Lifeboat Foundation

Circa 2019

Airless tires for everyday cars might soon be far more practical. GM and Michelin have unveiled a prototype of Uptis (Unique Puncture-proof Tire System), a Michelin-made tire intended for passenger cars. It looks like Tweel and other air-free concepts of years past, but its mix of composite rubber and resin embedded fiberglass lets it operate at highway speeds — earlier options tend to work only when you’re slowly putting around. It’s not as visually appealing as conventional tires, but Michelin claims it’s just as comfortable.

Continue reading “GM and Michelin will bring airless tires to passenger cars by 2024” »

Various stem cell sources are being explored to treat diabetes since the proof-of-concept for cell therapy was laid down by transplanting cadaveric islets as a part of Edmonton protocol in 2000. Human embryonic stem (hES) cells derived pancreatic progenitors have got US-FDA approval to be used in clinical trials to treat type 1 diabetes mellitus (T1DM). However, these progenitors more closely resemble their foetal counterparts and thus whether they will provide long-term regeneration of adult human pancreas remains to be demonstrated. In addition to lifestyle changes and administration of insulin sensitizers, regeneration of islets from endogenous pancreatic stem cells may benefit T2DM patients. The true identity of pancreatic stem cells, whether these exist or not, whether regeneration involves reduplication of existing islets or ductal epithelial cells transdifferentiate, remains a highly controversial area. We have recently demonstrated that a novel population of very small embryonic-like stem cells (VSELs) is involved during regeneration of adult mouse pancreas after partial-pancreatectomy. VSELs (pluripotent stem cells in adult organs) should be appreciated as an alternative for regenerative medicine as these are autologous (thus immune rejection issues do not exist) with no associated risk of teratoma formation. T2DM is a result of VSELs dysfunction with age and uncontrolled proliferation of VSELs possibly results in pancreatic cancer. Extensive brainstorming and financial support are required to exploit the potential of endogenous VSELs to regenerate the pancreas in a patient with diabetes.

Diabetes is one of the major non-communicable diseases in the world with majority of patients belonging to India, China and USA. Along with associated complications like heart disease and stroke, diabetes results in increased morbidity and mortality and it is expected that by the year 2025, India alone will have more than 70 million diabetics^1,2. Diabetes is a metabolic disorder associated with progressive loss or dysfunction of β-cells of pancreas. Onset of type 1 diabetes mellitus (T1DM) occurs when the β-cell mass is reduced to less than 20 per cent due to autoimmune effect, whereas the declining β-cell mass is unable to meet the age-related increased insulin demands of the body in type 2 (T2DM) as a result of insulin resistance and in due course the β-cells are lost by apoptosis. Thus, in both T1 and T2DM, restoration of a functional β-cell mass constitutes the central goal of diabetes therapy.

In a study involving mice, researchers have determined that the amygdala, a part of the temporal lobe, could turn off pain signals in the brain. To learn more, click the link above and watch a video further explaining the functions of the amygdala.

Millions of people in India and Bangladesh are in the path of a cyclone which is due to make landfall in less than 36 hours, bringing damaging winds and heavy rain to a region already struggling with the coronavirus pandemic.

Super Cyclone Amphan became the strongest storm ever recorded in the Bay of Bengal on Monday night, after intensifying with sustained wind speeds of up to 270 kilometers per hour (165 miles per hours), according to data from the US Joint Typhoon Warning Center.

Amphan has weakened slightly since, but the storm is still the equivalent of a Category 3 Atlantic hurricane, with winds speeds up to 185 kph (115 mph).

Stylish. Iconic. It’s you. It’s also the Worm. Designer Richard Danne shares the history of the inspiring design.

Your Worm swag using #TheWormIsBack and show us how pumped you are to #LaunchAmerica on May 27: https://youtu.be/IwrtrxiwXTE

Moderna has accelerated its manufacturing capacity for its COVID-19 vaccine candidate mRNA-1273 and additional future products through a 10-year agreement with Lonza announced today by the companies.

The companies agreed to establish manufacturing suites for Moderna at Lonza’s facilities in the U.S. and Switzerland for the production of mRNA-1273. Technology transfer is expected to begin in June, with the first batches of mRNA-1273 set to be manufactured at Lonza’s U.S. site in July.

Moderna and Lonza also said they intend to establish additional production suites across Lonza’s worldwide facilities, ultimately allowing for the manufacture of material equivalent to up to 1 billion doses of mRNA-1273 per year for use worldwide, based on the currently expected dose of 50 mcg.

A bit of transhuman fiction. It doesn’t take long.

What would it be like to live forever? Writer Richard Dooling explores this question in this fictional piece from Esquire.

Originally published May 1999. Published on KurzweilAI.net May 22, 2001.

1994

Continue reading “Diary of an Immortal Man” »

Scientists are using light waves to accelerate supercurrents and access the unique properties of the quantum world, including forbidden light emissions that one day could be applied to high-speed, quantum computers, communications and other technologies.

The scientists have seen unexpected things in supercurrents—electricity that moves through materials without resistance, usually at super cold temperatures—that break symmetry and are supposed to be forbidden by the conventional laws of physics, said Jigang Wang, a professor of physics and astronomy at Iowa State University, a senior scientist at the U.S. Department of Energy’s Ames Laboratory and the leader of the project.

Wang’s lab has pioneered use of light pulses at terahertz frequencies- trillions of pulses per second—to accelerate electron pairs, known as Cooper pairs, within supercurrents. In this case, the researchers tracked light emitted by the accelerated electrons pairs. What they found were “second harmonic light emissions,” or light at twice the frequency of the incoming light used to accelerate electrons.

Then there is the COVID-19 Open Research Dataset (CORD-19), a multi-institutional initiative that includes The White House Office of Science and Technology Policy, Allen Institute for AI, Chan Zuckerberg Initiative (CZI), Georgetown University’s Center for Security and Emerging Technology (CSET), Microsoft, and the National Library of Medicine (NLM) at the National Institutes of Health (NIH).

The goal of this initiative is to create new natural language processing and machine learning algorithms to scour scientific and medical literature to help researchers prioritize potential therapies to evaluate for further study. AI is also being used to automate screening at checkpoints by evaluating temperature via thermal cameras, as well as modulations in sweat and skin discoloration. What’s more, AI-powered robots have even been used to monitor and treat patients. In Wuhan, the original epicenter of the pandemic, an entire field hospital was transitioned into a “smart hospital” fully staffed by AI robotics.

Any time of great challenge is a time of great change. The waves of technological innovation that are occurring now will echo throughout eternity. Science, technology, engineering and mathematics are experiencing a call to mobilization that will forever alter the fabric of discovery in the fields of bioengineering, biomimicry and artificial intelligence. The promise of tomorrow will be perpetuated by the pangs of today. It is the symbiosis of all these fields that will power future innovations.