Lifeboat Foundation

Though many negative repercussions of human immunodeficiency virus infection can be mitigated with the use of antiretroviral therapy (ART), one area where medical advances haven’t made as much progress is in the reduction of cognitive impacts. Half of HIV patients have HIV-associated neurocognitive disorders (HAND), which can manifest in a variety of ways, from forgetfulness and confusion to behavior changes and motor deficiencies.

To better understand the mechanisms underlying HAND, researchers from Penn’s School of Dental Medicine and Perelman School of Medicine and from the Children’s Hospital of Philadelphia (CHOP) brought together their complementary expertise to create a laboratory model system using three of the types of brain cells thought to be involved. Led by doctoral student Sean Ryan, who was co-mentored by Kelly Jordan-Sciutto of Penn Dental Medicine and Stewart Anderson of CHOP and Penn Medicine, the model recapitulates important features of how HIV infection and ART affect the brain.

“Frankly the models we generally use in the HIV field have a lot of weaknesses,” says Jordan-Sciutto, co-corresponding author on the paper, which appears in the journal Stem Cell Reports. “The power of this system is it allows us to look at the interaction between different cell types of human origin in a way that is more relevant to patients than other models.”

Artificial intelligence has already played a vital role in the outbreak since day 1—a reminder for the first time in a while that it can be a tool for good.

The Cuda is credited by some with being the first pony car. However, while the Mustang survives to this day, the Barracuda is dead… along with the whole Plymouth brand.

23 photos.

Android smartphone. Announced Feb 2020. Features 6.9″ Dynamic AMOLED 2X display, Exynos 990 chipset, 5000 mAh battery, 512 GB storage, 16 GB RAM, Corning Gorilla Glass 6.

Search and rescue efforts continue as sunlight shows the extensive damage left after Jonesboro, Arkansas, took a direct hit from a tornado on Saturday, causing major damage.

Didymos, a 2,650-foot-wide asteroid, has an atypical cosmic companion— a 535 foot-wide satellite named Didymoon (10). These new two celestial bodies are not making a dangerous rendezvous with Earth, but they do provide an interesting opportunity for an apocalyptic dress rehearsal. NASA and ESA’s Double Asteroid Redirection Test (DART) will head to Didymos, to knock Didymoon off course. Along with its six picture-snapping Italian Space Agency cubesats, the mission will also send a follow-up ESA spacecraft named Hera to definitively answer if we can manipulate the trajectory of Earth-bound asteroids.

Mar 17 2020

Social distancing is here to stay for much more than a few weeks. It will upend our way of life, in some ways forever.

Alumni and supporters look to MIT in time of crisis.

Clinical and design considerations will be published online; goal is to support rapid scale-up of device production to alleviate hospital shortages.