Lifeboat Foundation

Three-dimensional (3D), submillimeter-scale constructs of neural cells, known as cortical spheroids, are of rapidly growing importance in biological research because these systems reproduce complex features of the brain in vitro. Despite their great potential for studies of neurodevelopment and neurological disease modeling, 3D living objects cannot be studied easily using conventional approaches to neuromodulation, sensing, and manipulation. Here, we introduce classes of microfabricated 3D frameworks as compliant, multifunctional neural interfaces to spheroids and to assembloids. Electrical, optical, chemical, and thermal interfaces to cortical spheroids demonstrate some of the capabilities. Complex architectures and high-resolution features highlight the design versatility. Detailed studies of the spreading of coordinated bursting events across the surface of an isolated cortical spheroid and of the cascade of processes associated with formation and regrowth of bridging tissues across a pair of such spheroids represent two of the many opportunities in basic neuroscience research enabled by these platforms.

Progress in elucidating the development of the human brain increasingly relies on the use of biosystems produced by three-dimensional (3D) neural cultures, in the form of cortical spheroids, organoids, and assembloids (1–3). Precisely monitoring the physiological properties of these and other types of 3D biosystems, especially their electrophysiological behaviors, promises to enhance our understanding of the interactions associated with development of the nervous system, as well as the evolution and origins of aberrant behaviors and disease states (4–8). Conventional multielectrode array (MEA) technologies exist only in rigid, planar, and 2D formats, thereby limiting their functional interfaces to small areas of 3D cultures, typically confined to regions near the bottom contacting surfaces.

Importance Numerous prognostic models of suicide risk have been published, but few have been implemented outside of integrated managed care systems.

Objective To evaluate performance of a suicide attempt risk prediction model implemented in a vendor-supplied electronic health record to predict subsequent suicidal ideation and suicide attempt.

Design, Setting, and Participants This observational cohort study evaluated implementation of a suicide attempt prediction model in live clinical systems without alerting. The cohort comprised patients seen for any reason in adult inpatient, emergency department, and ambulatory surgery settings at an academic medical center in the mid-South from June 2019 to April 2020.

From microwave ovens to Wi-Fi connections, the radio waves that permeate the environment are not just signals of energy consumed but are also sources of energy themselves. An international team of researchers, led by Huanyu “Larry” Cheng, Dorothy Quiggle Career Development Professor in the Penn State Department of Engineering Science and Mechanics, has developed a way to harvest energy from radio waves to power wearable devices.

The researchers recently published their method in Materials Today Physics.

According to Cheng, current energy sources for wearable health-monitoring devices have their place in powering sensor devices, but each has its setbacks. Solar power, for example, can only harvest energy when exposed to the sun. A self-powered triboelectric device can only harvest energy when the body is in motion.

Researchers at the Georgia Institute of Technology have uncovered an innovative way to tap into the over-capacity of 5G networks, turning them into “a wireless power grid” for powering Internet of Things (IoT) devices that today need batteries to operate.

The Georgia Tech inventors have developed a flexible Rotman lens-based rectifying antenna (rectenna) system capable, for the first time, of millimeter-wave harvesting in the 28-GHz band. (The Rotman lens is key for beamforming networks and is frequently used in radar surveillance systems to see targets in multiple directions without physically moving the antenna system.)

But to harvest enough power to supply low-power devices at long ranges, large aperture antennas are required. The problem with large antennas is they have a narrowing field of view. This limitation prevents their operation if the antenna is widely dispersed from a 5G base station.

Bright semiconductor nanocrystals known as quantum dots give QLED TV screens their vibrant colors. But attempts to increase the intensity of that light generate heat instead, reducing the dots’ light-producing efficiency.

A new study explains why, and the results have broad implications for developing future quantum and photonics technologies where light replaces electrons in computers and fluids in refrigerators, for example.

In a QLED TV screen, dots absorb blue light and turn it into green or red. At the low energies where TV screens operate, this conversion of light from one color to another is virtually 100% efficient. But at the higher excitation energies required for brighter screens and other technologies, the efficiency drops off sharply. Researchers had theories about why this happens, but no one had ever observed it at the atomic scale until now.

She confirmed dark matter, probed spiral galaxies and fought inequality.

LONDON (AP) — The rainbow flag flew proudly Thursday above the Bank of England in the heart of London’s financial district to commemorate World War II codebreaker Alan Turing, the new face of Britain’s 50-pound note.

The design of the bank note was unveiled before it is being formally issued to the public on June 23, Turing’s birthday. The 50-pound note is the most valuable denomination in circulation but is little used during everyday transactions, especially during the coronavirus pandemic as digital payments increasingly replaced the use of cash.

The new note, which is laden with high-level security features and is made of longer-lasting polymer, completes the bank’s rejig of its paper currencies over the past few years. Turing’s image joins that of Winston Churchill on the five-pound note, novelist Jane Austen on the 10-pound note and artist J. M. W. Turner on the 20-pound note.

“Genius Makers” and “Futureproof,” both by experienced technology reporters now at The New York Times, are part of a rapidly growing literature attempting to make sense of the A.I. hurricane we are living through. These are very different kinds of books — Cade Metz’s is mainly reportorial, about how we got here; Kevin Roose’s is a casual-toned but carefully constructed set of guidelines about where individuals and societies should go next. But each valuably suggests a framework for the right questions to ask now about A.I. and its use.

Two new books — “Genius Makers,” by Cade Metz, and “Futureproof,” by Kevin Roose — examine how artificial intelligence will change humanity.

Space communications and navigation engineers at NASA are evaluating the navigation needs for the Artemis program, including identifying the precision navigation capabilities needed to establish the first sustained presence on the lunar surface.