Lifeboat Foundation

Scerri now knows when people dropped their tools on the barren ridge, but she can only speculate as to just who they were.

“The hominins responsible for the Acheulean at the site made their way into the heart of now arid Arabia by following lake and river channels. Once there, they climbed up the largest dyke, which was also a source of raw material,” she says. The toolmaking site they created there, perched at a lofty vantage point from which they could observe the surrounding plains, hints at how they may have thought and lived. “We don’t know which hominin taxon made these tools, but what we can say is that the hominins were resourceful and intelligent,” adds Scerri, of the Max Planck Institute and the University of Oxford.

Why these hominins took such a route at all is another area of intriguing speculation. “Although Arabia was wetter when these hominins were at Saffaqah, it was still a marginal environment,” Scerri says. “Were they pushed to the margins by larger brained hominins elsewhere, such as Neanderthals or even Homo sapiens in Africa?”

Continue reading “Stone Tools at Arabian ‘Crossroads’ Present Mysteries of Ancient Human Migration” »

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QUT chemistry researchers have discovered cheaper and more efficient materials for producing hydrogen for the storage of renewable energy that could replace current water-splitting catalysts.

Professor Anthony O’Mullane said the potential for the chemical storage of renewable energy in the form of hydrogen was being investigated around the world.

Continue reading “New catalyst material produces abundant cheap hydrogen” »

This is a critical step along the way to functional quantum computers that can achieve problems far beyond the capacity of traditional systems.

The first big international effort to combat mercury pollution is zeroing in on small gold mines, which account for almost half of annual emissions.

A Phase 2 trial into the efficacy of a male contraceptive gel is about to get underway bringing modern medicine closer than it ever has before to finally developing a male birth control drug, decades after the female contraceptive pill hit the market.

Flying at 50,000 feet, diving deep in the ocean, or hiking for miles with gear through extreme climates, military service members face conditions that place unique burdens on their individual physiology. The potential exists to develop pharmacological interventions to help service members complete their toughest missions more safely and efficiently, and then recover more quickly and without adverse effects, but those interventions must work on complex physiological systems in the human body. They will not be realized under the prevailing system of drug discovery and development with its focus on engaging single molecular targets. DARPA created the Panacea program to pursue the means of rapidly discovering, designing, and validating new, multi-target drugs that work with the body’s complexity to better support the physiological resilience and recovery of military service members.

The premise of Panacea is that the physiological systems of the human body work in complex and highly integrated ways. Drugs exert effects on our bodies by physically interacting with and changing the functional state of biomolecules that govern the functions of cells and tissues. Most drugs target proteins, which are the principle cellular workhorses. Ideally, drugs would target multiple proteins simultaneously to exert precise, network-level effects.

One major problem facing the drug development community is that the functional proteome — the complete collection of proteins and their roles in signaling networks — is largely dark to science. Despite being able to identify many of the proteins within a cell, researchers do not have a firm grasp on everything those proteins do and how they interact to affect physiology.

Rosalinda Roberts had gotten used to seeing weird shapes in the brain. Over three decades of looking at brain tissue under an electron microscope, she’d regularly come across “unknown objects”—specks and blobs in her images that weren’t supposed to be there, and didn’t seem to relate to the synapses and structure that she was studying. “I’d just say, ‘well I’m not going to pay attention to that’” she explains. That’s all changed now.

Finding bacteria in the brain is usually very bad news. The brain is protected from the bacterial menagerie of the body by the blood-brain barrier, and is considered a sterile organ. When its borders are breached, things like encephalitis and meningitis can result. Which made it all the more surprising when Roberts, along with Charlene Farmer and Courtney Walker, realized that the unknown objects in their slides were bacteria.

Many of them were caught mid-stride, entering neurons or penetrating axons. Others were in the process of dividing. They were picky, too, strongly preferring some regions of the brain over others. The surrounding brain tissue showed no signs of inflammation. If the bacteria were in the brain while the individual was alive, they were not pathogenic.

Scientists look around the universe and see amazing structure. There are objects and processes of fantastic complexity. Every action in our universe follows exact laws of nature that are perfectly expressed in a mathematical language. These laws of nature appear fine-tuned to bring about life, and in particular, intelligent life. What exactly are these laws of nature and how do we find them?

The universe is so structured and orderly that we compare it to the most complicated and exact contraptions of the age. In the 18th and 19th centuries, the universe was compared to a perfectly working clock or watch. Philosophers then discussed the Watchmaker. In the 20th and 21st centuries, the most complicated object is a computer. The universe is compared to a perfectly working supercomputer. Researchers ask how this computer got its programming.

How does one explain all this structure? Why do the laws seem so perfect for producing life and why are they expressed in such exact mathematical language? Is the universe really as structured as it seems?

Continue reading “Chaos Makes the Multiverse Unnecessary” »