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Oct 25, 2018

Mind’s quality control center found in long-ignored brain area

Posted by in categories: biotech/medical, neuroscience

The cerebellum can’t get no respect. Located inconveniently on the underside of the brain and initially thought to be limited to controlling movement, the cerebellum has long been treated like an afterthought by researchers studying higher brain functions.

But researchers at Washington University School of Medicine in St. Louis say overlooking the cerebellum is a mistake. Their findings, published Oct. 25 in Neuron, suggest that the cerebellum has a hand in every aspect of higher brain functions — not just movement, but attention, thinking, planning and decision-making.

“The biggest surprise to me was the discovery that 80 percent of the cerebellum is devoted to the smart stuff,” said senior author Nico Dosenbach, MD, PhD, an assistant professor of neurology, of occupational therapy and of pediatrics. “Everyone thought the cerebellum was about movement. If your cerebellum is damaged, you can’t move smoothly ­— your hand jerks around when you try to reach for something. Our research strongly suggests that just as the cerebellum serves as a quality check on movement, it also checks your thoughts as well — smoothing them out, correcting them, perfecting things.”

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Oct 25, 2018

How A CPU Works (Hardware + Software Parallelism)

Posted by in category: computing

This video is the third in a multi-part series discussing computing. In this video, we’ll be discussing classical computing, more specifically – how the CPU operates and CPU parallelism.

[0:27–4:57] Starting off we’ll look at, how the CPU operates, more specifically — the basic design of a CPU, how it communicates with memory, the stages it executes instructions in as well as pipelining and superscalar design.

[4:57–8:00] Following that we’ll discuss, computing parallelism, elaborating on the hardware parallelism previously discussed as well as discussing software parallelism through the use of multithreading.

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Oct 25, 2018

Treating Multiple Aging Pathways Simultaneously Extends Healthy Lifespan Of Nematodes

Posted by in categories: biotech/medical, life extension

Drugs that target multiple aging pathways at once significantly extend the healthspan and lifespan of nematodes.

In a paper published in Developmental Cell, scientists from Yale University have demonstrated how targeting multiple pathways related to aging with different drug combinations can slow aging down and extend healthy lifespan in C. elegans [1].


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Oct 25, 2018

Dr. David Sinclair AMA

Posted by in categories: biotech/medical, genetics, life extension

On the 23rd of this month, Dr. David Sinclair did an Ask Me Anything over at the Futurology subreddit in support of the NAD+ Mouse Project on There were a range of interesting questions from the community about his work in aging research, particularly the role of NAD+ in aging.

Dr. David A. Sinclair is a Professor in the Department of Genetics at Harvard Medical School and a co-joint Professor in the Department of Physiology and Pharmacology at the University of New South Wales. He is the co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging and a Senior Scholar of the Ellison Medical Foundation. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente; there, he co-discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability.

More recently, he has been in the spotlight for his work with NAD+ precursors and their role in aging and has been helping to develop therapies that replace NAD+, which is lost with aging, in order to delay the diseases of old age. Below are a selection of questions and answers from the AMA, and we urge you to head over to Reddit Futurology to check out the other questions that people asked.

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Oct 25, 2018

Elon Musk’s superfast LA underground ‘loop’ is coming sooner than you think

Posted by in categories: cybercrime/malcode, Elon Musk

The Boring Company is almost ready to show off its first tunnel under LA, designed to be the ultimate hack for commuters.


  • Eric Mack

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Oct 25, 2018

What Will Happen After The Technological Singularity Ray Kurzweil

Posted by in categories: Ray Kurzweil, singularity

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Oct 25, 2018

The Science of Inequality

Posted by in categories: economics, health, science

How high economic inequality negatively impacts nearly every aspect of human well-being—as well as the health of the biosphere.

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Oct 25, 2018

The 2019 Undoing Aging Conference will again include poster sessions

Posted by in category: life extension

In addition, a small number of posters will be selected for oral presentation.

Poster topics should lie within the scope of the conference: Research contributing to the eventual postponement of age-related decline in health, with an emphasis on measures that repair damage rather than slowing its creation. Poster submissions are due on January 31, 2019.

To submit your poster go to:

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Oct 25, 2018

Finally, the drug that keeps you young

Posted by in categories: biotech/medical, life extension

The brilliant Prof Judith Campisi from Buck Institute on Aging on senescence, senolytics, healthspan and more, a new interview.

Anti-aging pioneer Judith Campisi explains how a recent breakthrough could ward off age-related disease.

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Oct 24, 2018

Reimagining Education in the Exponential Age

Posted by in categories: education, Ray Kurzweil, space

The future of humanity will be radically different than what we see today. As Ray Kurzweil put it, “We won’t experience 100 years of progress in the 21st century—it will be more like 20,000 years of progress (at today’s rate).” We’ll have the potential to live on Mars, connect our minds to machines, and access an abundance of resources.

But is our youth prepared to live in such a world? Are we equipping them with the skills and values necessary to be adaptable, innovative, and purpose-driven in such a world?

Our traditional, industrial-era educational models are simply outdated. What is required is not an incremental change in education, but rather an entire overhaul of the current system. It will take creative imagination to develop new models for 21st-century education.

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