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High-speed imaging tracks live brain cell activity in awake mice

A research team from the School of Engineering at The Hong Kong University of Science and Technology (HKUST) has achieved a breakthrough in brain imaging by developing the world’s first technology to capture high-resolution images of the brains of awake experimental mice in a nearly noninvasive manner.

By eliminating the need for anesthesia, this innovation enables scientists to study in its fully functional state. The advancement promises deeper insights into human brain function in both healthy and diseased conditions, opening new frontiers in neuroscience research.

The study was recently published in Nature Communications in a paper titled “Rapid adaptive optics enabling near-noninvasive high-resolution brain imaging in awake behaving mice.”

Sperm molecules can predict IVF success

The sperm is not a passive supplier of genetic material to the egg. A study from Linköping University, Sweden, shows that certain molecules that come with the sperm, so-called micro-RNA, contribute to the development of the embryo several days after conception. The findings, published in the journal Nature Communications, may in the long term, contribute to better diagnosis and treatment of involuntary childlessness.

“It seems that sperms can help with embryo development by bringing other molecules with them, in addition to DNA. These molecules aid in starting embryo development. So you can say that the sperm, or the male part of conception, has a greater significance than was previously understood,” says Anita Öst, professor of cell and at Linköping University, who led the study.

Many couples are affected by involuntary childlessness, or infertility. About one in six people suffer from infertility. For some, it is possible to become pregnant through what is known as in vitro fertilization, IVF, which takes place outside the body. The fertilized eggs are then transferred to the uterus and hopefully lead to pregnancy. Embryo quality is one of the major limiting factors for successful IVF treatment. Improved early embryo quality assessment could increase chances that IVF treatment leads to pregnancy.

Nobel winner, HPE and chip industry firms team up to make a practical quantum supercomputer

John M. Martinis, one of this year’s winners of the Nobel Prize in physics for breakthroughs in quantum computing, on Monday formed an alliance with HPE and several chip firms to create a practical, mass-producible quantum supercomputer.

A scalpel that can diagnose? Scientists unveil a ‘Lab-on-a-Scalpel’ for real-time surgical insights

Imagine a surgeon in the middle of a complex operation, able to get instant biochemical feedback not from a lab down the hall, but from the very tool in their hand. This vision is now one step closer to reality thanks to researchers at the University of Chemistry and Technology, Prague (UCT Prague).

The team, led by Professor Zdeněk Sofer, has developed and validated a “Lab-on-a-Scalpel” concept, a surgical tool with an integrated diagnostic sensor. They published their findings in the journal Analytical Chemistry.

This innovation addresses a critical challenge in surgery: the time lag between sample collection and lab results. During invasive procedures, a patient’s biochemical profile can change rapidly, but traditional testing methods are too slow to provide the real-time data needed for immediate, informed decisions.

New diode chain could be used to develop highpower terahertz technologies

Electromagnetic waves with frequencies between microwave and infrared light, also known as terahertz radiation, are leveraged by many existing technologies, including various imaging tools and wireless communication systems. Despite their widespread use, generating strong and continuous terahertz signals using existing electronics is known to be challenging.

To reliably generate terahertz signals, engineers often rely on frequency multipliers, electronic circuits that can distort an input signal, to generate an output signal with a desired frequency. Some of these circuits are based on Schottky barrier diodes, devices in which the junction between a metal and semiconductor form a one-way electrical contact.

While some frequency multipliers based on Schottky barrier diodes have achieved promising results, devices based on individual diodes can only handle a limited amount of energy. To increase the energy they can manage, engineers can use several diodes arranged in a chain. However, even this approach can have its limitations, as the distribution of the electromagnetic field between the diodes in a chain often becomes uneven.

Our research partners at UC San Diego have just announced revolutionary findings that challenge conventional understanding of human biology with the publication of their paper titled Neural and Molecular Changes During a Mind-Body Reconceptualization

Meditation, and Open Label Placebo Healing Intervention in the scientific journal Communications Biology.

Neural and Molecular Changes During a Mind-Body Reconceptualization, Meditation, and Open Label Placebo Healing Intervention

The landmark study demonstrates how intensive meditation can trigger the same profound brain activity previously documented only with psychedelic substances – while simultaneously activating measurable biological transformations throughout the entire body.

Congenital heart disease mutation linked to kidney damage

Biomedical engineers at Duke University have shown that a genetic mutation that causes congenital heart disease also contributes to kidney damage and developmental defects. Identifying this early cause of kidney damage could enable clinicians to diagnose and address kidney problems much sooner than current practices allow. The research was published on November 3 in the journal Nature Biomedical Engineering.

Congenital heart disease (CHD) is a common cause of death in childhood and affects 1 out of every 1,000 births. The disease occurs when the heart doesn’t form correctly before birth, causing leaky valves, defective vessels, or holes in the heart. While some cases of CHD can be remedied, children with life-threatening complications often require surgery or even a heart transplant. More than 25% of patients also end up developing problems with other organs, which severely compromise life expectancy.

“Research has shown that children diagnosed with CHD almost always have kidney problems by age 4,” said Samira Musah, the Alfred M. Hunt Faculty Scholar Assistant Professor of Biomedical Engineering and Assistant Professor of Medicine at Duke University, and the senior author of the study. “Given the shared developmental origin of the heart and kidney, I wondered if a genetic mutation tied to CHD also causes the observed in affected patients.”

Protein linked to cancer found to play key role in wound healing

When doctors detect elevated levels of SerpinB3 in a blood test, it can signal that something is seriously wrong, from hard-to-treat cancers to severe inflammatory conditions.

SerpinB3 is a that often reveals when the body’s barrier tissues, like the skin or lungs, are under serious stress from cancer or chronic illness.

But new research from Arizona State University shows that SerpinB3, long recognized as a disease marker, also has a natural role in the body: helping to heal wounds.

Silicon Valley data centers totalling nearly 100MW could ‘sit empty for years’ due to lack of power — huge installations are idle because Santa Clara can’t cope with surging electricity demands

Two major facilities built for AI-era workloads remain unpowered while the city races to expand its electricity supply.

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