Lifeboat Foundation

Muscle from a mouse model of Duchenne muscular dystrophy. Fibrous scar tissue is in blue and healthy muscle is in pink. CONBOY LAB AND MURTHY LAB While promising, applications of CRISPR-Cas9 gene editing have so far been limited by the challenges of delivery—namely, how to get all the CRISPR parts to every cell that needs them. In a study published today (October 2) in Nature Biomedical Engineering, researchers have successfully repaired a mutation in the gene for dystrophin in a mouse model of Duchenne muscular dystrophy by injecting a vehicle they call CRISPR-Gold, which contains the Cas9 protein, guide RNA, and donor DNA, all wrapped around a tiny gold ball.

The authors have made “great progress in the gene editing area,” says Tufts University biomedical engineer Qiaobing Xu, who did not participate in the work but penned an accompanying commentary. Because their approach is nonviral, Xu explains, it will minimize the potential off-target effects that result from constant Cas9 activity, which occurs when users deliver the Cas9 template with a viral vector.

Duchenne muscular dystrophy is a degenerative disease of the muscles caused by a lack of the protein dystrophin. In about a third of patients, the gene for dystrophin has small deletions or single base mutations that render it nonfunctional, which makes this gene an excellent candidate for gene editing. Researchers have previously used viral delivery of CRISPR-Cas9 components to delete the mutated exon and achieve clinical improvements in mouse models of the disease.

Continue reading “Nonviral CRISPR Delivery Using Gold Nanoparticles a Success” »

It’s the future of fast food bytes in the Big Apple.

Robots will replace humans and cash won’t be accepted at a soon-to-open Shake Shack in the East Village, reps for the popular burger chain said Monday.

Customers will place orders via an app and at touch-screen kiosks inside the restaurant, which is scheduled to open an Astor Place branch later this month, according to company CEO Randy Garutti.

Continue reading “Robots are replacing fast food workers at new Shake Shack” »

Forget editing embryos. We’re nearly ready to use CRISPR to change DNA inside our own bodies to treat many disorders, from hepatitis B to muscular dystrophy.

Ikea is known for its flat-pack kitchen tables, islands, and cabinets.

Now the home furnishings retailer is experimenting with products that allow people to harvest food at home.

Space10, Ikea’s innovation lab, has designed a prototype of a mini-farm that can grow greens and herbs indoors.

Continue reading “Ikea has debuted an indoor farm that grows greens three times faster than a garden” »

These recent advances in hardware have highlighted a chicken-and-egg problem: what use will quantum machines be if there is no software to run on them? That accounts for this year’s race to win over developers, who will need to learn a completely new programming approach in preparation for the future machines.

Problem is to persuade developers to make programs for machines that don’t yet exist.

On Friday, Tesla and SpaceX CEO Elon Musk said that the company was halfway done building the battery bank that will become the world’s biggest battery once it’s complete. Musk made the announcement at a party overlooking the project’s construction, ABC News Australia reported.

Tesla is building the 129-MWh battery with French energy company Neoen. The battery will be draw energy from Neoen’s Hornsdale wind farm that’s 142 miles north of Adelaide. The electricity will be delivered to South Australians during peak grid times to reduce the number of blackouts in the area, which are frequent in summer months.

“The system is a big battery, a battery big enough to power 50,000 houses — the biggest in the world,” Neoen global COO Romain Desrousseaux previously told Business Insider.

Continue reading “Tesla says it’s halfway done building the world’s biggest battery” »

The importance of telomere length is becoming increasingly clear. BioViva Sciences is leading the way in exploring applications of this knowledge.

To learn more visit https://bioviva-science.com/

Continue reading “The Importance of Telomerase” »

Want to live longer? Here’s one way.

Summary: One in four Americans with type 2 diabetes doesn’t know they have the disease. Walking around with untreated diabetes more than doubles your risk of stroke, heart attack, and early death. Add years to your life by knowing your status, and then managing the condition. Type 2 diabetes can be treated with inexpensive tablets. This article provides a two-minute online assessment, which shows if you are at risk.

Today, one in eight adult Americans has diabetes, according to the latest report from the U.S. Centers for Disease Control and Prevention (CDC). Amazingly, one in four of them doesn’t know they have the disease. Walking around with untreated diabetes more than doubles your risk of severe health complications, including stroke, heart attack, and early death. You can add years to your life by managing type 2 diabetes, a disease which can be treated with inexpensive tablets.

Continue reading “Avoid Diabetes Deadly Effects by Early Action” »

Every 100 years or so, our Sun gives off a great big belch that sends an intense wave of charged particles towards Earth. This wasn’t a problem in the past, but our high-tech civilization is now disturbingly vulnerable to these solar storms. A new study quantifies the economic risks posed by these extreme solar storms, while also proposing a super-futuristic solution to the problem: an Earth-sized shield built in outer space.

The term “solar storm” is used to identify the various nasties the Sun can hurl our way, including x-rays, charged particles, and magnetized plasma. In 1859, a series of powerful coronal mass ejections (CMEs) hit our planet head on, disrupting telegraph stations and causing widespread communication outages. If we were to be hit by an equally powerful solar storm today, it would knock out satellites and electrical grids, disrupting global communications, transportation, and supply chains. Total worldwide losses could reach up to $10 trillion, with recovery taking many years.