Lifeboat Foundation

Sleep loss is no longer considered an emblem of productivity or success—research has shown over and over that it’s one of the worst things we can do for ourselves. The body may not need sleep so much, but the brain sure does: a huge amount of housekeeping is done while we’re sleeping, and losing sleep, especially chronically, prevents this essential work. Two new studies illustrate what sleep loss does to our thinking skills the next day and to the brain’s ability to clear out potentially dangerous “gunk.”

The first study, from Michigan State University, had 77 people stay awake all night in the lab and 63 go home and sleep normally. All the participants were rested before the study began, and then separated into their respective groups for one night of sleep deprivation or normal rest. The researchers gave them tests of attention (the Psychomotor Vigilance Task) and cognition (the UNRAVEL method, which involves having to keep track of a series of steps in the face of period interruptions) in the evening and again the following morning.

The sleep-deprived participants did conspicuously worse on the tests than the rested ones: The evening before, there was about a 15% error rate after interruptions on the UNRAVEL test, which the next morning rose to 30%. In contrast, the rested group performed about the same in the evening before and the morning after. The sleep-deprived also had significantly more lapses in attention the morning after, compared to the rested group.

In 1900, so the story goes, prominent physicist Lord Kelvin addressed the British Association for the Advancement of Science with these words: “There is nothing new to be discovered in physics now.”

How wrong he was. The following century completely turned physics on its head. A huge number of theoretical and experimental discoveries have transformed our understanding of the universe, and our place within it.

Don’t expect the next century to be any different. The universe has many mysteries that still remain to be uncovered—and new technologies will help us to solve them over the next 50 years.

Insects typically have a variety of complex exoskeleton structures, which support them in their movements and everyday activities. Fabricating artificial exoskeletons for insect-inspired robots that match the complexity of these naturally-occurring structures is a key challenge in the field of robotics.

Although researchers have proposed several fabrication processes and techniques to produce exoskeletons for insect-inspired robots, many of these methods are extremely complex or rely on expensive equipment and materials. This makes them unfeasible and difficult to apply on a wider scale.

With this in mind, researchers at the University of California in San Diego have recently developed a new process to design and fabricate components for insect-inspired robots with exoskeleton structures. They introduced this process, called flexoskeleton printing, in a paper prepublished on arXiv.

Anzalone’s prime editor is a little different. Its enzyme is actually two that have been fused together—a molecule that acts like a scalpel combined with something called a reverse transcriptase, which converts RNA into DNA. His RNA guide is a little different too: It not only finds the DNA in need of fixing, but also carries a copy of the edit to be made. When it locates its target DNA, it makes a little nick, and the reverse transcriptase starts adding the corrected sequence of DNA letter by letter, like the strikers on a typewriter.

A less error-prone DNA editing method could correct many more harmful mutations than was previously possible.

We’ve long known that viruses can target cancers in our bodies. Now, thanks to gene editing, we’re using them as tumour search and destroy agents – and getting our immune systems to join the fight too.

It has long been understood, and by cultures too various to list, that salamanders have something of the supernatural about them. Their name is thought to derive from an ancient Persian vocable meaning ‘fire within’, and for at least 2,000 years they were believed to be impervious to flames, or even capable of extinguishing them on contact. Aristotle recorded this exceptional characteristic, as did Leonardo da Vinci. The Talmud advises that smearing salamander blood on your skin will confer inflammability. Not so. But the intuition that salamanders possess fantastical powers is not unfounded.

Like earthbound immortals, salamanders regenerate. If you cut off a salamander’s tail, or its arm, or its leg, or portions of any of these, it will not form a stump or a scar but will instead replace the lost appendage with a perfect new one, an intricacy of muscle, nerve, bone and the rest. It will sprout like a sapling. Science has been chopping up salamanders for more than 200 years with the aim of simply understanding the mechanics of their marvels, but more recently with the additional aim of someday replicating those marvels in ourselves. Might salamanders be the great hope of regenerative medicine?

The salamander in which regeneration is most often studied is an odd and endearingly unattractive Mexican species known as the axolotl. In addition to its limbs and extremities, the axolotl is known to regrow its lower jaw, its retinae, ovaries, kidneys, heart, rudimentary lungs, spinal cord, and large chunks of its brain. It heals all sorts of wounds without scarring. The axolotl also integrates the body parts of its fellows as if they were its own, without the usual immune response, and this peculiar trait has facilitated some of the more grotesque disfigurements it’s endured in the name of science. In experiments after the Second World War, East German scientists grafted small axolotls crosswise through the backs of larger ones. The animals’ circulatory systems came to be linked, and the researchers hailed the conjoined mutants as triumphs of collectivism.

Lo sviluppo di biorobot autonomi compie un passo avanti grazie allo sviluppo di dispositivi robotici morbidi guidati dal tessuto neuromuscolare. Creati da un gruppo di ricerca dell’ Università dell’Illinois con a capo il professore di ingegneria meccanica e scienze meccaniche Taher Saif e il professore di bioingegneria Rashid Bashir, sono i primi biorobot semiautomatici capaci di muoversi autonomamente.

Thank you for watching this powerful interview with Dave Asprey!
Check out the show notes here: https://www.lewishowes.com/860

Dave Asprey is the creator of the widely-popular Bulletproof Coffee, host of the podcast Bulletproof Radio, and author of the New York Times bestselling book, The Bulletproof Diet.

Continue reading “Age Backwards, Biohack Your Life and Be Superhuman | Dave Asprey and Lewis Howes” »

Regular fasting is associated with lower rates of heart failure and a longer life span, according to two new studies.

Researchers sought to shed new light on the centuries-old debate about how fasting affects health. Recent studies have shown it contributes to reductions in blood pressure, “bad” LDL cholesterol and insulin resistance, a condition that can raise blood sugar. A 2017 study showed alternate-day fasting was as effective as daily calorie restriction for losing weight and keeping the pounds off.

The new studies focused on data from patients evaluated for heart disease in Utah and other Rocky Mountain states. The research included hundreds of members of The Church of Jesus Christ of Latter-day Saints, also known as Mormons, who typically fast one Sunday each month, for up to 24 hours.