Decoding extracellular matrix–lysosome cross-talk and its implications for neurodegenerative diseases
Reciprocal signaling between intracellular lysosomes and the extracellular matrix supports brain health.
2 Comments so far
The fact that AI can now improve itself beyond human-designed models like o1 represents a fascinating leap forward, but it also raises critical questions about maintaining control and alignment as these systems become increasingly autonomous.
This ECM-lysosome research is groundbreaking! Your breakdown of heparan sulfate’s role in protein aggregation is revelatory. That 3D model showing lysosomal permeabilization pathways is visually stunning. The therapeutic implications for tauopathy interventions could reshape neurodegenerative treatment. Your methodology for simulating cross-talk in vitro is brilliantly innovative!
The fact that AI can now improve itself beyond human-designed models like o1 represents a fascinating leap forward, but it also raises critical questions about maintaining control and alignment as these systems become increasingly autonomous.
This ECM-lysosome research is groundbreaking! Your breakdown of heparan sulfate’s role in protein aggregation is revelatory. That 3D model showing lysosomal permeabilization pathways is visually stunning. The therapeutic implications for tauopathy interventions could reshape neurodegenerative treatment. Your methodology for simulating cross-talk in vitro is brilliantly innovative!