Lifeboat Foundation

More than three decades ago, scientists discovered that a chemical found in a synthetic opioid, MPTP, induced the onset of a form of Parkinson’s disease. In a new study led by scientists from the School of Veterinary Medicine, researchers found that an enzyme in the body can metabolize compounds formed in the brain from alkaloids present in certain foods and tobacco into MPTP-like chemicals, triggering a neurodegenerative condition in mice.

The researchers, led by Narayan Avadhani and Mrittika Chattopadhyay, suggest that the enzyme, mitochondrial CYP2D6, presents a potentially powerful new target for Parkinson’s treatment.

“Over the past two or three decades, researchers have tried inhibiting the process by which they believed MPTP was metabolized, with mixed success,” says Avadhani. “We believe that mitochondrial CYP2D6 is the more direct drug target, which might prove better in treating idiopathic Parkinson’s disease.”

Scientists at Lancaster University have announced that they have invented an electronic memory device that realises the dream of universal memory – a previously hypothetical technology long considered to be revolutionary for the industry.

Universal memory is a computer data storage technology that until now has been purely conceptual, combining the speed and low cost of dynamic random-access memory (DRAM) and the stability of flash memory. This also would result in significantly lower power consumption.

It had been considered impossible by some in the field, but scientists at Lancaster University say that the electronic memory device they have invented and patented is the realisation of the universal memory dream.

Gravity has no quantum properties and it drives physicists crazy.

By adulthood, the heart is no longer able to replenish injured or diseased cells. As a result, heart disease or an event like a heart attack can be disastrous, leading to massive cell death and permanent declines in function. A new study by scientists at the Lewis Katz School of Medicine at Temple University (LKSOM), however, shows that it may be possible to reverse this damage and restore heart function, even after a severe heart attack.

The study, published June 21 in the print edition of the journal Circulation Research, is the first to show that a very small RNA molecule known as miR-294, when introduced into heart cells, can reactivate heart cell proliferation and improve heart function in mice that have suffered the equivalent of a heart attack in humans.

“In previous work, we discovered that miR-294 actively regulates the cell cycle in the developing heart,” said Mohsin Khan, Ph.D., Assistant Professor of Physiology at the Center for Metabolic Disease Research at LKSOM. “But shortly after birth miR-294 is no longer expressed.”

The diabetes drug metformin, sometimes taken to slow aging, may blunt the health benefits of exercise.

Crypto news: Facebook” s Libra, a new cryptocurrency is announced as a peer-to-peer payment within messenger apps. Cross-border transactions near zero fees is a major step towards the Global Brain.

“Mirror, mirror on the wall, who’s the smartest species of them all?”

“You, oh Homo Sapiens, are smart, it is true. But AI will be smarter even than you.”

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Continue reading “Technology is a Magnifying Mirror, Not a Crystal Ball” »

In a new survey of the sub-seafloor off the U.S. Northeast coast, scientists have made a surprising discovery: a gigantic aquifer of relatively fresh water trapped in porous sediments lying below the salty ocean. It appears to be the largest such formation yet found in the world. The aquifer stretches from the shore at least from Massachusetts to New Jersey, extending more or less continuously out about 50 miles to the edge of the continental shelf. If found on the surface, it would create a lake covering some 15,000 square miles. The study suggests that such aquifers probably lie off many other coasts worldwide, and could provide desperately needed water for arid areas that are now in danger of running out.

The researchers employed innovative measurements of electromagnetic waves to map the water, which remained invisible to other technologies. “We knew there was fresh water down there in isolated places, but we did not know the extent or geometry,” said lead author Chloe Gustafson, a Ph.D. candidate at Columbia University’s Lamont-Doherty Earth Observatory. “It could turn out to be an important resource in other parts of the world.” The study appears this week in the journal Scientific Reports.

The first hints of the aquifer came in the 1970s, when companies drilled off the coastline for oil, but sometimes instead hit fresh water. Drill holes are just pinpricks in the seafloor, and scientists debated whether the water deposits were just isolated pockets or something bigger. Starting about 20 years ago, study coauthor Kerry Key, now a Lamont-Doherty geophysicist, helped oil companies develop techniques to use electromagnetic imaging of the sub-seafloor to look for oil. More recently, Key decided to see if some form of the technology could also be used also to find fresh-water deposits. In 2015, he and Rob L. Evans of Woods Hole Oceanographic Institution spent 10 days on the Lamont-Doherty research vessel Marcus G. Langseth making measurements off southern New Jersey and the Massachusetts island of Martha’s Vineyard, where scattered drill holes had hit fresh-water-rich sediments.

Air travel accounts for 2%-3% of global greenhouse gas emissions. Are electric engines an answer?