Lifeboat Foundation

Northwestern Medicine investigators have identified a previously unknown regulator of tumor immune evasion, which may help improve the efficacy of current and future anti-tumor immunotherapies, according to recent findings published in the Journal of Clinical Investigation.

“The study provides a molecular insight into understanding why some cancer patients cannot be treated by the checkpoint blockade antitumor therapy, but others can,” said Deyu Fang, Ph.D., the Hosmer Allen Johnson Professor of Pathology and senior author of the study.

Antitumor immunotherapy is a type of cancer treatment that helps the immune system in fighting cancer and includes a range of therapy types, such as immune checkpoint inhibitors. Immune checkpoints help prevent the immune system from being too strong and eradicating other cells, including cancer cells.

MIT CSAIL scientists, using new AI models, have been successful at identifying potential high-risk patients of pancreatic cancer.

The forces reshaping labor markets will impact productivity, growth, inflation and deficits, creating a new set of winning and losing industries and countries.

The immune system deteriorates with age, making COVID-19 particularly deadly in older people—but to date, no clinically available medication addresses this key risk factor. A study published today in Nature shows that an oral drug that reverses multiple aspects of immune aging effectively prevents death in a mouse model of COVID-19, suggesting that the medication could be used to protect the elderly patients who are at greatest risk in the pandemic.

In the study, daily doses of BGE-175 (asapiprant) protected aged mice from a lethal dose of SARS-CoV-2, the virus that causes COVID-19. Ninety percent of mice that received the drug survived, whereas all untreated control mice died. BGE-175 treatment was initiated two days after infection, when the mice were already ill, a time-frame relevant to real-life clinical situations in which patients would receive medication only after becoming symptomatic.

The mouse model used in the study closely mirrored the pathological progression of human COVID-19. The mouse-adapted strain of SARS-CoV-2 generated by the researchers caused a disease that shared many of the hallmarks of human COVID-19: accumulation of fluid in the air sacs of the lungs, extensive infiltration of lung tissue by immune cells, and high levels of pro-inflammatory factors called cytokines.

The design uses China’s first diamond semiconductor material.

Time to move philosophers into the lab. AI is making theories of consciousness testable.

Consciousness is one of the most mysterious and fascinating aspects of human existence. It is also one of the most challenging to study scientifically, as it involves subjective experiences that are not directly observable or measurable. David Chalmers, a professor of philosophy and neural science at NYU mentions in his book The Conscious Mind.

“It may be the largest outstanding obstacle in our quest for a scientific understanding of the universe.”

The real questions are: how can we approach the problem of consciousness from a rigorous and objective perspective? Is there a way to quantify and model the phenomena of awareness, feelings, thoughts, and selfhood? There is no definitive answer to this question, but some researchers have attempted to use mathematical tools and methods to study these phenomena. Self-awareness, for instance, is the ability to perceive and understand the things that make you who you are as an individual, such as your personality, actions, values, beliefs, and even thoughts. Some studies have used the mirror test to assess the development of self-awareness in infants and animals.

The enduring mystery of dark matter has led some physicists to propose that it was forged in a distinct moment of cosmic creation, potentially transforming our view of the early universe.

By Stuart Clark

Carbon dioxide electroreduction in acidic environments has been suboptimal. Here, the authors addressed this issue by designing a gas diffusion electrode with a special metal structure, which achieves efficient electroreduction while conducting a systematic investigation of the underlying mechanism.