Lifeboat Foundation

“Everyone is searching for a magic pill that will cure ageing,” explains Richard Siow, who heads up ageing research at King’s College London. “The truth is, lifestyle and diet changes are the most realistic way to extend your life. You can’t just adopt these as you get older. You need to start young – we’re ageing from the moment we’re born.”

Of course, diet and exercise alone won’t enable humans to achieve immortality. We profile the scientists and startups trying to hold back time.

(Rockford, MI & Milton, DE) – Outdoor performance brand Merrell and Dogfish Head Craft Brewery have launched a co-branded trail running shoe inspired by two of their shared passions: the outdoors and beer. The limited-edition Merrell Agility Synthesis X Dogfish trail runner is now available in select retail stores and on Merrell.com, and will also be sold on September 29th at Dogfish Head’s annual Dogfish Dash in Milton, DE.

Available in a “SeaQuench” colorway for men and women, the design of the shoe is inspired by the most thirst-quenching beer Dogfish Head has ever brewed: SeaQuench Ale is now the best-selling sour beer in America, and is recognized by its signature sea-foam green can and off-centered ingredients, including black limes and sea salt, all of which are incorporated into the shoe design.

But didn’t properly treat the new water to prevent corroding water pipes resulting in eroded lead pipes and contaminated water across the city.

Officials denied that the water was unsafe for more than a year…until activism by Flint residents brought national attention and pressure…

Some of the leading theories of quantum gravity prohibit it, while in others, time travel happens all the time.

They could be used to create magnet grabbers or a replica T-1000.

ARLINGTON, Va. — The Army successfully tested its ability to redirect munitions in flight Aug. 28 in an experiment over the Mohave Desert involving an unmanned aircraft, smart sensors and artificial intelligence.

It was the “signature experiment for FY19” said Brig. Gen. Walter T. Rugen, director of the Future Vertical Lift Cross-Functional Team, speaking Thursday at the Association of the U.S. Army’s “Hot Topic” forum on aviation.

The experiment at Naval Air Weapons Station China Lake, California, tested a capability developed by his CFT called A3I, standing for Architecture, Automation, Autonomy and Interfaces.

San Francisco.

Gene-editing technology offers the potential to treat inherited disorders with selective edits and corrections to an afflicted individual’s genetic code. But with such molecular tinkering comes with the risk of unintended changes to the genome.

Biotech startup Trucode Gene Repair is developing technology that it claims can edit genes in a way that reduces the risk of these so-called “off-target effects.” The South San Francisco company is announcing Tuesday that it has raised $34 million to support its research. Trucode disclosed that its investors in the financing include Kleiner Perkins and GV.

Growing evidence supports the antagonistic pleiotropy theory of mammalian aging. Accordingly, changes in gene expression following the pluripotency transition, and subsequent transitions such as the embryonic–fetal transition, while providing tumor suppressive and antiviral survival benefits also result in a loss of regenerative potential leading to age-related fibrosis and degenerative diseases. However, reprogramming somatic cells to pluripotency demonstrates the possibility of restoring telomerase and embryonic regeneration pathways and thus reversing the age-related decline in regenerative capacity. A unified model of aging and loss of regenerative potential is emerging that may ultimately be translated into new therapeutic approaches for establishing induced tissue regeneration and modulation of the embryo-onco phenotype of cancer.

Keywords:

• acetyl-CoA
• aging
• AMPK
• dietary restriction
• DNA methylation
• epigenetics
• mTOR
• pluripotent stem cells
• regeneration

Aging is often defined as a progressive deterioration of an organism over time, wherein the risk of mortality increases exponentially with age in the postreproductive years. Although everyday environmental risks from predation or infectious disease (e.g., stochastic risks) necessarily lead to increased mortality over time, they are not considered core to the definition of the aging process per se [1,2]. Thus, an important criterion of aging is that it encompasses virtually every somatic tissue type, including the gonads (though not necessarily the germ-line cells themselves, given their role in potentially perpetuating the species) [3]. In order to distinguish the aging process from damage that occurs stochastically over time, Benjamin Gompertz described aging as a process leading to an exponential increase in mortality with time, that is, R_m = R₀e^at where ‘R_m’ represents the probability of mortality between ages ‘t’ and ‘t + 1’.

Over the weekend and through today, 12 more Ebola cases were confirmed in the Democratic Republic of the Congo (DRC), lifting the overall outbreak total to 3,081.

In other developments, the DRC, with support from its global health partners, launched new infection prevention and control (IPC) efforts to curb healthcare-acquired infections.