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Widely-prescribed opioid painkiller tramadol not significantly effective for easing chronic pain, analysis finds

The strong opioid painkiller tramadol is not significantly effective at easing the chronic pain for which it’s widely prescribed, finds a pooled data analysis of the available research, published in BMJ Evidence-Based Medicine.

It likely increases the risk of serious side effects, including , the findings indicate, prompting the researchers to conclude that the potential harms of tramadol probably outweigh its benefits, and that its use should be minimized.

Tramadol is a dual-action widely prescribed for the treatment of moderate to severe acute and chronic pain. As such, it’s recommended in several medical guidelines for pain management, note the researchers.

AI-based model can help traffic engineers predict future sites of possible crashes

In a significant step toward improving road safety, Johns Hopkins University researchers have developed an AI-based tool that can identify the risk factors contributing to car crashes across the United States and to accurately predict future incidents.

The tool, called SafeTraffic Copilot, aims to provide experts with both crash analyses and crash predictions to reduce the rising number of fatalities and injuries that happen on U.S. roads each year.

The work, led by Johns Hopkins University researchers, is published in Nature Communications.

Nobel Prize: Quantum Tunneling on a Large Scale

The 2025 Nobel Prize in Physics recognizes the discovery of macroscopic quantum tunneling in electrical circuits.

This story will be updated with a longer explanation of the Nobel-winning work on Thursday, 9 October.

Running up against a barrier, a classical object bounces back, but a quantum particle can come out the other side. So-called quantum tunneling explains a host of phenomena, from electron jumps in semiconductors to radioactive decays in nuclei. But tunneling is not limited to subatomic particles, as underscored by this year’s Nobel Prize in Physics. The prize recipients—John Clarke from the University of California, Berkeley; Michel Devoret from Yale University; and John Martinis from the University of California, Santa Barbara—demonstrated that large objects consisting of billions of particles can also tunnel across barriers [1– 3]. Using a superconducting circuit, the physicists showed that the superconducting electrons, acting as a collective unit, tunneled across an energy barrier between two voltage states. The work thrust open the field of superconducting circuits, which have become one of the promising platforms for future quantum computing devices.

Physicists detect water’s ultraviolet fingerprint in interstellar comet 3I/ATLAS

For millions of years, a fragment of ice and dust drifted between the stars—like a sealed bottle cast into the cosmic ocean. This summer, that bottle finally washed ashore in our solar system and was designated 3I/ATLAS, only the third known interstellar comet. When Auburn University scientists pointed NASA’s Neil Gehrels Swift Observatory toward it, they made a remarkable find: the first detection of hydroxyl (OH) gas from this object, a chemical fingerprint of water.

Swift’s space-based telescope could spot the faint ultraviolet glow that ground observatories can’t see—because, high above Earth’s atmosphere, it captures light that never reaches Earth’s surface.

Detecting water—through its ultraviolet by-product, hydroxyl—is a major breakthrough for understanding how interstellar comets evolve. In solar-system comets, water is the yardstick by which scientists measure their overall activity and track how sunlight drives the release of other gases. It’s the chemical benchmark that anchors every comparison of volatile ices in a ’s nucleus.

New study rules out binary hardening as cause of Dimorphos’s orbital period drop

A new study has challenged a popular explanation for the unexpected 30-second shortening of Dimorphos’s orbital period. The researchers found that the proposed mechanism would actually produce the opposite effect, given the gravitational dynamics of the small moon. The paper has been accepted for publication in Astronomy & Astrophysics and is currently available on the arXiv preprint server.

Scientists unlock new patterns of protein behavior in cell membranes

Cellular membrane proteins play many important roles throughout the body, including transporting substances in and out of the cell, transmitting signals, speeding up reactions and helping neighboring cells stick together. When they malfunction, it can cause serious diseases including cancer, making them attractive drug targets. But understanding how membrane proteins behave and function can be challenging because their position within the cell’s lipid membrane—a tightly-packed double layer of fat-like molecules—makes them difficult to study.

Flash Joule heating lights up lithium extraction from ores

A new one‑step, water‑, acid‑, and alkali‑free method for extracting high‑purity lithium from spodumene ore has the potential to transform critical metal processing and enhance renewable energy supply chains. The study is published in Science Advances.

As the demand for lithium continues to rise, particularly for use in , smartphones and power storage, current extraction methods are struggling to keep pace. Extracting lithium from is a lengthy process, and traditional methods that use heat and chemicals to extract lithium from rock produce significant amounts of harmful waste.

Researchers led by James Tour, the T.T. and W.F. Chao Professor of Chemistry and professor of materials science and nanoengineering at Rice University, have developed a faster and cleaner method using flash Joule heating (FJH). This technique rapidly heats materials to thousands of degrees within milliseconds and works in conjunction with chlorine gas, exposing the rock to intense heat and chlorine gas, they can quickly convert spodumene ore into usable lithium.

Eco-friendly technology removes toxic PFAS from water

Rice University researchers, in collaboration with international partners, have developed the first eco-friendly technology to rapidly capture and destroy toxic “forever chemicals” (PFAS) in water. The findings, recently published in Advanced Materials, mark a major step toward addressing one of the world’s most persistent environmental threats.

The study was led by Youngkun Chung, a postdoctoral fellow under the mentorship of Michael S. Wong, a professor at Rice’s George R. Brown School of Engineering and Computing, and conducted in collaboration with Seoktae Kang, professor at the Korea Advanced Institute of Science and Technology (KAIST), and Keon-Ham Kim, professor at Pukyung National University in South Korea.

PFAS, short for per-and polyfluoroalkyl substances, are synthetic chemicals first manufactured in the 1940s and used in products ranging from Teflon pans to waterproof clothing and food packaging. Their ability to resist heat, grease and water has made them valuable for industry and consumers. But that same resistance means they do not easily degrade, earning them the nickname “forever chemicals.”

How order and disorder direct chemical reactivity

In nature, the behavior of systems—whether large or small—is always governed by a few fundamental principles. For instance, objects fall downward because it minimizes their energy. At the same time, order and disorder are key variables that also shape physical processes. Systems—especially our homes—tend to become increasingly disordered over time. Even at the microscopic level, systems tend to favor increased disorder, a phenomenon known as an increase in so-called entropy.

These two variables—energy and entropy—play an important role in . Processes occur automatically when energy can be reduced or entropy (disorder) increases.

Under standard conditions—such as in a glass of water—water autodissociation is hindered by both factors, making it a highly unlikely event. However, when strong electric fields are applied, the process can be dramatically accelerated.

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