Lifeboat Foundation

Two groups of nerve cells may serve as “on-off switches” for male mating and aggression, suggests a new study in rodents. These neurons appear to send signals between two parts of the brain—the back tip, or posterior, of the amygdala and the hypothalamus—that together regulate emotions including fear, anxiety, and aggression.

Led by researchers at NYU Grossman School of Medicine, the study showed that male mice struggled to have sex in experiments that blocked signals from one amygdala cell group that communicates with the hypothalamus (MPN-signaling cells). When the same signals were instead bolstered, the animals were not only able to mate but would repeatedly court unreceptive females, something they would not do normally.

Similarly, when the action of a second cell group in the amygdala that also communicates with the hypothalamus (VMHvl-signaling cells) was blocked, the rodents attacked unfamiliar males half as often. When these same neurons were triggered, the mice became unusually aggressive, even attacking their female mates and familiar males.

In the fight against pathogens, most researchers have focused on the diverse immune system arsenal that protects people against infection. However, the lab of Yale microbiologist Jorge Galan explored an evolutionarily ancient defense system possessed by every individual cell in the body.

In work published July 24th in the journal Science, Galan’s lab describes the role played by the mitochondria, the cell’s energy-producing organelle, in creating an anti-microbial compound capable of combatting Salmonella Typhi, the cause of typhoid fever. Using advanced imaging technology, Galan and colleagues show how the compound itaconate, produced in the mitochondria, can penetrate cellular defenses that protect the pathogen and disrupt its metabolism and ability to grow.

Bioprinting could be used for testing potential treatments for Covid-19, cancer and other diseases.

Bioprinting’s importance for pharmaceutical analysis is paramount now, not only for potential Covid-19 treatments, but also for testing treatments for cancer and other diseases. Dr. Atala says that the organoids allow researchers to analyze a drug’s impact on an organ “without the noise” of an individual’s metabolism.

He cited Rezulin, a popular diabetes drug recalled in 2000 after there was evidence of liver failure. His lab tested an archived version of the drug, and Dr. Atala said that within two weeks, the liver toxicity became apparent. What accounts for the difference? An organoid replicates an organ in its purest form and offers data points that might not occur in clinical trials, he said, adding that the testing is additive to, rather than in lieu of, clinical trials.

https://www.youtube.com/watch?v=1UDJB7DS1Lo&feature=youtu.be

Interviewed by mika curtis, for the space renaissance academy mentorship programme.

We are honored and proud to publish this interview with Prof. Paul Ziolo, Psychohistorian, Senior Lecturer at the University of Liverpool, who kindly accepted to reply to some questions about his role as a Mentor of the Space Renaissance Academy. https://youtu.be/1UDJB7DS1Lo

Continue reading “Paul Ziolo — interview” »

A study published today (July 27, 2020) in The Lancet Digital Health by UPMC and University of Pittsburgh researchers demonstrates the highest accuracy to date in recognizing and characterizing prostate cancer using an artificial intelligence (AI) program.

“Humans are good at recognizing anomalies, but they have their own biases or past experience,” said senior author Rajiv Dhir, M.D., M.B.A., chief pathologist and vice chair of pathology at UPMC Shadyside and professor of biomedical informatics at Pitt. “Machines are detached from the whole story. There’s definitely an element of standardizing care.”

To train the AI to recognize prostate cancer, Dhir and his colleagues provided images from more than a million parts of stained tissue slides taken from patient biopsies. Each image was labeled by expert pathologists to teach the AI how to discriminate between healthy and abnormal tissue. The algorithm was then tested on a separate set of 1,600 slides taken from 100 consecutive patients seen at UPMC for suspected prostate cancer.

Higher Steaks, a UK food technology start-up, has announced the world’s first cultivated bacon and pork belly.

As the world edges closer towards exascale computing, the University of Florida has announced a partnership with chipmaker NVIDIA that aims to create a 700-petaflop AI supercomputer next year.

A stunning flash of ultraviolet light from an exploding white dwarf has been detected by astronomers for only the second time, and could give researchers important clues about what spurs the demise of these ancient, spent stars.

Researchers became aware of this unusual supernova – called SN2019yvq – last December, only a day after the explosion took place. Within hours, scientists classified the event as a Type Ia supernova – not an unusual stellar event, ordinarily at least, except this time it was accompanied by the extremely rare flash of ultraviolet light.

“These are some of the most common explosions in the Universe,” says astrophysicist Adam Miller from Northwestern University.

In vitro activation (IVA) led to the birth of a healthy boy in Japan using a previously infertile woman’s own eggs.