Lifeboat Foundation

It’s long been assumed that as cells divide in the human body, the genome is faithfully replicated in the resulting daughter cells. While errors are known to arise, there is machinery in the cell that can detect these genetic errors, and can often repair them. When mutations remain in the genome, it raises the risk that disease will arise.

But the human genome is made up of about 6 billion bases, and the human body contains billions, even trillions of cells. And it seems that errors and variations in the genome could actually arise far more often than we knew, according to a new study reported in Nature Genetics that analyzed blood stem cells. The research used advanced sequencing techniques to show that humans are made up of cells whose genomes may be far more heterogeneous that assumed. And these variations between cells are not always small. The research determined that about one out of every forty blood stem cells in healthy people carry major chromosomal alterations in their DNA. These chromosomal changes included copy number variations and rearrangements, but did not seem to cause any deleterious effect.

Fewer miniature black holes found:

Researchers at the University of Tokyo have found that the universe contains far fewer miniature black holes than previously thought, potentially shaking up current theories about dark matter.

Using advanced quantum field theory, typically reserved for subatomic particles, they applied this understanding to the early universe. They discovered new insights into primordial black holes (PBHs), which have been a strong contender for dark matter. Upcoming observations could soon confirm their surprising findings.

Awkward.

“The prevalence and harms of online misinformation is a perennial concern for internet platforms, institutions and society at large,” reads the paper. “The rise of generative AI-based tools, which provide widely-accessible methods for synthesizing realistic audio, images, video and human-like text, have amplified these concerns.”

The study, first caught by former Googler Alexios Mantzarlis and flagged in the newsletter Faked Up, focused on media-based misinformation, or bad information propagated through visual mediums like images and videos. To narrow the scope of the research, the study focused on media that was fact-checked by the service ClaimReview, ultimately examining a total of 135,838 fact-check-tagged pieces of online media.

Continue reading “Even Google’s Own Researchers Admit AI Is Top Source of Misinformation Online” »

People battling advanced colon cancers might have a new treatment option that could extend their survival, a new trial finds.

A combination of two experimental immunotherapy drugs plus standard chemotherapy led to a median 19.7 month survival for patients, compared to the median 9.5 months observed among folks who only got a targeted therapy called regorafenib.

“These results pave the way for further exploration of this promising treatment approach,” said study first author Dr. Zev Wainberg. He co-directs the UCLA Health GI Oncology Program, and is a researcher at the UCLA Health Jonsson Comprehensive Cancer Center.

Do you worry that you’ll get to the end of a good list and have nothing more, leaving you sad and starved of data? Worry no more! — ianb/infinite-ai-array.

Oncologists base prognosis, the predicted long-term outcome of an individual’s cancer, on the chances of recovery versus the chances of experiencing a recurrence or failure to respond to interventions. A clear understanding of prognosis can significantly influence treatment planning, lifestyle, and overall quality of life of a cancer patient. Thus, ongoing research to uncover, validate, and optimize the predictive accuracy of prognostic factors, modifiable or non-modifiable characteristics that help estimate prognosis, has significant value to areas of cancer treatment and care.

A meta-analysis recently published in the International Journal of Gynecological Cancer evaluated the value of different prognostic factors for epithelial ovarian cancer, an aggressive and deadly cancer occurring in the tissue lining women’s ovaries.

Epithelial ovarian cancer represents a highly fatal disease, with an estimated 19,680 new cases and 12,740 deaths in the United States in 2024. Diagnosis of ovarian cancer remains challenging, and as a result, most women with ovarian cancer have advanced-stage disease. Once advanced, ovarian cancer may spread into the peritoneum, the tissue lining the abdominal wall and pelvic cavity, making it difficult to identify small lesions and fully assess the condition.

Want to go on an unforgettable trip? Abstract Submission closing soon! Exciting news from SnT, Interdisciplinary Centre for Security, Reliability and Trust, University of Luxembourg! We are thrilled to announce the 1st European Interstellar Symposium in collaboration with esteemed partners like the Interstellar Research Group, Initiative & Institute for Interstellar Studies, Breakthrough Prize Foundation, and Luxembourg Space Agency. This interdisciplinary symposium will delve into the profound questions surrounding interstellar travel, exploring topics such as human and robotic exploration, propulsion, exoplanet research, life support systems, and ethics. Join us to discuss how these insights will impact near-term applications on Earth and in space, covering technologies like optical communications, ultra-lightweight materials, and artificial intelligence. Don’t miss this opportunity to connect with a community of experts and enthusiasts, all united in a common goal. Check out the “Call for Papers” link in the comment section to secure your spot! Image credit: Maciej Rębisz, Science Now Studio #interstellar #conference #Luxembourg #exoplanet

From Google, Johns Hopskins, & Oxford LLMs achieve adult human performance on higher-order theory of mind tasks.

From google, johns hopskins, & oxford.

LLMs achieve adult human performance on higher-order theory of mind tasks https://huggingface.co/papers/2405.

Continue reading “Paper page — LLMs achieve adult human performance on higher-order theory of mind tasks” »

1947 was an interesting year. Not that I was there myself, you understand, but I’ve heard stories. For example, 1947 was the year the Hungarian-British electrical engineer and physicist Dennis Gabor invented holography. 1947 was also the year William Shockley, John Bardeen, and Walter Brattain demonstrated the first transistor at Bell Labs. Also in 1947, Alan Turing gave what the Encyclopedia Britannica describes as “Quite possibly the earliest public lecture to mention computer intelligence.” Now, a mere 77 years later, these three fields are coming together in awesome ways.