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Huntington’s disease (HD) is a neurological disorder that causes progressive loss of movement, coordination and cognitive function. It is caused by a mutation in a single gene called huntingtin (HTT). More than 200,000 people worldwide live with the genetic condition, approximately 30,000 in the United States. More than a quarter of a million Americans are at risk of inheriting HD from an affected parent. There is no cure.

But in a new study, published December 12, 2022 in Nature Neuroscience, researchers at University of California San Diego School of Medicine, with colleagues elsewhere, describe using RNA-targeting CRISPR/Cas13D technology to develop a new therapeutic strategy that specifically eliminates toxic RNA that causes HD.

CRISPR is known as a genome-editing tool that allows scientists to add, remove or alter genetic material at specific locations in the genome. It is based on a naturally occurring immune defense system used by bacteria. However, current strategies run the risk of off-target edits at unintended sites that may cause permanent and inheritable chromosomal insertions or genome alterations. Because of this, significant efforts have focused on identifying CRISPR systems that target RNA directly without altering the genome.

An international research team led by Dr. Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior of the cell.

Patients with mutations in this protein suffer from Allan-Herndon-Dudley syndrome, a rare disease that takes the form of serious neurological alterations, in which each patient may reveal a different mutation of MCT8.

This study, published in Neurobiology of Disease, describes the first avatar model for the disease—in other words, the first animal model with the same genetic alteration as various patients.

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Germany says China is operating two illegal ‘police stations’ on its territory. These set-ups don’t have a fixed office, and are run by private individuals from the Chinese diaspora. The aim is to collect information on Chinese dissidents and citizens in exile and pass that on to Beijing.
Its a pattern that’s come to light across the world. An earlier report by Madrid based NGO Safeguard Defenders claimed there were more than a hundred such ‘police stations’ in at least 53 countries. Most exist illegally and aim to monitor, coerce and in some instances repatriate, those Beijing considers criminal or anti-China.

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Continue reading “How China operates illegal ‘police stations’ in foreign countries | DW News” »

Ispace Inc. is a private Japanese company developing robotic landers and rovers for missions to the Moon. It aims to compete for both transportation and exploration mission contracts from space agencies and private industry. If successful, these spacecraft and the accompanying vehicles could enable clients to discover, map, and use the natural resources on Earth’s nearest neighbour.

In addition to its headquarters in Tokyo, the company has offices in the United States and Luxembourg, employing around 200 people. Although founded in 2010, its team of engineers had earlier competed in the Google Lunar X Prize.

Following more than a decade of research and development, ispace yesterday launched Hakuto-R Mission 1 – delivered into space on a partially reusable Falcon 9 Block 5 rocket. The spacecraft will now perform orbital manoeuvres, taking it as far as 1.5 million km (932,000 miles) from Earth, before arriving at the Moon sometime in April 2023.

Summary: Researchers engineered cells containing customized adhesion molecules that bind to specific cell partners in predictable ways to form complex multicellular entities. The discovery is a major step toward building new tissue and organs.

Source: UCSF

Researchers at UC San Francisco (UCSF) have engineered molecules that act like “cellular glue,” allowing them to direct in precise fashion how cells bond with each other. The discovery represents a major step toward building tissues and organs, a long-sought goal of regenerative medicine.

Christopher Nolan revealed to Total Film magazine that he recreated the first nuclear weapon detonation without CGI effects as part of the production for his new movie “Oppenehimer.” The film stars longtime Nolan collaborator Cillian Murphy as J. Robert Oppenheimer, a leading figure of the Manhattan Project and the creation the atomic bomb during World War II. Nolan has always favored practical effects over VFX (he even blew up a real Boeing 747 for “Tenet”), so it’s no surprise he went the practical route when it came time to film a nuclear weapon explosion.

“I think recreating the Trinity test [the first nuclear weapon detonation, in New Mexico] without the use of computer graphics was a huge challenge to take on,” Nolan said. “Andrew Jackson — my visual effects supervisor, I got him on board early on — was looking at how we could do a lot of the visual elements of the film practically, from representing quantum dynamics and quantum physics to the Trinity test itself, to recreating, with my team, Los Alamos up on a mesa in New Mexico in extraordinary weather, a lot of which was needed for the film, in terms of the very harsh conditions out there — there were huge practical challenges.”

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Happy Winter! I’m back with another upload, very different in style from my normal content. I’ve wanted to do a Mars colonization video for some time, but I wanted to get Far Future Uranus out and work on a couple other things not content-related beforehand. Making this video was pretty fun, surprisingly. I expected far more terrain buggyness than I actually encountered, and the Starships were really fun to fly. Getting good Starship / Super Heavy landing catch shots was a bit tedious, but it ended up looking good in the end. I’ll be back to more normal content (stuff like Far Future Uranus/Beyond Sol) next time. Also, the 1st part of this video (the part synced to Flight Hymn) is obviously inspired by @NessusKSP in his Far Future Saturn video, hats off to him for making some great content with it!

Continue reading “Colonizing MARS with SpaceX Starship in Kerbal Space Program” »

WASHINGTON, Dec 12 (Reuters) — The U.S. Department of Energy on Tuesday will announce that scientists at a national lab have made a breakthrough on fusion, the process that powers the sun and stars that one day could provide a cheap source of electricity, three sources with knowledge of the matter said.

The scientists at Lawrence Livermore National Laboratory in California have achieved a net energy gain for the first time, in a fusion experiment using lasers, one of the people said.

While the results are a milestone in a scientific quest that has been developing since at least the 1930s, the ratio of energy going into the reaction at Livermore to getting energy out of it needs to be about 100 times bigger to create a process producing commercial amounts of electricity, one of the sources said.