Lifeboat Foundation

Aging is known to have profound effects on the human brain, prompting changes in the composition of cells and the expression of genes, while also altering aspects of the interaction between genes and environmental factors. While past neuroscience studies have pinpointed many of the molecular changes associated with aging, the age-related genetic factors influencing specific neuron populations remains poorly understood.

Recent studies on flies, mice, primates and human brain tissue utilizing single-cell or single-nucleus RNA-sequencing and genetic experimental techniques shed new light on these cell-type-specific changes. For instance, they unveiled the effects of aging on glial cells in the mouse and human brain, associations between cell-specific changes and modified chromatin proteins, and the influence of DNA methylation in the aging of various tissues.

Researchers at University of California (UC) San Diego and Salk Institute recently carried out a study aimed at better understanding how both age and sex impact human cortical neurons at a single-cell level. Their findings, published in Neuron, offer new insights into how aging affects cell composition, gene expression and DNA methylation across human brain cell types, while also uncovering differences between gene expression and DNA methylation in females and males.

Candle flames and airplane engines produce tiny soot particles from polycyclic aromatic hydrocarbons (PAHs) as their precursors, both of which are harmful to humans and the environment. These carbon-based particles are also common in space, making up 10–12% of interstellar matter, and are becoming valuable for use in electronic devices and sustainable energy. However, the fingerprint signals of soot and PAHs have very short lifespans in flames—lasting only a few billionths to millionths of a second. This brief existence requires very fast cameras to capture their behavior in both space and time.

Astronomers from the Special Astrophysical Observatory (SAO) in Russia and elsewhere report the discovery of a new cataclysmic variable system, designated SRGe J194401.8+284452, which is located some 1,350 light years away. The finding was detailed in a research paper published August 26 on the pre-print server arXiv.

The world’s most powerful supercomputer is helping resolve conflicting research results that have puzzled scientists for more than a decade, which could also shine new light inside collapsing stars.

Mimicking animals is a proven strategy in robot design. Take, for example, Haibo Dong’s seminal studies on how fins propel fish by churning the water in a vortex.

Researchers from Skoltech, Universitat Politècnica de València, Institute of Spectroscopy of RAS, University of Warsaw, and University of Iceland have demonstrated the spontaneous formation and synchronization of multiple quantum vortices in optically excited semiconductor microcavities.

Upon ultrafast photoexcitation, an all-dielectric nonlocal metasurface enables giant dichroism and birefringence modulations, working as a quarter-waveplate actively reconfigurable over picoseconds.

Thousands of light particles can merge into a type of “super photon” under certain conditions. Researchers at the University of Bonn have now been able to use “tiny nano molds” to influence the design of this so-called Bose-Einstein condensate. This enables them to shape the speck of light into a simple lattice structure consisting of four points of light arranged in quadratic form. Such structures could potentially be used in the future to make the exchange of information between multiple participants tap-proof.

The results have now been published in the journal Physical Review Letters (“Bose-Einstein Condensation of Photons in a Four-Site Quantum Ring”).

By creating indents on the reflective surfaces (shown on the left in an exaggerated form; the reflective surfaceis facing upwards), the researchers were able to imprint a structure ontothe photon condensate (right). (Image: IAP, Universität Bonn)

Advances in generative AI mean fake images, videos, audio and bots are now everywhere. But studies have revealed the best ways to tell if something is real.

By Jeremy Hsu