Lifeboat Foundation

Imagine one drug that can target and kill malignant cells for some patients with many types of cancer. A new drug called Vitrakvi (larotrectinib), now approved by the U.S. Food and Drug Administration, shows promise of doing just that for both adults and children with a variety of sometimes rare cancers that share one specific genetic mutation.

The mutation, called a TRK fusion, occurs when one of three NTRK genes becomes mistakenly connected to an unrelated gene and ignites uncontrolled growth. By solely targeting this mutation, the drug is designed to turn off growth signaling with a minimum of other toxicities.

According to the drug manufacturer, Loxo Oncology, this specific mutation can occur in a small subset of various adult and pediatric solid tumors ranging from cancers of the appendix, bile ducts, breast, lung, pancreas and thyroid to melanoma, GIST and various sarcomas.

Continue reading “FDA Approves Drug That Targets Key Genetic Driver of Cancer” »

A number of different things have to happen for a child to develop leukemia.

The idea of a cancer vaccine is something researchers have been working on for over 50 years, but until recently they were never able to prove exactly how such a vaccine would work.

Now, a team of researchers at the Institute for Research in Immunology and Cancer (IRIC) at Université de Montréal has demonstrated that a vaccine can work. Not only that, it could become an extremely effective, non-invasive and cost-effective cancer-fighting tool.

The team’s work was published yesterday in Science Translational Medicine.

Continue reading “Major breakthrough in quest for cancer vaccine” »

By 2020, China plans to assign each of its 1.4 billion citizens a “social credit score” that will determine what people are allowed to do, and where they rank in society.

It’s part of a broad effort in China to build a so-called reputation system that will measure, in theory, the credibility of government officials and businesses, in addition to citizens. The Chinese government says the system will boost “trust” nationwide and build a culture of “sincerity.”

Continue reading “How China’s ‘social credit score’ will punish and reward citizens” »

Antibiotics have emerged as potentially lifespan-enhancing drugs, according to the results of new research carried out in the UK.

Genetic experiments that eliminate “senescent” cells – older cells, which lose the ability to divide – have already been proven to alleviate age-related dysfunction in model organisms.

Now, scientists have shown for the first time that an FDA-approved antibiotic – Azithromycin – can effectively target and eliminate senescent cells in culture.

Continue reading “Antibiotics eliminate senescent cells associated with ageing” »

Amazon is offering more than 30 courses as well as a certification exam.

The gap between the life expectancy of the richest and poorest sectors of society in England is increasing, according to new research from Imperial College London.

The research, published in the journal Lancet Public Health, also reveals that the life expectancy of England’s poorest women has fallen since 2011, in what researchers say is a “deeply worrying” trend.

The study, funded by the Wellcome Trust, analysed Office for National Statistics data on all deaths recorded in England between 2001 and 2016—7.65 million deaths in total.

Continue reading “Poorest dying nearly 10 years younger than the rich in ‘deeply worrying’ trend for UK” »

EXPLORER, the world’s first medical imaging scanner that can capture a 3D picture of the whole human body at once, has produced its first scans.

The brainchild of UC Davis scientists Simon Cherry and Ramsey Badawi, EXPLORER is a combined positron emission tomography (PET) and X-ray computed tomography (CT) scanner that can image the entire body at the same time. Because the machine captures radiation far more efficiently than other scanners, EXPLORER can produce an image in as little as one second and, over time, produce movies that can track specially tagged drugs as they move around the entire body.

Continue reading “Human images from world’s first total-body scanner unveiled” »

A French physicist has won an Ig Nobel Prize for using mathematical formulas to determine whether cats are liquid or solid.

Continue reading “Physicist Wins Ig Noble Prize For Study On Whether Cats Should Be Classified As Liquids Or Solids” »