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SCFFBXW11 Complex Targets Interleukin-17 Receptor A for Ubiquitin–Proteasome-Mediated Degradation

Interleukin-17 (IL-17) is a pro-inflammatory cytokine that participates in innate and adaptive immune responses and plays an important role in host defense, autoimmune diseases, tissue regeneration, metabolic regulation, and tumor progression. Post-translational modifications (PTMs) are crucial for protein function, stability, cellular localization, cellular transduction, and cell death. However, PTMs of IL-17 receptor A (IL-17RA) have not been investigated. Here, we show that human IL-17RA was targeted by F-box and WD repeat domain-containing 11 (FBXW11) for ubiquitination, followed by proteasome-mediated degradation. We used bioinformatics tools and biochemical techniques to determine that FBXW11 ubiquitinated IL-17RA through a lysine 27-linked polyubiquitin chain, targeting IL-17RA for proteasomal degradation.

Nanowires: a new pathway to nanotechnology-based applications

The synthesis and the characterisation of silicon nanowires (SiNWs) have recently attracted great attention due to their potential applications in electronics and photonics. As yet, there are no practical uses of nanowires, except for research purposes, but certain properties and characteristics of nanowires look very promising for the future.

How Nanowires Work

In the next section, we’ll look at the ways scientists can grow nanowires from the bottom up.

Looking at the Nanoscale.

A nanoscientist’s microscope isn’t the same kind that you’ll find in a high school chemistry lab. When you get down to the atomic scale, you’re dealing with sizes that are actually smaller than the wavelength of visible light. Instead, a nanoscientist could use a scanning tunneling microscope or an atomic force microscope. Scanning tunneling microscopes use a weak electric current to probe the scanned material. Atomic force microscopes scan surfaces with an incredibly fine tip. Both microscopes send data to a computer, which assembles the information and projects it graphically onto a monitor.

Neuralink Patient Controls a Robotic Arm Telepathically! (Interview w/ Nick Wray)

Follow Nick on X: https://twitter.com/Telepath_8

Pre-order linkaChart for free: https://linkaChart.ai/?utm_term=ryan2

Generate AI voice audio via ElevenLabs: https://try.elevenlabs.io/xe894d3yv35h.

Neura Pod is a series covering topics related to Neuralink, Inc. Topics such as brain-machine interfaces, brain injuries, and artificial intelligence will be explored. Host Ryan Tanaka synthesizes information, shares the latest updates, and conducts interviews to easily learn about Neuralink and its future.

Sign up for Neuralink’s Patient Registry: https://neuralink.com/trials/

Join the Neuralink team: https://neuralink.com/careers/

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I Don’t Recognize Myself Anymore // Dark Ambient Mix

I am many.

A dark ambient journey through feeling lost, detached, and emotionally numb.
use this mix for late-night thoughts, study, writing, sleep or to to calm down.
→▫️support me on ko-fi: https://ko-fi.com/blackridge.

→ download on bandcamp: https://blackridgeofficial.bandcamp.com/track/i-dont-recognize-myself-anymore.
→ get the wallpapers: https://ko-fi.com/s/a9d71bee15

#darkambient #backrooms #sad #liminalspace #sleep.

All audio has been modified, mixed, and mastered by blackridge.

Continue reading “I Don’t Recognize Myself Anymore // Dark Ambient Mix” | >

For those living with dementia, new study suggests shingles vaccine could slow the disease

An unusual public health policy in Wales may have produced the strongest evidence yet that a vaccine can reduce the risk of dementia. In a new study led by Stanford Medicine, researchers analyzing the health records of Welsh older adults discovered that those who received the shingles vaccine were 20% less likely to develop dementia over the next seven years than those who did not receive the vaccine.

The remarkable findings, published April 2 in Nature, support an emerging theory that viruses that affect the nervous system can increase the risk of dementia. If further confirmed, the new findings suggest that a preventive intervention for dementia is already close at hand.

In a follow-up study published Dec. 2 in Cell, the researchers found that the vaccine may also benefit those already diagnosed with dementia by slowing the progress of the disease.

‘Walking’ water discovery on 2D material could lead to better anti-icing coatings and energy materials

A surprising discovery about how water behaves on one of the world’s thinnest 2D materials could lead to major technological improvements, from better anti-icing coatings for aircraft and self-cleaning solar panels to next-generation lubricants and energy materials.

In a study published in Nature Communications, researchers from the University of Surrey and Graz University of Technology tested two ultra-thin sheet-like materials with a honeycomb structure— graphene and hexagonal boron nitride (h-BN). While graphene is electrically conductive—making it a key contender for future electronics, sensors and batteries—h-BN, often called “white graphite,” is a high-performance ceramic material and electrical insulator.

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