Lifeboat Foundation

Doctors regularly warn their patients that having high levels of triglycerides, a major dietary fat, can increase the risk of heart disease, diabetes, obesity and fatty liver disease. There is considerable interest in finding novel ways to effectively regulate triglycerides in the blood to help manage these potentially life-threatening common conditions.

Now, researchers at Baylor College of Medicine, Princeton University and Texas A&M University are closer to achieving this goal after discovering the 3D structure and mode of action of diacylglycerol O-acyltransferase-1 (DGAT1), the enzyme that synthesizes triglycerides and also is required for human dietary fat absorption and storage. DGAT1 is a known target to treat obesity and other metabolic diseases, so having a detailed understanding of what DGAT1 looks like and how it works opens opportunities for designing novel strategies for managing these conditions. The findings are published in the journal Nature.

“DGAT1 is a particularly interesting enzyme because it synthesizes triglycerides, which are the main component of hard fat, the type of fat usually found in the belly or midsection in our body. Triglycerides also are part of the particles that transport cholesterol—high-density lipoproteins (HDL, or ‘good cholesterol’), and low-density and very-low-density lipoproteins (LDL and VLDL, or ‘bad cholesterols’),” said co-corresponding author Dr. Ming Zhou, Ruth McLean Bowman Bowers Professor in Biochemistry in the Department of Biochemistry and Molecular Biology at Baylor. “Learning to regulate this enzyme can help regulate fat synthesis and potentially manage related conditions.”

The 42-year-old virologist and epidemiologist, who has responded to multiple outbreaks around the world, got sick about three days after a flight to his home in New Orleans.

“I had a mask on, I had gloves on, I did my normal wipes routine … but obviously, you can still get it through your eyes,” Fair said on the “TODAY” show from his hospital bed. “And of course I wasn’t wearing goggles on the flight.”

“That’s one of the three known routes of getting this infection that we just don’t pay a lot of attention to; we tend to pay attention to the nose and mouth because that is the most common route,” he said. “But you know, droplets landing on your eyes are just as infectious.”

Humanity has started off the new millennium with some astounding accomplishments.

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Continue reading “The 20 Biggest Tech Advances of the Past 20 Years” »

In a major blow to citizens’ privacy, the US Senate voted today to give law enforcement agencies such as the FBI and CIA the power to look into your browser history without a warrant. Thanks, Mitch McConnell.

Senators Ron Wyden from Oregan and Senator Steve Daines of Montana led the charge to insert privacy protections into the Patriot Act, which gives law enforcement agencies power for surveillance in order to maintain national security. However, the privacy protection amendment fell short by just one vote, as many senators who may have voted in favor of it didn’t show up.

Selmer Bringsjord (right): … Proving things. Discovering things. I don’t think that even a hair’s width of these things have been simulated in computational and cognitive science and in AI.

I remember asking James Moor, the Dartmouth professor who’s written quite a bit on AI: “You know. Jim, you really are a true believer in this stuff but can you tell me how much time you’re willing to give these AI people?”

Continue reading “Can Human Minds Be Reduced to Computer Programs?” »

A laser light shone through the dark could power robotic exploration of the most tantalising locations in our Solar System: the permanently-shadowed craters around the Moon’s poles, believed to be rich in water ice and other valuable materials.

ESA’s Discovery & Preparation programme funded the design of a laser system to keep a rover supplied with power from up to 15 km away while it explores some of these dark craters.

At the highest lunar latitudes, the Sun stays low on the horizon all year round, casting long shadows that keep sunken craters mired in permanent shadow, potentially on a timescale of billions of years. Data from NASA’s Lunar Reconnaissance Orbiter, India’s Chandrayaan-1 and ESA’s SMART-1 orbiters show these ‘permanently shadowed regions’ are rich in hydrogen, strongly suggesting water ice can be found there.

O,.,o.

The visitor from deep space has passed us by, but may be due for an outburst as it careens toward the sun.

This could essentially in the wrong hands be very bad but in the positive ways it could cure anything.

Right now the world is at war. But this is no ordinary war. It’s a fight with an organism so small we can only detect it through use of a microscope — and if we don’t stop it, it could kill millions of us in the next several decades. No, I’m not talking about COVID-19, though that organism is the one on everyone’s mind right now. I’m talking about antibiotic-resistant bacteria.

You see, more than 700,000 people died globally from bacterial infections last year — 35,000 of them in the U.S. If we do nothing, that number could grow to 10 million annually by 2050, according to a United Nations report.

Continue reading “YC startup Felix wants to replace antibiotics with programmable viruses” »

A group of tiny RNA that should attack the virus causing COVID-19 when it tries to infect the body are diminished with age and chronic health problems, a decrease that likely helps explain why older individuals and those with preexisting medical conditions are vulnerable populations, investigators report.

MicroRNAs play a big role in our body in controlling gene expression, and also are a front line when viruses invade, latching onto and cutting the RNA, the genetic material of the virus, says Dr. Sadanand Fulzele, aging researcher in the Department of Medicine and Center for Healthy Aging at the Medical College of Georgia at Augusta University.

But with age and some chronic medical conditions, the attacking microRNA numbers dwindle, reducing our ability to respond to viruses, says Dr. Carlos M. Isales, co-director of the MCG Center for Healthy Aging and chief of the MCG Division of Endocrinology, Diabetes and Metabolism.