Lifeboat Foundation

Large-scale protein and gene profiling have massively expanded the landscape of cancer-associated proteins and gene mutations, but it has been difficult to discern whether they play an active role in the disease or are innocent bystanders.

In a study published in Nature Cancer, researchers at Baylor College of Medicine revealed a powerful and unbiased machine learning-based approach called FunMap for assessing the role of cancer-associated mutations and understudied proteins, with broad implications for advancing cancer biology and informing therapeutic strategies.

“Gaining functional information on the genes and proteins associated with cancer is an important step toward better understanding the disease and identifying potential therapeutic targets,” said corresponding author Dr. Bing Zhang, professor of molecular and human genetics and part of the Lester and Sue Smith Breast Center at Baylor.

The newly found ORC, designated ORC J0219–0505, was discovered in data from the MIGHTEE survey conducted by the MeerKAT radio telescope located in the Meerkat National Park in the Northern Cape of South Africa. The 371,600 light-year-wide ORC seems to be associated with the elliptical galaxy WISEA J021912.43–050501.8. It has features that seem to set it apart from other ORCs, including the fact that it appears fainter and that details of its structure reveal it leans to one side.

“Odd Radio Circles: Circles of radio emission found around distant galaxies that we still don’t understand,” lead researcher and Western Sydney University astronomer Ray Norris told Space.com. “It’s a completely unexpected discovery, not predicted by the physics we already know, and therefore revealing a gap in our knowledge.

So we hope these will tell us something new about how galaxies form and interact.

Cells in the immune system don’t always fight; they often rest and wait for threats, like viruses or bacteria. When such threats emerge, the cells activate to defend the body. This delicate balance between rest and activation is crucial to our health—immune cells must be poised for activation to protect against threats, but if they’re overly active, autoimmune diseases can result.

But what controls this important balance?

In a new study published in Nature, scientists from Gladstone Institutes and UC San Francisco (UCSF) focused on T cells—which serve a vital role in the immune system—and pinpointed how a network of different proteins controls rest and activation.

The arrival of Paxlovid in December 2021 marked another turning point in the COVID-19 pandemic—an effective antiviral that has since successfully treated millions. But like many antivirals before it, scientists know that at some point, Paxlovid is likely to lose some efficacy due to drug resistance. Researchers working to stay ahead of such emerging threats have now identified a wholly new way to treat SARS-CoV-2 infections—work that may have even broader implications.

In fact, a new study by the Tuschl laboratory introduces a proof-of-concept for a novel class of antivirals that would target a type of enzyme essential not just to SARS, but also many RNA viruses, including Ebola and dengue, as well as cytosolic-replicating DNA viruses, including Pox viruses. The findings may pave the way for a faster and more robust response to future pandemics.

“Nobody has found a way to inhibit this enzyme before,” says Thomas Tuschl, the F. M. Al Akl and Margaret Al Akl professor at Rockefeller. “Our work establishes cap methyl transferase enzymes as therapeutic targets and opens the door to many more antiviral developments against pathogens that until now we’ve had only limited tools to fight.”

The results of a clinical trial into a new malaria vaccine candidate (RH5.1/Matrix-MTM) show it is well-tolerated and offers effective protection against the blood-stage of the disease—the first inoculation to do so.

Malaria, caused by Plasmodium falciparum parasites, is a leading cause of death in children under five in many parts of Africa. Blood-stage malaria —when the parasite infects red blood cells —causes symptoms of the disease like fever and chills, and can lead to severe, life-threatening complications such as anemia and organ failure.

The study has been run by scientists at the University of Oxford in collaboration with the Clinical Research Unit of Nanoro (CRUN) at the Institut de Recherche en Sciences de la Santé (IRSS) in Burkina Faso, the London School of Hygiene and Tropical Medicine (LSHTM) in the U.K. and the National Institute of Health (NIH) in the U.S., with support from other partners including the Serum Institute of India Pvt. Ltd, Novavax and ExpreS2ion Biotechnologies ApS.

Researchers at the University of Copenhagen have demonstrated that the brain’s ability to learn certain skills can be significantly enhanced if both the brain and nervous system are primed by carefully-calibrated, precisely-timed electrical and magnetic stimulations. This new research has the potential to open entirely new perspectives in rehabilitation and possibly elite sports.

Scientists meticulously calculate the process. First, electricity is delivered to a nerve in the forearm of a test subject. Milliseconds later, magnetic stimulation is applied to the motor area of their brain using a coil placed on their head. The immediate effect is visible as small, involuntary twitches in the subject’s hand. Ten seconds later, the process is repeated.

While this may evoke images of Dr. Frankenstein at work, the reality is that of pioneering research into the brain’s capacity to learn that could unlock new understandings of brain function and provide new avenues for motor training and rehabilitation. The young, healthy test subjects reportedly felt almost nothing during the process, but displayed enhanced benefits from their motor training session thereafter.

Human fingerprints are detailed, unique, difficult to alter, and durable over the life of an individual, making them suitable as long-term markers of human identity. Could the same concept be used to help identify cancer? A new study by researchers at the Centre for Genomic Regulation (CRG) in Barcelona reveals different types of cancer have unique molecular “fingerprints” that are detectable in the early stages of the disease and can be picked up with near-perfect accuracy by small, portable scanners in a few hours. The discovery lays the groundwork for creating new, noninvasive diagnostic tests that detect different types of cancer faster and earlier than currently possible.

The findings are published in the journal Molecular Cell in an article entitled “Epitranscriptomic rRNA fingerprinting reveals tissue-of-origin and tumor-specific signatures.”

“Our ribosomes are not all the same. They are specialized in different tissues and carry unique signatures that reflect what’s happening inside our bodies,” explained ICREA research professor Eva Novoa, PhD, lead author of the study and researcher at the CRG. “These subtle differences can tell us a lot about health and disease.”

PillBot’s thrusters and high-res cameras make remote stomach diagnostics a reality—revolutionizing gastroenterology.

Endiatx’s swallowable camera uses pumpjet thrusters for remote stomach exams, replacing invasive procedures and advancing telemedicine.

Continue reading “Pillbot: Swallowable robot with thrusters performs endoscopy at home” »

Anyone who has operated a 3D printer before, especially those new to using these specialized tools, has likely had problems with the print bed. The bed might not always be the correct temperature leading to problems with adhesion of the print, it could be uncalibrated or dirty or cause any number of other issues that ultimately lead to a failed print. Most of us work these problems out through trial and error and eventually get settled in, but this novel 3D printer instead removes the bed itself and prints on whatever surface happens to be nearby.

The printer is the product of [Daniel Campos Zamora] at the University of Washington and is called MobiPrint. It uses a fairly standard, commercially available 3D printer head but attaches it to the base of a modified robotic vacuum cleaner. The vacuum cleaner is modified with open-source software that allows it to map its environment without the need for the manufacturer’s cloud services, which in turn lets the 3D printer print on whichever surface the robot finds in its travels. The goal isn’t necessarily to eliminate printer bed problems; a robot with this capability could have many more applications in the realm of accessibility or even, in the future, printing while on the move.

Continue reading “3D Printer Eliminates The Printer Bed” »