Lifeboat Foundation

One of the most difficult challenges in treating the brain cancer glioblastoma is that few drugs can pass through the blood-brain barrier. Scientists at Cedars-Sinai in Los Angeles have developed a system to circumvent this hurdle—one that combines a powerful immuno-oncology drug with a polymer-based delivery vehicle that can cross the blood-brain barrier.

The researchers showed that this “nano-immunotherapy” treatment crossed the blood-brain barrier in mouse models of glioblastoma, and that it stopped tumor cells from multiplying. They published their findings in the journal Nature Communications.

The Cedars-Sinai team used the polymer scaffold to deliver two types of immune checkpoint inhibitors, blocking either CTLA-4 or PD-1. When injected into the bloodstream of mice, the drugs quickly infiltrated brain tumors, but not healthy brain tissue, the researchers reported.

https://youtu.be/qyQNZMPZLtU

The heaviest mantle of bees weighed 62.1 kg (136 lb 14.51 oz) and was achieved by Ruan Liangming (China) in Fengxin County, Jiangxi Province, China, on 6 May 2012.

Each week, we bring you jaw dropping records both old and new from our Guinness World Records video archive!

Continue reading “MAN COVERED IN BEES! — Classics” »

The #USOpen starts today! Can you imagine a spacecraft the size of a tennis court? To see infrared light from faraway objects, the James Webb Space Telescope needs to be extremely cold! Enter Webb €™s sunshield (~21x14 meters in size), which will provide shade and keep Webb operating at less than ~50 Kelvin (−370 °F or −223 °C).

https://go.nasa.gov/2zfNzYP

Researchers have successfully created a model of the Universe using artificial intelligence, reports a new study.

Researchers seek to understand our Universe by making model predictions to match observations. Historically, they have been able to model simple or highly simplified physical systems, jokingly dubbed the “spherical cows,” with pencils and paper. Later, the arrival of computers enabled them to model complex phenomena with numerical simulations. For example, researchers have programmed supercomputers to simulate the motion of billions of particles through billions of years of cosmic time, a procedure known as the N-body simulations, in order to study how the Universe evolved to what we observe today.

“Now with machine learning, we have developed the first neural network model of the Universe, and demonstrated there’s a third route to making predictions, one that combines the merits of both analytic calculation and numerical simulation,” said Yin Li, a Postdoctoral Researcher at the Kavli Institute for the Physics and Mathematics of the Universe, University of Tokyo, and jointly the University of California, Berkeley.

The Defense Advanced Research Projects Agency (DARPA) puts out lots of public requests for scientific research, including high-profile competitions involving robotics and space launch tech. But today, the agency tweeted a very simple plea: it needs a massive, maze-like underground facility for running experiments, and it needs it right now.

She’s now leading her own $39m Longevity Fund that supports entrepreneurs developing therapies for age-related diseases.

Born in New Zealand, Deming was home-schooled by her parents but as a child taught herself calculus, probability and statistics as well as French literature and history.

After her grandmother Bertie developed neuro-muscular problems in her 70s and 80s, she decided to dedicate her life to combating the ageing process.

The rise of cryptocurrency is changing the philanthropic world by causing the redistribution of wealth from old money to visionary innovators and early tech adopters. The new crypto rich invest their donations by supporting scientific research in groundbreaking fields that may one day enable humanity to cure aging, reverse death and completely change the relationship between work and income.

Also Read: How Does a Country Do an ICO? They Call It QE

Examining the record of donations made by the crypto rich reveals a pattern of support for goals that others may feel belong in the pages of science fiction novels. Having benefited greatly from recognizing the potential of peer to peer electronic cash earlier than the masses, it is no surprise that they have great optimism in the power of technology to radically change our lives for the better.

As destructive natural phenomena go, hurricanes are among the heavyweights. If not for the gale-force winds and resulting projectile debris, then for the massive flooding that results when one makes landfall and stalls out, a hurricane is a nasty piece of work. Just ask the residents of the coastal Carolinas and Georgia this week as they wring themselves out from Hurricane Matthew’s weekend deluge.

The story of a generation comes to an end. Watch the D23 Special Look for Star Wars: #TheRiseofSkywalker. See the film in theaters on December 20.