Menu

Blog

Page 6

Mar 17, 2024

Tooth agenesis tied to early-onset cancer in early childhood and early adulthood: JAMA

Posted by in category: biotech/medical

Denmark: A recent study published in JAMA Network Open has suggested an association between tooth agenesis and specific cancer types, specifically in childhood and early adulthood.

“Our population-based cohort study of 2.5 million live-born singletons with up to 40 years of follow-up showed that tooth agenesis was positively associated with several cancer types, including nephroblastoma, neuroblastoma, and hepatoblastoma in childhood; osteosarcoma in adolescence; and carcinomas of the bladder and colorectal carcinomas in young adulthood,” the researchers reported.

Previous studies have provided some evidence that tooth agenesis (congenital absence of one or more teeth) is associated with cancer risk, particularly carcinomas of the ovaries and colon, but these results are conflicting, and associations have not been evaluated yet in a population-based setting. To fill this knowledge gap, Saga Elise Eiset, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, and colleagues aimed to investigate the association between tooth agenesis and specific cancer types before 40 years of age.

Mar 17, 2024

Diabetes Medication Raises Safety Concerns in Surgery

Posted by in categories: biotech/medical, food

Diabetic medication has garnered popularity within the last few years. It is not necessarily the need for these medications that is associated with its popularity, but a side effect that most individuals desire: weight loss. Since the advent of drugs that promote rapid weight loss such as Ozempic, Mounjaro, and Wegovy, widespread safety concerns are being raised regarding long-term effects and more immediate risks such as complications during surgery.

Ozempic, Mounjaro, and Wegovy are all part of a class of drugs known as semaglutides, which are glucagon-like peptide-1 receptor agonists or GLP1-RAs. GLP1 receptors are expressed on different cells within tissues and organs including the pancreas. GLP1-RAs help the pancreas release insulin and lower blood sugar levels, which makes these medications very helpful for those with diabetes. However, the stomach also has GLP1 receptors. Consequently, it activates these receptors as well and causes the stomach to digest food at a much slower rate. This delayed gastric emptying results in patients feeling full and not eating as much to lose weight. Additionally, previous literature has found that patients on GLP1-RAs have lower risk of adverse cardiovascular effects, such as heart attack. However, there are limitations to this medication associated with surgery.

Surgeons ask patients to fast before a surgery for a myriad of reasons all pertaining to the safety and success of the surgery. One reason includes that under anesthesia any remaining food in the stomach can come up and flow into the trachea leading to a life-threatening condition referred to as “aspiration pneumonitis”. Physicians and scientists are currently working to avoid this event from occurring and are investigating the risk of aspiration pneumonitis in patients.

Mar 17, 2024

Is plasma CA-125 linked to post-extubation respiratory failure?

Posted by in category: biotech/medical

Recently published study investigated the association between plasma CA-125 levels and post-extubation respiratory failure (PERF) in critically ill patients. A prospective cohort study was conducted in a tertiary hospital, enrolling patients aged 18 years or older who had received mechanical ventilation (MV) for at least 48 hours. The study found that among the 103 enrolled patients, 44 (51.2%) experienced PERF, with 23 receiving non-invasive ventilation and 16 requiring reintubation within 72 hours. Patients who experienced respiratory failure showed significantly higher median CA-125 values compared to those without respiratory failure. The area under the ROC curve for CA-125 in predicting respiratory failure occurrence was 0.663, and CA-125 levels exceeding 35.0 U/mL were found to be significantly associated with the occurrence of respiratory failure in a logistic regression model. A post-hoc analysis combining CA-125 and lung ultrasound (LUS) scores showed an 81.0% incidence of respiratory failure in patients with elevated CA-125 and LUS scores, while patients with normal CA-125 and LUS scores had a markedly lower incidence of 32.0% for respiratory failure. The study suggests the potential utility of incorporating CA-125 into routine congestion assessments and reveals a potential role for combining CA-125 with LUS scores to evaluate a patient’s risk of developing PERF. The authors concluded that elevated CA-125 levels were associated with a higher incidence of respiratory failure among critically ill patients who were extubated following successful spontaneous breathing trials. The study highlighted the potential application of CA-125 in assessing and predicting respiratory outcomes in critically ill patients, particularly in the context of extubation. The findings hold implications for clinical practice, indicating the need for further research and potential incorporation of CA-125 into routine assessment protocols for critically ill patients in intensive care units.

Reference –

Lombuli, F., Montes, T.H.M. & Boniatti, M.M. Association between CA-125 and post-extubation respiratory failure: a cohort study. Crit Care 28, 31 (2024). https://doi.org/10.1186/s13054-024-04806-5

Mar 17, 2024

Tesla reiterates ease of EV charging for home and during long trips

Posted by in categories: mobile phones, sustainability, transportation

Even if electric cars are already prevalent today, anti-EV narratives are still abounding. Among the most persistent anti-electric vehicle talking points involves the idea that EVs take hours to charge, so those who own them would be stuck waiting several hours waiting for their cars to “fill up.” A recent post from Tesla’s official social media handle debunks these ideas.

Longtime Tesla and electric vehicle owners have noted over the years that EV charging practices are far different from refueling a combustion-powered car. As the electric vehicle maker posted on its official handle on X, the social media platform formerly known as Twitter, charging a Tesla is actually far simpler than expected.

When charging at home through a Wall Connector or Mobile Connector, for example, all Tesla owners need to do is plug in their cars when they pull into their garage. EVs are like gigantic mobile devices, so just like smartphones, they could simply charge their batteries while their owners go about their day. And with the Wall Connector or Mobile Connector, Tesla owners can typically wake up to a fully charged car per day.

Mar 17, 2024

‘Feels like magic!’: Groq’s ultrafast LPU could well be the first LLM-native processor — and its latest demo may well convince Nvidia and AMD to get out their checkbooks

Posted by in category: robotics/AI

Groq’s ultrafast Language Processing Unit (LPU) could be a game-changer for AI.

Mar 17, 2024

Sam Eckholm on Instagram: ‘The $400,000 helmet for the F-35 Lightning! 😱’

Posted by in categories: climatology, military

171K likes, — sameckholm on March 8, 2024: ‘The $400,000 helmet for the F-35 Lightning! 😱’

Mar 17, 2024

Entanglion, a quantum computing board game developed by @IBMQuantum

Posted by in categories: business, computing, entertainment, quantum physics

https://entanglion.github.io


Congratulations, your captain has retired and left you in charge of his galactic shipping business! Now it’s time to make some upgrades as you embark on a journey to reconstruct a quantum computer developed by an ancient race.

Entanglion is a cooperative board game designed for two players. Learn about quantum computing as you work together with your teammate to navigate the three galaxies of the quantum universe, avoid detection by the defense mechanisms left behind by the ancients, and rebuild the quantum computer.

Continue reading “Entanglion, a quantum computing board game developed by @IBMQuantum” »

Mar 17, 2024

How to Destroy a Nuke Anywhere on Earth

Posted by in categories: biotech/medical, military

Use code coolworlds at https://incogni.com/coolworlds to get an exclusive 60% off an annual Incogni plan. Nuclear weapons are the most terrifying invention of humanity. Could our genius to create such weapons also end them? Today we explore how neutrinos could be used to do just that, fizzling out nukes anywhere on Earth and with no defense. Written & presented by Prof. David Kipping, edited by Jorge Casas. Special thanks to Sam Gregson ( / @badboyofscience) for fact checking. → Support our research: https://www.coolworldslab.com/support → Get merch: https://teespring.com/stores/cool-wor… Check out our podcast: / @coolworldspodcast THANK-YOU to D. Smith, M. Sloan, L. Sanborn, C. Bottaccini, D. Daughaday, A. Jones, S. Brownlee, N. Kildal, Z. Star, E. West, T. Zajonc, C. Wolfred, L. Skov, G. Benson, A. De Vaal, M. Elliott, B. Daniluk, S. Vystoropskyi, S. Lee, Z. Danielson, C. Fitzgerald, C. Souter, M. Gillette, T. Jeffcoat, J. Rockett, D. Murphree, T. Donkin, K. Myers, A. Schoen, K. Dabrowski, J. Black, R. Ramezankhani, J. Armstrong, K. Weber, S. Marks, L. Robinson, S. Roulier, B. Smith, J. Cassese, J. Kruger, S. Way, P. Finch, S. Applegate, L. Watson, E. Zahnle, N. Gebben, J. Bergman, E. Dessoi, C. Macdonald, M. Hedlund, P. Kaup, C. Hays, W. Evans, D. Bansal, J. Curtin, J. Sturm, RAND Corp., M. Donovan, N. Corwin, M. Mangione, K. Howard, L. Deacon, G. Metts, R. Provost, B. Sigurjonsson, G. Fullwood, B. Walford, J. Boyd, N. De Haan, J. Gillmer, R. Williams, E. Garland, A. Leishman, A. Phan Le, R. Lovely, M. Spoto, A. Steele, K. Yarbrough, A. Cornejo, D. Compos, F. Demopoulos, G. Bylinsky, J. Werner, B. Pearson, S. Thayer, T. Edris, B. Seeley, F. Blood, M. O’Brien, P. Muzyka, D. Lee, J. Sargent, M. Czirr, F. Krotzer, I. Williams, J. Sattler, J. Smallbon, B. Reese, J. Yoder, O. Shabtay, X. Yao, S. Saverys, M. Pittelli, A. Nimmerjahn & C. Seay. CHAPTERS 0:00 Neutrinos 3:39 Incogni 5:08 Neutrino Factories 9:11 Applications 14:19 My Take 16:17 Outro & Credits #nuclearwar #nuke #coolworlds

Mar 17, 2024

Scientists Reveal How our Cells’ Leaky Batteries are making us Sick

Posted by in categories: biotech/medical, genetics, life extension

The new findings could lead to better treatments for rheumatoid arthritis, lupus and other inflammatory diseases – and may even help us slow aging.

Researchers have discovered how “leaky” mitochondria can drive harmful inflammation responsible for diseases such as lupus and rheumatoid arthritis. Scientists may be able to leverage the findings to develop better treatments for those diseases, improve our ability to fight off viruses and even slow aging.

The new discovery reveals how genetic material can escape from our cellular batteries, known as mitochondria, and prompt the body to launch a damaging immune response. By developing therapies to target this process, doctors may one day be able to stop the harmful inflammation and prevent the toll it takes on our bodies.

Mar 17, 2024

The Transhumanism Affirmation

Posted by in category: transhumanism

Champion Transhumanism!


Growing misinformation and disinformation about transhumanism by its critics must be identified, addressed, and corrected. Distortions about transhumanism confuse the general public, scholars, and students alike about the central values that guide actions for bettering the conditions of every individual. These distortions spread fear about transhumanist technologies that, in fact, can unleash almost unimaged levels of prosperity, longer, healthier lives, and opportunities for flourishing in a bright future for all.

Page 6 of 10,809First345678910Last