Lifeboat Foundation

A newly developed technique that shows artery clogging fat-and-protein complexes in live fish gave investigators from Carnegie, Johns Hopkins University, and the Mayo Clinic a glimpse of how to study heart disease in action. Their research, which is currently being used to find new drugs to fight cardiovascular disease, is now published in Nature Communications.

Fat molecules, also called lipids, such as cholesterol and triglycerides are shuttled around the circulatory system by a protein called Apolipoprotein-B, or ApoB for short. These complexes of lipid and protein are called lipoproteins but may be more commonly known as “bad cholesterol.”

Sometimes this fat-and-cholesterol ferrying apparatus stops in its tracks and embeds itself in the sides of blood vessels, forming a dangerous buildup. Called plaque, these deposits stiffen the wall of an artery and makes it more difficult for the heart to pump blood, which can eventually lead to a heart attack.

A wireless, wearable monitor built with stretchable electronics could allow comfortable, long-term health monitoring of adults, babies and small children without concern for skin injury or allergic reactions caused by conventional adhesive sensors with conductive gels.

The soft and conformable monitor can broadcast electrocardiogram (ECG), heart rate, respiratory rate and motion activity data as much as 15 meters to a portable recording device such as a smartphone or tablet computer. The electronics are mounted on a stretchable substrate and connected to gold, skin-like electrodes through printed connectors that can stretch with the medical film in which they are embedded.

“This health monitor has a key advantage for young children who are always moving, since the soft conformal device can accommodate that activity with a gentle integration onto the skin,” said Woon-Hong Yeo, an assistant professor in the George Woodruff School of Mechanical Engineering and Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology. “This is designed to meet the electronic health monitoring needs of people whose sensitive skin may be harmed by conventional monitors.”

Understanding how antibiotic scaffolds are constructed in nature can help scientists prospect for new classes of antibiotics through DNA sequencing and genome mining. Researchers have used this knowledge to help solve the X-ray crystal structure of the enzyme that makes obafluorin—a broad spectrum antibiotic agent made by a fluorescent strain of soil bacteria. The new work from Washington University in St. Louis and the University at Buffalo is published July 31 in the journal Nature Communications.

A multi-part enzyme called a nonribosomal peptide synthetase produces the highly reactive beta-lactone ring that is responsible for obafluorin’s antimicrobial activity.

“Obafluorin has a novel structure compared to all FDA-approved antibiotics,” said Timothy Wencewicz, assistant professor of chemistry in Arts & Sciences. “In the long term, we really need new structural classes of antibiotics that have never been contaminated by clinical resistance from established antibiotic classes.”

According to Public Health England, l iver disease is a devastating all too common condition. It is the fifth biggest killer in the UK and the third most common cause of premature death and it is on the rise.

Regenerating liver tissue

Now, researchers at King’s College London may have found a solution to this disease. The scientists have used single cell RNA sequencing to identify a type of cell that may be able to effectively regenerate liver tissue.

As promised, we’re releasing videos from Ending Age-Related Diseases 2019, our highly successful two-day conference that featured talks from leading researchers and investors, bringing them together to discuss the future of aging and rejuvenation biotechnology.

To open the proceedings, our president, Keith Comito, welcomed attendees, introduced the event’s speakers and sponsors, discussed the staff, goals, and projects of LEAF, talked about the advances in rejuvenation biotechnology, and brought forward many more topics in the world of healthy longevity.

Construction progressing at fast clip at 1,210-acre Google site in Tahoe Reno Industrial Center just east of Reno-Sparks.

The co-inventor of the groundbreaking gene editing technology talks to OneZero about a world where illness could be diagnosed in minutes.

We sought to determine whether pre-eclampsia, spontaneous preterm birth or the delivery of infants who are small for gestational age were associated with the presence of bacterial DNA in the human placenta. Here we show that there was no evidence for the presence of bacteria in the large majority of placental samples, from both complicated and uncomplicated pregnancies. Almost all signals were related either to the acquisition of bacteria during labour and delivery, or to contamination of laboratory reagents with bacterial DNA. The exception was Streptococcus agalactiae (group B Streptococcus), for which non-contaminant signals were detected in approximately 5% of samples collected before the onset of labour. We conclude that bacterial infection of the placenta is not a common cause of adverse pregnancy outcome and that the human placenta does not have a microbiome, but it does represent a potential site of perinatal acquisition of S. agalactiae, a major cause of neonatal sepsis.

A technique called Hybrid 3D Printing, developed by AFRL researchers in collaboration with the Wyss Institute at Harvard University, uses additive manufacturing to integrate soft, conductive inks with material substrates to create stretchable electronic devices. A potential application is to create sensors to enable better human performance monitoring. (Courtesy photo/Harvard Wyss Institute)

https://www.wpafb.af.mil/…/afrl-harvard-researchers-invent…/

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