Lifeboat Foundation

On Januray 25th, we will discuss different aspects of longtermism — a concept of effective altruism. To decide which ist the best action to take we usually consider the effects of our actions on the short-or medium-term future — whether we save someone’s life, or mitigate sexism or racism in the next generation. According to longtermism that is wildly mistaken. The value of our actions is determined almost exclusively by their effects on the future in the very long-run — the next millions and billions of years. Their effects on the next 100 or even 1000 years are just about irrelevant. Our everyday thinking is radically short-sighted, and common evaluations perhaps dramatically wrong. In this online meetup, we will look at a compelling justification for longtermism, at its historical roots, and some of its practical implications — e.g. concerning existential risks, or the idea that our time might be the most important in the history of humanity. Free discord session on 9:30 — 11:30 AM PST 11:30 — 13:30 AM DST.

What is the best action we can take? According to longtermism we should consider the effects on the future in the very long run — the next millions and billions of years — to answer this question.

SpaceX will launch its first batch of Starlink satellites in 2021 on Tuesday (Jan. 19) to expand the company’s growing megaconstellation and you can watch the action live online.

Researchers from Tokyo Metropolitan University have discovered that fruit flies with genetic modifications to enhance glucose uptake have significantly longer lifespans. Looking at the brain cells of aging flies, they found that better glucose uptake compensates for age-related deterioration in motor functions, and led to longer life. The effect was more pronounced when coupled with dietary restrictions. This suggests healthier eating plus improved glucose uptake in the brain might lead to enhanced lifespans.

The brain is a particularly power-hungry part of our bodies, consuming 20% of the oxygen we take in and 25% of the glucose. That’s why it’s so important that it can stay powered, using the glucose to produce adenosine triphosphate (ATP), the “energy courier” of the body. This chemical process, known as glycolysis, happens in both the intracellular fluid and a part of cells known as the mitochondria. But as we get older, our brain cells become less adept at making ATP, something that broadly correlates with less glucose availability. That might suggest that more food for more glucose might actually be a good thing. On the other hand, it is known that a healthier diet actually leads to longer life. Unraveling the mystery surrounding these two contradictory pieces of knowledge might lead to a better understanding of healthier, longer lifespans.

A team led by Associate Professor Kanae Ando studied this problem using Drosophila fruit flies. Firstly, they confirmed that brain cells in older flies tended to have lower levels of ATP, and lower uptake of glucose. They specifically tied this down to lower amounts of the enzymes needed for glycolysis. To counteract this effect, they genetically modified flies to produce more of a glucose-transporting protein called hGut3. Amazingly, this increase in glucose uptake was all that was required to significantly improve the amount of ATP in cells. More specifically, they found that more hGut3 led to less decrease in the production of the enzymes, counteracting the decline with age. Though this did not lead to an improvement in age-related damage to mitochondria, they also suffered less deterioration in locomotor functions.

We’ve finally made a room-temperature superconductor, so materials that transport electricity without wasting any of it are within our grasp.

I’m curious what biomarkers people here currently track? I did some research and came up with these 20 but any you would add/take away? (9 of them were mostly included to be able to use Morgan Levine’s biological age calculator).

This is the first article in a two-part series on the best aging biomarkers to track for longevity. The second article will compare different tests and testing companies on the market and supply a sample testing schedule you can use.

Continue reading “20 Best Aging Biomarkers to Track for Longevity” »

This Video Explains Cellular Compartmentation And Protein Sorting (Nuclear Transport, Ran GTPase Cycle)

Thank You For Watching.

Continue reading “Cellular Compartmentation And Protein Sorting (Nuclear Transport, Ran GTPase Cycle) Part 1” »

It all comes down to blocking one key neurotransmitter.

Scientists at the Institute of Physics of the University of Tartu have found a way to develop optical quantum computers of a new type. Central to the discovery are rare earth ions that have certain characteristics and can act as quantum bits. These would give quantum computers ultrafast computation speed and better reliability compared to earlier solutions. The University of Tartu researchers Vladimir Hizhnyakov, Vadim Boltrushko, Helle Kaasik and Yurii Orlovskii published the results of their research in the scientific journal Optics Communications.

While in ordinary computers, the units of information are binary digits or bits, in quantum computers the units are quantum bits or qubits. In an ordinary computer, information is mostly carried by electricity in memory storage cells consisting of field-effect transistors, but in a quantum computer, depending on the type of computer, the information carriers are much smaller particles, for example ions, photons and electrons. The qubit information may be carried by a certain characteristic of this particle (for example, spin of electron or polarization of photon), which may have two states. While the values of an ordinary bit are 0 or 1, also intermediate variants of these values are possible in the quantum bit. The intermediate state is called the superposition. This property gives quantum computers the ability to solve tasks, which ordinary computers are unable to perform within reasonable time.

Moscow has revealed a plan to spend $2.4 million on a giant database containing information about every single city resident, including passport numbers, insurance policies, salaries, car registrations – and even their pets.

It will also include work and tax details, school grades, and data from their ‘Troika’ care – Moscow’s unified transport payment system, used on the metro, busses and trains.

The new proposal will undoubtedly increase fears about ever-growing surveillance in the Russian capital, where the number of facial recognition cameras has recently been increased.