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Apr 17, 2020

Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD)

Posted by in category: biotech/medical

Lysergic acid diethylamide (LSD) is a prototypical serotonergic psychedelic drug and the subject of many clinical investigations. In recent years, a range of lysergamides has emerged with the production of some being inspired by the existing scientific literature. Others, for example various 1-acyl substituted lysergamides, did not exist before their appearance as research chemicals. 1-Cylopropanoyl-LSD (1CP-LSD) has recently emerged as a new addition to the group of lysergamide-based designer drugs and is believed to be psychoactive in humans. In this investigation, 1CP-LSD was subjected to detailed analytical characterizations including various mass spectrometry (MS) platforms, gas and liquid chromatography, nuclear magnetic resonance spectroscopy, solid phase and GC condensed phase infrared spectroscopy. Analysis by GC-MS also revealed the detection of artificially induced degradation products. Incubation of 1CP-LSD with human serum led to the formation of LSD, indicating that it may act as a prodrug for LSD in vivo, similar to other 1-acyl substituted lysergamides. The analysis of blotters and pellets is also included. 1CP-LSD also induces the head-twitch response (HTR) in C57BL/6J mice, indicating that it produces an LSD-like behavioural profile. 1CP-LSD induced the HTR with an ED50 = 430.0 nmol/kg which was comparable with 1P-LSD (ED50 = 349.6 nmol/kg) investigated previously. Clinical studies are required to determine the potency and profile of effects produced by 1CP-LSD in humans.

This article is protected by copyright. All rights reserved.

PMID: 32180350 DOI: 10.1002/dta.

Apr 17, 2020

Frontiers & IUIS Collaborate on COVID-19 Video & Webinar Series

Posted by in category: biotech/medical

Faith Osier, President of the IUIS — International Union of Immunological Societies, calls on researchers to share knowledge and resources to halt the coronavirus (COVID-19) pandemic, as she launches an expert commentary and webinar series on scientific and civil responses to the outbreak.

See all interviews: https://fro.ntiers.in/yDH4

Apr 17, 2020

Italy: Stromboli erupts for second time in one month

Posted by in category: climatology

👽Stromboli has just erupted again for the second time this month. There has been 8000 earthquakes since January 2020 in Iceland, coinciding with a volcano network that has not been awake for 800 years.

There has been 250 small Earthquakes in Idaho, and the most recent relatively strong quake worldwide was registered in Honduras, over 6,3 magnitude, yesterday.

Continue reading “Italy: Stromboli erupts for second time in one month” »

Apr 17, 2020

After Anonymous Tip, 17 Bodies Found at Nursing Home Hit by Virus

Posted by in category: biotech/medical

There have been 68 recent deaths of residents and nurses from the facility in a small New Jersey town.

Apr 17, 2020

Phase-change fabric both warms and cools its wearer

Posted by in category: materials

The more clothing that you wear, the warmer you are … right? Well actually, scientists have developed a new textile that both warms wearers in cold environments, and cools them down when things heat up.

The experimental material was developed at China’s Huazhong University of Science and Technology, by a team led by Prof. Guangming Tao. It’s made by first freeze-spinning silk and chitosan, forming fibers with a porous microstructure – chitosan, incidentally, is a highly useful natural compound found in crustacean shells.

Next, the pores within the fibers are filled with polyethylene glycol (PEG), which is a phase-change material that takes the form of a liquid when warm, and a solid when cool. Finally, the fibers are coated with an organic polymer known as polydimethylsiloxane, to keep the PEG from leaking out while in its liquid state.

Apr 17, 2020

Fyodor Rouge Photo

Posted by in category: futurism

Apr 17, 2020

‘DO NOT click the link’; Police warn of scam COVID-19 text messages

Posted by in categories: biotech/medical, cybercrime/malcode, mobile phones

Scam alert.


THOMASTON, Me. (WSET) — Police are warning cell phone users of a new text message scam during the coronavirus pandemic. The Thomaston Police Department in Maine posted on Facebook a photo of the alert being sent to people in a text message. The message was sent to someone in Maine from an Indiana area code telling them they need to self-isolate because they came in contact with someone who tested positive or has shown symptoms for coronavirus. The alert also tells you to get tested.

Apr 16, 2020

MDMA-Assisted Psychotherapy

Posted by in categories: biotech/medical, education, law, neuroscience

Founded in 1986, the Multidisciplinary Association for Psychedelic Studies (MAPS) is a 501©(3) non-profit research and educational organization that develops medical, legal, and cultural contexts for people to benefit from the careful uses of psychedelics and marijuana. MAPS furthers its mission by: Developing psychedelics and marijuana into prescription medicines; Training therapists and working to establish a network of treatment centers; Supporting scientific research into spirituality, creativity, and neuroscience; and educating the public honestly about the risks and benefits of psychedelics and marijuana.

Apr 16, 2020

Multiple scientific studies suggest smoking may PROTECT against coronavirus

Posted by in category: biotech/medical

Another study, by America’s Centers for Disease Control of over 7,000 people who tested positive for coronavirus, found that just 1.3 per cent of them were smokers — against the 14 per cent of all Americans that the CDC says smoke.

The study also found that the smokers stood no greater chance of ending up in hospital or an ICU.

The reasons for this are unclear.

Apr 16, 2020

Scientists are recommending MDMA for treating mental health after lockdown

Posted by in category: neuroscience

The use of psilocybin is also being called for.