Lifeboat Foundation

A study from the UNC School of Medicine showed that the protein NLRP12, known for its anti-inflammatory effects, also protects mice on a high-fat diet against obesity and insulin resistance; it might have a similar effect in humans [1].

Study abstract

In addition to high-fat diet (HFD) and inactivity, inflammation and microbiota composition contribute to obesity. Inhibitory immune receptors, such as NLRP12, dampen inflammation and are important for resolving inflammation, but their role in obesity is unknown. We show that obesity in humans correlates with reduced expression of adipose tissue NLRP12. Similarly, Nlrp12/ mice show increased weight gain, adipose deposition, blood glucose, NF-kB/ MAPK activation, and M1-macrophage polarization. Additionally, NLRP12 is required to mitigate HFD-induced inflammasome activation. Co-housing with wild-type animals, antibiotic treatment, or germ-free condition was sufficient to restrain inflammation, obesity, and insulin tolerance in Nlrp12/ mice, implicating the microbiota. HFD-fed Nlrp12/ mice display dysbiosis marked by increased obesity-associated Erysipelotrichaceae, but reduced Lachnospiraceae family and the associated enzymes required for short-chain fatty acid (SCFA) synthesis.

Continue reading “NLRP12 Protein Protects Mice Against Obesity” »

This week, the UN begins a conference to start the long-overdue discussion on updating the 1967 Outer Space Treaty for a cosmos that has gotten a lot more complicated.

[Image: SpaceX]

BATANGAS, Philippines (Reuters) — A Philippine inventor has unveiled what he calls a flying sports car that represents the future of transport, riding it out of a warehouse toward a cheering crowd, leaving a cloud of dust in his wake.

Today, an international group of researchers, including Carnegie Mellon University’s Rachel Mandelbaum, released the deepest wide field map of the three-dimensional distribution of matter in the universe ever made and increased the precision of constraints for dark energy with the Hyper Suprime-Cam survey (HSC).

Biohacking for cures: what you need to know.

Do you know how an ice sheet can move? You’ll find out below.

When designing a robot, key components are the robot’s sensors, which allow it to perceive its environment, and its actuators, the electrical or pneumatic motors that allow the robot to move and interact with its environment.

Consider your hand, which has temperature and pressure sensors, but also muscles as actuators. The omni-skins, as the Science Robotics paper dubs them, combine sensors and actuators, embedding them into an elastic sheet. The robotic skins are moved by pneumatic actuators or memory alloy that can bounce back into shape. If this is then wrapped around a soft, deformable object, moving the skin with the actuators can allow the object to crawl along a surface.

Continue reading “This Robotic Skin Makes Inanimate Objects Move” »

That conclusion is based on a study that reviewed genetic testing results from 1.45 million individuals and found that nearly 25 percent of “variants of uncertain significance” were subsequently reclassified — sometimes as less likely to be associated with cancer, sometimes as more likely.

The study appears in the Journal of the American Medical Association (JAMA).

When variations from the norm are discovered in a gene, the variants are classified as “benign,” “likely benign,” “variant of uncertain significance,” “likely pathogenic,” or “pathogenic.”