Lifeboat Foundation

Hutchinson–Gilford progeria syndrome (HGPS) is a rare lethal genetic disorder characterized by symptoms reminiscent of accelerated aging. The major underlying genetic cause is a substitution mutation in the gene coding for lamin A, causing the production of a toxic isoform called progerin. Here we show that reduction of lamin A/progerin by a single-dose systemic administration of adeno-associated virus-delivered CRISPR–Cas9 components suppresses HGPS in a mouse model.

You can feed your porgs and play fetch with a Chewbacca doll.

It won’t be a separate branch.

Not exactly the ‘separate but equal’ branch that was originally planned.

It’s inevitable in life, but aging isn’t really something people look forward to. Researchers have been seeking ways to reduce the impact of aging, not only because of vanity but also because as we age, there is a greater risk of certain serious health conditions like cancer, heart disease and neurodegenerative conditions like Alzheimer’s disease. Salk Institute scientists have now used CRISPR/Cas9, the gene-editing tool, to slow down aging. The work, reported in Nature Medicine, showed accelerated aging can be slowed in mice modeling a rare genetic disorder called Hutchinson-Gilford progeria syndrome.

“Aging is a complex process in which cells start to lose their functionality, so it is critical for us to find effective ways to study the molecular drivers of aging,” said the senior author of the report Juan Carlos Izpisua Belmonte, a professor in Salk’s Gene Expression Laboratory. “Progeria is an ideal aging model because it allows us to devise an intervention, refine it and test it again quickly.”

Continue reading “Slowing the Aging Process” »

“We were able to show that there is only a single type of microglia in the brain that exist in multiple flavours,” says project head Prof. Dr. Marco Prinz, medical director of the Institute of Neuropathology at the Medical Center — University of Freiburg. “These immune cells are very versatile all-rounders, not specialists, as has been the textbook opinion up to now,” sums up Prof. Prinz.

A team of researchers under the direction of the Medical Center — University of Freiburg has created an entirely new map of the brain’s own immune system in humans and mice. The scientists succeeded in demonstrating for the first time ever that the phagocytes in the brain, the so-called microglia, all have the same core signature but adopt in different ways depending on their function. It was previously assumed that these are different types of microglia. The discovery, made by means of a new, high-resolution method for analyzing single cells, is important for the understanding of brain diseases. Furthermore, the researchers from Freiburg, Göttingen, Berlin, Bochum, Essen, and Ghent (Belgium) demonstrated in detail how the human immune system in the brain changes in the course of multiple sclerosis (MS), which is significant for future therapeutic approaches. The study was published on 14. February 2019 in the journal Nature.

Caveat: it’s only flavors are “bitter” and “salty”.

Cranio. 2000 Apr;18:135–41.

Olson GB, Savage S, Olson J.

Eight-year-old George Madden is wandering the “Moving Beyond Earth” gallery of the Smithsonian’s National Air and Space Museum on a blustery day in February. Clad in an orange spacesuit, he is examining the artifacts—the main engine from the Space Shuttle, flight suits, a rotating chair from a 1992 Spacelab mission—and lingering near a display about space travel. He gazes up at words printed in large white text on the wall: “When I grow up, I want to be an astronaut.”

His father, 52-year-old Michael Madden, will soon make history as one of the first 1,000 people to travel to space. Madden is a paid customer of Virgin Galactic, one of six “future astronauts” in the crowd who will be among the first wave of passengers to be carried into space by SpaceShipTwo when the company begins its commercial flights, maybe as soon as before the end of the year. Madden and his son, along with other space aficionados, are in the museum for a donation ceremony. Sir Richard Branson, founder of the Virgin Group, and Enrico Palermo, president of the Spaceship Company, are turning over the hybrid engine that powered Virgin Galactic’s SpaceShipTwo, VSS Unity, on its first space flight on December 13, 2018.

Continue reading “The Engine Powering the Future of Civilian Spaceflight Enters the Collections” »

The insides of neutron stars—the densest form of matter in the universe—have long been a mystery, but it is one that scientists are starting to crack.

• By Clara Moskowitz