Lifeboat Foundation

Theoretical physicists from SISSA and the University of California at Davis have developed a new approach to heat transport in materials, which finally allows crystals, polycrystalline solids, alloys and glasses to be treated on the same solid footing. It opens the way to the numerical simulation of the thermal properties of a vast class of materials in important fields such as energy saving, conversion, scavenging, storage, heat dissipation, shielding and the planetary sciences, which have thus far dodged a proper computational treatment. The research has been published in Nature Communications.

Heat dissipates over time. In a sense, heat flow is the defining feature of the arrow of time. In spite of the foundational importance of heat transport, the father of its modern theory, Sir Rudolph Peierls, wrote in 1961, “It seems there is no problem in modern physics for which there are on record as many false starts, and as many theories which overlook some essential feature, as in the problem of the thermal conductivity of nonconducting crystals.”

A half-century has passed since, and heat transport is still one of the most elusive chapters of theoretical materials science. As a matter of fact, no unified approach has been able to treat crystals and (partially) disordered solids on equal footing, thus hindering the efforts of generations of materials scientists to simulate certain materials, or different states of the same material occurring in the same physical system or device with the same accuracy.

Chemotherapy works off of a basic premise: kill all rapidly-growing cells in an effort to wipe out tumor cells. The tactic, while generally effective, has quite a few off-target casualties, including cells that produce hair and cells that line the stomach.

Scientists have tried to skirt the problem by creating missile-like drugs that zero in on cancer cells specifically, sparing healthy cells.

These missile-like drugs, known as antibody-drug conjugates (ADCs), have been in the works for decades, but only in recent years have they made it to clinical trials, Kimberly Tsui, a genetics graduate student, told me.

NASA’s Hubble Telescope snapped an incredible photo of a dying star that had astronomers confused.

The NASA picture seems to be showing a bright nucleus surrounded by two stellar bodies that are known as NGC 2371 and NGC 2372.

Industry declares that it will not make DNA changes affecting future generations.

The Internal Revenue Service (IRS) is warning taxpayers about a snowballing email attack that uses messages pretending to be legitimate IRS communications. The end game for the effort is malware being installed on unsuspecting users’ machines; imposters may gain control of the taxpayer’s computer or secretly download software that tracks every keystroke, eventually giving them passwords to sensitive accounts, such as financial accounts.

The gambit starts with messages to taxpayers from email addresses that spoof legitimate IRS addresses. The emails contain a link to a spoofed IRS.gov website that displays fake details about the targeted recipient’s tax refund, return or account.

The fake emails have subject lines like “Automatic Income Tax Reminder” or “Electronic Tax Return Reminder.” They claim to contain a “temporary password” or “one-time password” to access the files purportedly needed to submit a request for a refund or for information. However, those files are actually just malware in disguise.

We learn from our personal interaction with the world, and our memories of those experiences help guide our behaviors. Experience and memory are inexorably linked, or at least they seemed to be before a recent report on the formation of completely artificial memories. Using laboratory animals, investigators reverse engineered a specific natural memory by mapped the brain circuits underlying its formation. They then “trained” another animal by stimulating brain cells in the pattern of the natural memory. Doing so created an artificial memory that was retained and recalled in a manner indistinguishable from a natural one.

Memories are essential to the sense of identity that emerges from the narrative of personal experience. This study is remarkable because it demonstrates that by manipulating specific circuits in the brain, memories can be separated from that narrative and formed in the complete absence of real experience. The work shows that brain circuits that normally respond to specific experiences can be artificially stimulated and linked together in an artificial memory. That memory can be elicited by the appropriate sensory cues in the real environment. The research provides some fundamental understanding of how memories are formed in the brain and is part of a burgeoning science of memory manipulation that includes the transfer, prosthetic enhancement and erasure of memory. These efforts could have a tremendous impact on a wide range of individuals, from those struggling with memory impairments to those enduring traumatic memories, and they also have broad social and ethical implications.

In the recent study, the natural memory was formed by training mice to associate a specific odor (cherry blossoms) with a foot shock, which they learned to avoid by passing down a rectangular test chamber to another end that was infused with a different odor (caraway). The caraway scent came from a chemical called carvone, while the cherry blossom scent came from another chemical, acetophenone. The researchers found that acetophenone activates a specific type of receptor on a discrete type of olfactory sensory nerve cell.

Saying goodbye to the warm summer months is a little easier when it also means the war against mosquito bites is coming to an end. They’re not just an itchy annoyance, however, mosquitoes can spread dangerous diseases and viruses, but researchers at Brown University might have come up with the perfect mosquito forcefield: garments lined with graphene.

Today, thanks to remarkable advances in antiretroviral drugs, most people with the human immunodeficiency virus (HIV) can expect to live an almost normal lifespan. But that means staying on medications for life. If those are stopped, HIV comes roaring back in just weeks. Finding a permanent cure for HIV infection, where the virus is completely and permanently eliminated from the body, has proven much tougher. So, I’m encouraged by recent work that shows it may be possible to eliminate HIV in a mouse model, and perhaps—with continued progress—someday we will actually cure HIV in humans.

This innovative approach relies on a one-two punch: drugs and genetic editing. First, HIV-infected mice received an experimental, long-acting form of antiretroviral therapy (ART) that suppresses viral replication. This step cleared the active HIV infection. But more was needed because HIV can “hide” by inserting its DNA into its host’s chromosomes—lying dormant until conditions are right for viral replication. To get at this infectious reservoir, researchers infused the mice with a gene-editing system designed to snip out any HIV DNA still lurking in the genomes of their spleen, bone marrow, lymph nodes, and other cells. The result? Researchers detected no signs of HIV in more than one-third of mice that received the combination treatment.

The new study in Nature Communications is the product of a collaboration between the NIH-funded labs of Howard Gendelman, University of Nebraska Medical Center, Omaha, and Kamel Khalili, Temple University, Philadelphia [1]. A virologist by training, Khalili years ago realized that HIV’s ability to integrate into the genomes of its host’s cells meant that the disease couldn’t be thought of only as a typical viral infection. It had a genetic component too, suggesting that an HIV cure might require a genetic answer.

How about some life extension optimism to start your day?

People 50 and older have a lot to look forward to, according to Juvenescence’s Greg Bailey—mainly that we won’t be aging as fast or poorly as our parents. “Science fiction has become science,” said the UK-based anti-aging biotech’s CEO about the company’s completing its $100 million Series B round of financing last week. “I think the world is going to be shocked,” he said in an interview. In total, Juvenescence has now raised $165 million in just 18 months to fund longevity projects with the lofty goal of extending human lifespans to 150 years.