Lifeboat Foundation

In recent years, ribonucleic acid (RNA) has emerged as a powerful tool for the development of novel therapies. RNA is used to copy genetic information contained in our hereditary material, the deoxyribonucleic acid (DNA), and then serves as a template for building proteins, the building blocks of life. Delivery of RNA into cells remains a major challenge for the development of novel therapies across a broad range of diseases. Researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden together with researchers from the global biopharmaceutical company AstraZeneca have investigated where and how mRNA is delivered inside the cell. They found that mRNA uses an unexpected entry door. Their results provide novel insights into the development of RNA therapeutics towards efficient delivery and lower dosages.

DNA (deoxyribonucleic acid) contains the genetic information required for the development and maintenance of life. This information is communicated by messenger ribonucleic acid (mRNA) to make proteins. mRNA-based therapeutics have the potential to address unmet needs for a wide variety of diseases, including cancer and cardiovascular disease. mRNA can be delivered to cells to trigger the production, degradation or modification of a target protein, something impossible with other approaches. A key challenge with this modality is being able to deliver the mRNA inside the cell so that it can be translated to make a protein. mRNA can be packed into lipid nanoparticles (LNPs)—small bubbles of fat—that protect the mRNA and shuttle it into cells. However, this process is not simple, because the mRNA has to pass the membrane before it can reach its site of action in the cell interior, the cytoplasm.

Researchers in the team of MPI-CBG director Marino Zerial are experts in visualizing the cellular entry routes of molecules in the cell, such as mRNA with high-resolution microscopes. They teamed up with scientists from AstraZeneca who provided the researchers with lipid nanoparticle prototypes that they had developed for therapeutic approaches to follow the mRNA inside the cell. The study is published in the Journal of Cell Biology.

Nanoengineers at the University of California San Diego have developed a new and potentially more effective way to deliver messenger RNA (mRNA) into cells. Their approach involves packing mRNA inside nanoparticles that mimic the flu virus—a naturally efficient vehicle for delivering genetic material such as RNA inside cells.

The new mRNA delivery nanoparticles are described in a paper published recently in the journal Angewandte Chemie International Edition.

The work addresses a major challenge in the field of drug delivery: Getting large biological drug molecules safely into cells and protecting them from organelles called endosomes. These tiny acid-filled bubbles inside the cell serve as barriers that trap and digest large molecules that try to enter. In order for biological therapeutics to do their job once they are inside the cell, they need a way to escape the endosomes.

An international research team led by the University of Göttingen has detected novel quantum effects in high-precision studies of natural double-layer graphene and has interpreted them together with the University of Texas at Dallas using their theoretical work. This research provides new insights into the interaction of the charge carriers and the different phases, and contributes to the understanding of the processes involved. The LMU in Munich and the National Institute for Materials Science in Tsukuba, Japan, were also involved in the research. The results were published in Nature.

The novel material graphene, a wafer-thin layer of carbon atoms, was first discovered by a British research team in 2004. Among other unusual properties, graphene is known for its extraordinarily high electrical conductivity. If two individual graphene layers are twisted at a very specific angle to each other, the system even becomes superconducting (i.e. conducts electricity without any resistance) and exhibits other exciting quantum effects such as magnetism. However, the production of such twisted graphene double-layers has so far required increased technical effort.

This novel study used the naturally occurring form of double-layer graphene, where no complex fabrication is required. In a first step, the sample is isolated from a piece of graphite in the laboratory using a simple adhesive tape. To observe quantum mechanical effects, the Göttingen team then applied a high electric field perpendicular to the sample: the electronic structure of the system changes and a strong accumulation of charge carriers with similar energy occurs.

A sheet of magic-angle twisted bilayer graphene can host novel topological phases of matter, a study has revealed.

Magic-angle twisted graphene, first discovered in 2018, is made from two sheets of graphene (a form of carbon consisting of a single layer of atoms in a honeycomb-like lattice pattern), layered atop one another, with one sheet twisted at precisely 1.05 degrees with respect to the other. The resulting bilayer has unusual electronic properties: for example, it can be made into an insulator or a superconductor depending on how many electrons are added.

The discovery launched a new field of research into magic-angle twisted graphene, known as “twistronics.” At Caltech, Stevan Nadj-Perge, assistant professor of applied physics and materials science, has been among the researchers leading the charge: in 2019, he and his colleagues directly imaged the electronic properties of magic-angle twisted graphene at atomic-length scales; and in 2020, they demonstrated that superconductivity in twisted bilayer graphene can exist away from the magic angle when coupled to a two-dimensional semiconductor.

Electrons inhabit a strange and topsy-turvy world. These infinitesimally small particles have never ceased to amaze and mystify despite the more than a century that scientists have studied them. Now, in an even more amazing twist, physicists have discovered that, under certain conditions, interacting electrons can create what are called ‘topological quantum states.’ This finding, which was recently published in the journal Nature, has implications for many technological fields of study, especially information technology.

Topological states of matter are particularly intriguing classes of quantum phenomena. Their study combines quantum physics with topology, which is the branch of theoretical mathematics that studies geometric properties that can be deformed but not intrinsically changed. Topological quantum states first came to the public’s attention in 2016 when three scientists—Princeton’s Duncan Haldane, who is Princeton’s Thomas D. Jones Professor of Mathematical Physics and Sherman Fairchild University Professor of Physics, together with David Thouless and Michael Kosterlitz—were awarded the Nobel Prize for their work in uncovering the role of topology in electronic materials.

“The last decade has seen quite a lot of excitement about new topological quantum states of electrons,” said Ali Yazdani, the Class of 1909 Professor of Physics at Princeton and the senior author of the study. “Most of what we have uncovered in the last decade has been focused on how electrons get these topological properties, without thinking about them interacting with one another.”

Assembling Lego-like, 2D heterostructures can give rise to emergent properties and functionalities very different from the intrinsic characteristics of the constituents.

Density functional theory (DFT)-based band-structure calculations can shed light on interfacial properties of different heterostructures.

South Korea’s Moon mission

The mission will circle the Moon for about a year at about 100 kilometers above the surface, searching for possible landing sites for future missions, conducting scientific research on the lunar environment, and testing space internet technology, South Korea’s Ministry of Science and ICT said in a statement. This mission will help prepare the country’s small space program for future exploration, as they hope to send a lander to the Moon by 2030.

Continue reading “South Korea just launched a rocket to orbit the Moon, a first for the country” »

Skin healing processes and spacewalk preparations filled the work schedule aboard the International Space Station on Friday. The Expedition 67 crew members are also readying a U.S. space freighter for its return to Earth next week.

Four astronauts aboard the orbiting lab practiced surgical techniques to heal wounds in microgravity on Friday in the Kibo laboratory module. The quartet split up in groups of two with NASA astronaut Bob Hines joining ESA (European Space Agency) Flight Engineer Samantha Cristoforetti for the first practice session during the morning. In the afternoon, NASA Flight Engineers Kjell Lindgren and Jessica Watkins began their session studying how to take biopsies and suture wounds inside the Life Science Glovebox.

During the middle of the day, the foursome had time set aside time for gathering frozen research samples inside science freezers and preparing them for departure back to Earth inside the SpaceX Dragon resupply ship. Dragon is due to leave the station on Aug. 18 loaded with over 4,000 pounds of station supplies and science experiments after 33 days docked to the Harmony module’s forward port. The commercial cargo craft will parachute to a splashdown off the coast of Florida the next day for retrieval by NASA and SpaceX personnel.

Sustained space exploration will require infrastructure that doesn’t currently exist: buildings, housing, rocket landing pads.

So, where do you turn for construction materials when they are too big to fit in your carry-on and there’s no Home Depot in outer space?

“If we’re going to live and work on another planet like Mars or the moon, we need to make concrete. But we can’t take bags of concrete with us—we need to use local resources,” said Norman Wagner, Unidel Robert L. Pigford Chair of Chemical and Biomolecular Engineering at the University of Delaware.