An algorithm is a set of instructions for accomplishing a task. Every piece of code could be called an algorithm, but this book covers the more interesting bits. I chose the algorithms in this book for inclusion because they’re fast, or they solve interesting problems, or both. Here are some highlights:
Dr Keith Siew, one of the study authors, says, “Nobody really likes talking about death, even cell death, which is perhaps why the physiology of death is so poorly understood. And in a way necrosis is death. If enough cells die, then tissues die, then we die. The question is what would happen if we could pause or stop necrosis.”
“Necrosis remains one of the last frontiers in medicine – a common thread across aging, disease, space biology, and scientific progress itself,” adds Dr Carina Kern, lead author of the study.
Necrosis occurs when cells are overwhelmed by injury, infection, or stress. The process floods cells with calcium, disrupting vital functions and causing the cell to rupture. This sudden collapse spills toxic molecules into surrounding tissue, triggering inflammation and accelerating damage.
Pain is a profound and unresolved health challenge, and current interventions are not sufficient for safe and effective pain management. Bioelectronics presents solutions for monitoring the symptoms of pain and treating these symptoms in a targeted manner.
How sickle cell disease suppresses antitumor immunity.
Sickle cell disease (SCD) have a higher risk of developing certain cancers than the general population, but the mechanisms driving this increased risk remain unclear.
SCD inhibits CD8+ T cell function in the tumor microenvironment, potentially affecting cancer immunotherapy.
The researchers reveal that SCD alters the 3D genome architecture of CD8+ T cells, triggering ferroptosis and impairing antitumor response resulting in reduced expression of anti-ferroptotic genes, including SLC7A11 and hydrogen sulfide (H2S) biogenesis genes, thereby increasing susceptibility to ferroptosis.
They also demonstrate that hydrogen sulfide treatment rescued SLC7A11 expression, mitigated ferroptosis and enhanced immune and anti-tumor responses, thereby offering new avenues for precision immunotherapy in patients with inherited disorders. https://sciencemission.com/Sickle-cell-disease
Sickle cell disease (SCD) inhibits CD8+ T cell function in the tumor microenvironment, potentially affecting cancer immunotherapy. Zhao, Hu, Deng, et al. reveal that SCD alters the 3D genome architecture of CD8+ T cells, triggering ferroptosis and impairing anti-tumor responses, which can be reversed by hydrogen sulfide treatment, offering new avenues for precision immunotherapy in patients with inherited disorders.
Posted in neuroscience, science | Leave a Comment on Science: A new Science Advances study finds that male Aedes aegypti mosquitoes have more complex auditory processes than females of the species
A new Science Advances study finds that male Aedes aegypti mosquitoes have more complex auditory processes than females of the species.
Brain imaging identified more neuronal clusters of greater complexity in males, likely linked to male attraction to female flight tones.
A new study published in JAMA Psychiatry makes the case that symptom provocation may significantly improve the clinical effectiveness of repetitive transcranial magnetic stimulation (rTMS), a noninvasive brain stimulation method used to treat depression, obsessive-compulsive disorder (OCD) and nicotine dependence.
The study was conceptualized, designed and supervised by Heather Burrell Ward, MD, assistant professor of Psychiatry and Behavioral Sciences and director of Neuromodulation Research, in collaboration with Simon Vandekar, Ph.D., associate professor of Biostatistics and Daniel Bello and Megan Jones, two students in their respective labs.
This is the first large-scale meta-analysis to examine whether deliberately triggering symptoms immediately before administering rTMS enhances treatment outcomes.
When navigating a place that we’re only somewhat familiar with, we often rely on unique landmarks to help make our way. However, if we’re looking for an office in a brick building, and there are many brick buildings along our route, we might use a rule like looking for the second building on a street, rather than relying on distinguishing the building itself.
Until that ambiguity is resolved, we must hold in mind that there are multiple possibilities (or hypotheses) for where we are in relation to our destination. In a study of mice, MIT neuroscientists have now discovered that these hypotheses are explicitly represented in the brain by distinct neural activity patterns.
This is the first time that neural activity patterns that encode simultaneous hypotheses have been seen in the brain. The researchers found that these representations, which were observed in the brain’s retrosplenial cortex (RSC), not only encode hypotheses but also could be used by the animals to choose the correct way to go.
2Institute for Lung Health, Cardiopulmonary Institute, Member of German Lung Center, Justus-Liebig University, Giessen, Germany.
3Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
