Lifeboat Foundation

Long-term data from a study implemented by the # NIH-funded International Maternal Pediatric Adolescent AIDS Clinical Trials Network showed very early antiretroviral therapy (ART) for infants who acquired HIV in utero enabled some infants to sustain viral suppression for more than two years.

Very early ART for in-utero HIV-1 can achieve sustained virological suppression in association with biomarkers indicating restricted HIV-1 reservoirs by age 2 years, which might enable potential ART-free remission.

However, when major genome rearrangements occur — like the ones that the team was seeing in the skate’s DNA — boundaries can be lost, and the relative positions of genes on chromosomes can change. As a result, “some enhancers can provide instructions to the wrong gene,” explained Dario Lupiáñez, an evolutionary biologist at the Max Delbrück Center in Berlin and one of the senior authors of the study.

It seemed possible that the changes in the 3D architecture of the skate genome might have disrupted the ancient blocks of genes the skates inherited from their sharklike ancestors, affecting the genes’ function. “We were trying to look at whether some genome rearrangements in the little skate actually break these blocks,” said Ferdinand Marlétaz, a genomicist at University College London and co-first author of the study.

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Years after Mark Zuckerberg said encrypted chats were coming to Messenger, it’s finally being enabled by default.

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The switch to default has been in the works for a long time.

Continue reading “Messenger is finally getting end-to-end encryption by default” »

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