Lifeboat Foundation

Inside a cell, tentacled vesicles shuttle cargo for sorting. DNA rearranges in the nucleus as stem cells differentiate into neurons. Neighboring neurons cling to one another through a web-like interface. And a new microscopy technique shows it all, in exquisite detail.

The technique, called cryo-SR/EM, melds images captured from electron microscopes and super-resolution light microscopes, resulting in brilliant, clear detailed views of the inside of cells—in 3D.

For years, scientists have probed the microscopic world inside cells, developing new tools to view these basic units of life. But each tool comes with a tradeoff. Light microscopy makes it simple to identify specific cellular structures by tagging them with easy-to-see fluorescent molecules. With the development of super-resolution (SR) fluorescence microscopy, these structures can be viewed with even greater clarity. But fluorescence can reveal only a few of the more than 10,000 proteins in a cell at a given time, making it difficult to understand how these few relate to everything else. Electron microscopy (EM), on the other hand, reveals all cellular structures in high-resolution pictures—but delineating one feature from all others by EM alone can be difficult because the space inside of cells is so crowded.

CAPE CANAVERAL, Fla. (WTHR) — SpaceX plans to intentionally blow up a rocket on Saturday morning.

The test is being conducted in advance of a piloted flight.

The test, which is scheduled for Saturday morning, will demonstrate the spacecraft’s capabilities to safely separate from the rocket in the event of an in-flight emergency.

A team of researchers from the University of New England, the Australian Age of Dinosaurs Natural History Museum and Swinburne University of Technology, all in Australia, has identified fossils found near Winton as remains of the largest theropod found to date in Australia. In their paper published in the journal Royal Society Open Science, the group describes the bones they found and its likely species.

In 2017, a farmer in the central-western Queensland town of Winton discovered several fragmented bones on his property. Suspecting they might be dinosaur fossils, he contacted the Australian Age of Dinosaurs Natural History Museum. A team was assembled, and a dig was established. The researchers found 15 more limb and vertebrae fossils.

The fossils closely resembled Australovenator wintonesis—a theropod species that was discovered in Australia in 2006. Theropods are a group of large, bipedal, carnivorous dinosaurs—included in the group are both Tyrannosaurus rex and Velociraptor. The newly found fossils are bigger than those of the specimen found in 2006, making it difficult to determine if the two specimens are the same species. The fossil size suggests the creature was approximately two meters tall and five to seven meters long. The researchers are not ruling out the possibility that the fossils belong to an undiscovered species. But the larger size indicates that the find represents the largest known carnivore to have lived in Australia.

Elon Musk’s Boring Company has made plenty of progress with its Las Vegas Convention Center people mover. The underground tunnel is now about 50% complete and around six football fields in length, according to the Las Vegas Convention and Visitors Authority.

The Boring Company officially started tunneling for the people mover after a ceremonial groundbreaking event on November 15. In just two months, the project is nearly halfway completed.

The company’s Tunnel Boring Machine (TBM) has been 40 feet underground for months and is working to drill two, one-mile-long tunnels. Boring Company began shipping portions of the TBM to the site in Las Vegas in September. Since then, the project has really started to take shape.

We’re still a long way from Star Trek-style tricorders that can instantly diagnose disease, but medical startup Nanox is hoping to bring a little of the 24th century to a hospital near you. The company has unveiled a new low-cost X-ray scanner called the Nanox. Arc. It hopes to deploy 15,000 units in the coming years, with the aim of making medical scans more available and affordable.

Nanox was founded in 2016 by Japanese venture capitalist Hitoshi Masuya in partnership with Sony. The consumer electronics giant later bowed out, but Masuya joined forces with current CEO Ran Poliakine to split the company’s operations between Israel and Japan. Nanox has now raised a total of $55 million to fund the development of Nanox. Arc, which supposedly offers the same capabilities of traditional X-ray machines with a much smaller footprint and lower operating costs.

Current X-ray machinery is bulky, requiring arrays of rotating tubes with superheated filaments that produce electron clouds. When moved near a metal anode, the filament produces the X-rays needed for imaging. These giant analog contraptions require heavy shielding to keep patients safe, and they use a lot of power. There’s also a substantial upfront cost that can run $2–3 million. The Nanox. Arc, on the other hand, uses silicon micro-electromechanical systems (MEMs) in the form of more than 100 million molybdenum nano-cones that generate electrons.

Researchers at the Buck Institute have extensively profiled the various inflammatory signals given off by senescent human cells and have generated a curated database available for use in the field.

Senescent cells, which stop dividing under stress, are long- recognized drivers of multiple diseases of aging. Mouse studies have shown that targeted removal of these cells and the inflammatory factors they secrete, known as the senescence-associated secretory phenotype (SASP), has beneficial results on multiple organ systems and functions. Success in the laboratory has given rise to companies and research projects aimed at developing either senolytics, drugs that clear senescent cells, or senomorphics, drugs that suppress the SASP. But drug development and clinical utilization require simple, reliable biomarkers to assess the abundance of senescent cells in human tissues. Publishing in PLOS Biology, researchers at the Buck Institute have extensively profiled the SASP of human cells and have generated a curated database available for use in the field.

“The stage is now set for the development of clinically-relevant biomarkers of aging,” said Judith Campisi, Ph.D., Buck professor and one of the senior authors on the paper. “This will speed efforts to get safe and effective drugs into the clinic and, in the long term, could enable physicians to give patients a clear read-out of how well, or poorly, their various tissues and organs are aging.”

Continue reading “Stage is set to develop clinically relevant, senescence-based biomarkers of aging” »

The Black Vault has more than 2,000,000 pages of declassified U.S. Government documents ready to download on nearly any government secret you can imagine. Utilizing the Freedom of Information Act (FOIA), The Black Vault’s founder John Greenewald, Jr. has filed more than 8,000 FOIA requests to amass it all.

Players applaud, say words like Whoo, bang plastic knives on the table and enjoy the best weekends with artificial intelligence as the main act, thanks to AI unleashed in games.

WIRED UK’s science editor, Matt Reynolds, looked at DeepMind’s impact on AI milestones: “It has outplayed Go champions, bested professional StarCraft players and turned its attention to chess and shogi.”

Let the games continue but the serious stuff must seriously shine. In brief, we can admire that unleashing AI for the purpose of scientific discovery has become especially alive and well thanks to research at DeepMind.

A startup focused on “invisible computing” Thursday unveiled a smart contact lens which delivers an augmented reality display in a user’s field of vision.

The Mojo Vision contact lens offers a display with information and notifications, and allows the user to interact by focusing on certain points.

The rigid contact lens, which the company has been developing in stealth mode for some 10 years, may also be used to help people with visual impairments by using enhanced image overlays, and has obtained US approval for testing it as a medical device.