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Aug 26, 2019

New details on Russia’s mysterious missile disaster suggest a nuclear reactor blew up

Posted by in category: nuclear energy

An explosion at a Russian weapons testing site in August released radioactive isotopes that almost certainly came from a nuclear reactor, experts say.

Aug 26, 2019

Global Study on Homicide

Posted by in categories: biotech/medical, sustainability

Homicide kills far more people than armed conflict, says new UNODC study

VIENNA/NEW YORK, 8 July (UN Information Service) – Some 464,000 people across the world were killed in homicides in 2017, surpassing by far the 89,000 killed in armed conflicts in the same period, according to the Global Study on Homicide 2019 published today by the United Nations Office on Drugs and Crime (UNODC).

“The Global Study on Homicide seeks to shed light on gender-related killings, lethal gang violence and other challenges, to support prevention and interventions to bring down homicide rates,” said UNODC Executive Director Yury Fedotov. “Countries have committed to targets under the Sustainable Development Goals to reduce all forms of violence and related death rates by 2030. This report offers important examples of effective community-based interventions that have helped to bring about improvements in areas afflicted by violence, gangs and organized crime.”

Aug 26, 2019

Designers Want to Give 3D Printers Legs, Let Them Wander the Earth

Posted by in category: 3D printing

Ever wonder what a 3D printer would look like if it could walk, fly, or swim?

Aug 26, 2019

Brazil’s president is actively trying to devastate the Amazon rainforest, leaked documents show

Posted by in category: government

Brazil’s government plans to build bridge, motorway and hydroelectric plant through world’s largest jungle.

Aug 26, 2019

Mexico Reports Highest Ever Homicide Rate In 2018, Tops 33,000 Investigations

Posted by in category: futurism

Forensic personnel load the corpse of a man into a van, after he was executed at a shopping mall in Acapulco, Mexico, on April 24, 2018. A new report recorded more than 33,000 homicides in 2018, making it the country’s deadliest on record. Francisco Robles/AFP/Getty Images hide caption.

Aug 26, 2019

A Multidimensional Systems Biology Analysis of Cellular Senescence in Ageing and Disease

Posted by in categories: biotech/medical, life extension

Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of ageing and has been linked to ageing-related diseases like cancer. Senescent cells have been shown to accumulate in tissues of aged organisms which in turn can lead to chronic inflammation. Many genes have been associated with cell senescence, yet a comprehensive understanding of cell senescence pathways is still lacking. To this end, we created CellAge (, a manually curated database of 279 human genes associated with cellular senescence, and performed various integrative and functional analyses. We observed that genes promoting cell senescence tend to be overexpressed with age in human tissues and are also significantly overrepresented in anti-longevity and tumour-suppressor gene databases. By contrast, genes inhibiting cell senescence overlapped with pro-longevity genes and oncogenes. Furthermore, an evolutionary analysis revealed a strong conservation of senescence-associated genes in mammals, but not in invertebrates. Using the CellAge genes as seed nodes, we also built protein-protein interaction and co-expression networks. Clusters in the networks were enriched for cell cycle and immunological processes. Network topological parameters also revealed novel potential senescence-associated regulators. We then used siRNAs and observed that of 26 candidates tested, 19 induced markers of senescence. Overall, our work provides a new resource for researchers to study cell senescence and our systems biology analyses provide new insights and novel genes regarding cell senescence.

Aug 26, 2019

After Her Years of Research, a Cambridge Scientist Could Be on the Verge of Curing Multiple Sclerosis

Posted by in category: biotech/medical

Not only has Su Metcalfe’s treatment succeeded in early trials, it involves zero drugs and no side effects—and it could begin human trials as soon as 2020.

Aug 26, 2019

Neuroscientist Says Brain Uploads Are Bunk

Posted by in category: neuroscience

Any thoughts?

What the nervous system of the roundworm tells us about freezing brains and reanimating human minds.

Aug 26, 2019

Saving Senegal’s mangroves

Posted by in category: sustainability

Haidar el Ali’s reforestation project has planted 152 million mangrove buds in southern Senegal over the past decade!

BBC News Africa

Aug 26, 2019

Judge rules against Johnson & Johnson in landmark opioid case in Oklahoma

Posted by in categories: biotech/medical, law

Oklahoma Attorney General Mike Hunter had claimed that J&J and its pharmaceutical subsidiary Janssen aggressively marketed to doctors and downplayed the risks of opioids as early as the 1990s. The state said J&J’s sales practices created an oversupply of the addictive painkillers and “a public nuisance” that upended lives and would cost the state $12.7 billion to $17.5 billion. The state was seeking more than $17 billion from the company.

J&J, which marketed the opioid painkillers Duragesic and Nucynta, has denied any wrongdoing. Lawyers for the company disputed the legal basis Oklahoma used to sue J&J, relying on a “public nuisance” claim. They said the state has previously limited the act to disputes involving property or public spaces.

Investors were expecting J&J to be fined between $500 million and $5 billion, according to Evercore ISI analyst Elizabeth Anderson.