Sep 26, 2024
Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging
Posted by Cecile G. Tamura in category: life extension
Partial reprogramming with the Yamanaka transcription factors is considered to be a potential anti-aging strategy, but until now largely regarded as systemic intervention.
Reprogramming aged cells through targeted overexpression of Oct4, Sox2, and Klf4 leads to beneficial health effects in progeroid and aged mice.