Lifeboat Foundation

Keytruda actually treats 16 types of cancer.

Learn about how KEYTRUDA® (pembrolizumab) works as an immunotherapy to help fight certain cancers.

The volar aircraft has a sleek, aerodynamic form that’s more akin to a supercar than other eVTOLs currently in development.

Over the last several decades, I’ve witnessed a lot of change in the fields of machine learning (ML) and computer science. Early approaches, which often fell short, eventually gave rise to modern approaches that have been very successful. Following that long-arc pattern of progress, I think we’ll see a number of exciting advances over the next several years, advances that will ultimately benefit the lives of billions of people with greater impact than ever before. In this post, I’ll highlight five areas where ML is poised to have such impact. For each, I’ll discuss related research (mostly from 2021) and the directions and progress we’ll likely see in the next few years.

Although multimorbidity differs for each person, we know that patients tend to suffer from the same groups of diseases — known as “clusters”. This suggests that each cluster may share a common underlying cause. For example, a person with multimorbidity may suffer from heart problems (such as heart disease and high blood pressure) and diabetes, which may all stem from the same cause — such as obesity.

Identifying and treating the cause of a patient’s disease clusters would allow us to more effectively combat several — or even all — of the diseases a patient has using a single treatment. This would both reduce the number of medical appointments a person needs to attend and the number of medications they may need to take.

Ageing is the single biggest risk factor for developing multimorbidity.

Continue reading “Tackling ageing may be best way to prevent multiple chronic conditions from developing in older people” »

Next Fiat Panda aims for ‘most affordable EV’ title with customizable, clever crossover that will slot below 500e.

What’s the most affordable EV you can buy? If rumors out of Fiat are to be believed, the answer to that question will soon be “the new Fiat Panda” as Stellantis targets the bottom end of the booming electric car market.

Set to arrive as soon as this spring, the new Fiat Panda will be an EV-only offering from Stellantis’ “entry” Italian brand, and is expected to slot in below the ell-electric Fiat 500e, price-wise, in the company’s lineup. Its main objective, as the brand’s President, Oliver Francois, told AutoExpress UK, is to “awaken the sleeping giant” he believes Fiat to be. “That’s exactly my point of view,” he says, when discussing new models. “We have not even started awakening the giant.”

Continue reading “Next Fiat Panda aims for ‘most affordable EV’ title, will slot below 500e” »

The idea that our genes are our fate” is dead. Exciting new discoveries in the field of epigenetics have proven that our lifestyle and environment can turn off and on many of the genes that control our health and wellbeing. Simple things like where we live, what we eat, pollution, stress, and exercise all impact which genes are silenced and expressed throughout our lives.

Research has shown that that the current dramatic rise in obesity, heart disease, diabetes and Alzheimer’s all have epigenetic mechanisms at play. Not only that but many epigenetic changes are actually passed to future generations: your grandmother’s dietary deficits may have caused your diabetes. Your father’s smoking may have turned on your marker for obesity or ADHD. Three generations later the descendants of holocaust survivors are still suffering stress disorders.

Continue reading “Why Are We Genetically Modifying Humans? | Epigenetics | Spark” »

Like so much in chronic disease, Alzheimer’s is complicated: “once you have seen one person with Alzheimer’s, you have seen one person with Alzheimer’s. In other words, Alzheimer’s disease (AD) is a heterogeneous disease which may present and progress differently depending on the person and the factors contributing to the disease pathology. As such, there is no paint-by-numbers approach to targeted treatment. Researchers in the field are thus motivated to figure out a way to categorize AD in order to guide more individualized approaches to patient care and help anticipate disease trajectory.”

A proposal for 4 subtypes of Alzheimer’s disease.

The mysterious dimming of a famous, bright star may have been solved.

Betelgeuse has intrigued astronomers with its “Great Dimming,” but the most famous star in Orion may have generated the event in a massive cosmic burp.

Universal law always works perfectly well.

Wherever there is sand and an atmosphere, prevailing winds may whip the grains into undulating shapes, pleasing to the eye with their calming repetition.

Certain sand waves, with wavelengths between 30 centimeters (almost 12 inches) and several meters (around 30 feet), are known as megaripples: they’re between ordinary beach ripples and full dunes in size, and we’ve seen them not just on Earth, but even on other planets such as Mars, well known for its all-encompassing dust storms.

Continue reading “There’s a Hidden Mathematical ‘Law’ in The Sand Megaripples Found All Over Earth” »