worse-case scenarios that an engineer might miss if they use a traditional method that compares an algorithm against a set of human-designed past test cases. It is also less labor-intensive than other verification tools that require engineers to rewrite an algorithm in a complex mathematical code each time they want to test it.

Instead of needing a mathematical reformulation, the new method reads the algorithm’s source code directly and automatically searches for worse-case scenarios that lead to the highest level of underperformance.

By helping engineers quickly and easily stress-test a networking algorithm before deployment, the method could catch failure modes that might otherwise only appear in a real outage. The technique could also be used to analyze the risks of deploying AI-generated code.

Bacteria’s ‘mix-and-match’ code could create new cancer-fighting drugs

A team of researchers at the University of Warwick and Monash University has solved a puzzle that has stumped drug developers for decades: how bacteria naturally create multiple versions of powerful cancer therapies. The breakthrough could accelerate the development of new treatments for hard-to-treat cancers.

Harnessing bacterial enzymes to create drug variants, a strategy known as combinatorial biosynthesis, has long been a goal for scientists. But without understanding how these enzymes interact, progress has stalled.

Published in Nature Communications, the researchers have finally revealed how bacterial enzymes communicate and work together to assemble a family of related anticancer compounds. This family includes romidepsin (Istodax), a clinically approved blood cancer treatment. By understanding this “mix-and-match” process and replicating the principle in the lab, the researchers have established an approach to designing new therapies.

Robotic bird helps uncover the mysteries of flight turbulence

A bio-inspired robotic bird capable of mimicking the key movements of kestrels is helping researchers unravel the mysteries behind the species’ exceptional hovering capabilities.

With atmospheric turbulence expected to worsen due to climate change, understanding how birds naturally cope with rough air could help engineers design small unmanned aerial vehicles that are safer, more efficient and fly more smoothly.

Small unmanned aerial vehicles (sUAVs) are commonly used for applications including aerial photography, search and rescue, agricultural monitoring and package delivery, but are often grounded in turbulent conditions.

Microstructure-based model predicts sheet metal behavior in seconds for car and battery design

A research team led by Kyung Mun Min and Seonghwan Choi of Materials Processing Research Division (Korea Institute of Materials Science) has developed a new analysis model capable of predicting the anisotropic mechanical behavior of sheet metals within seconds using only microstructural information of metallic materials.

The technology is expected to reduce the time and cost required to design forming processes for metallic materials used in automobiles and batteries by enabling fast, accurate prediction of how sheet metals stretch and deform without complex, repetitive experiments.

The study is published in the International Journal of Plasticity.

Haptoglobin phenotypes and structural variants associate with post-exertional malaise and cognitive dysfunction in myalgic encephalomyelitis

Myalgic encephalomyelitis (ME) is a chronic, multisystem illness characterized by post-exertional malaise (PEM) and cognitive dysfunction, yet the molecular mechanisms driving these hallmark symptoms remain unclear. This study investigated haptoglobin (Hp) as a potential biomarker of PEM severity and cognitive impairment in ME, with a focus on Hp phenotypes and structural proteoforms.

A longitudinal case–control study was conducted in 140 ME patients and 44 matched sedentary healthy controls. In the discovery phase, global plasma proteomic profiling was performed in 61 ME patients and 20 controls before and after a standardized, non-invasive stress protocol in order to induce PEM. Associations between Hp levels, phenotype, and cognitive performance were assessed. In the validation phase, plasma Hp concentrations and proteoform composition were analyzed in an independent cohort of 89 ME patients and 24 controls using high-performance liquid chromatography (HPLC).

ME patients demonstrated a significant reduction in Hp levels following post-exertional stress. Lower baseline Hp concentrations were associated with impaired cognitive performance. Hp phenotypes were differentially associated with symptom burden, with the Hp2-1 phenotype enriched in ME and linked to greater PEM severity and cognitive deficits compared to Hp1-1 and Hp2-2. HPLC analysis revealed altered Hp proteoform profiles in the Hp2-1 subgroup, including increased high-mass tetrameric and pentameric forms and shorter retention times indicative of structural changes. In contrast, the Hp1-1 phenotype was associated with milder symptoms and greater cognitive resilience.

Nearby super-Earth emerges as a top target in the search for life

Researchers have pinpointed a super-Earth in the habitable zone of a nearby M-dwarf star only 18 light-years away. Sophisticated instruments detected the planet’s gentle tug on its star, hinting at a rocky world that could hold liquid water. Future mega-telescopes may be able to directly image it—something impossible today.

This microbe turns into a cannibalistic ‘Hulk’

A newly discovered microbe is like a mini version of the Hulk.

Euplotes gigatrox is a single-celled protist that resembles an insect. It grazes on bacteria and other tiny microbes. Sometimes a small number of the protists balloon into “supergiants” more than twice their regular size. The huge cells cannibalize their smaller, genetically identical brethren. The triggers for the change aren’t entirely clear, but it tends to happen when there is plenty of food, researchers reported May 14 in the Proceedings of the National Academy of Sciences.

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