High on Life co-creator Justin Roiland explained AI art makes the game feel like a ‘strange alternate dimension’.
Since as far back as Ancient Greece, humans have been fascinated by the solar system. However, Japanese researchers have now collected asteroid data that provides insights into the development of the solar system that earlier scientists such as Ptolemy, Galileo, and Copernicus could only have dreamed of.
Asteroid explorer Hayabusa2, launched in 2014, set out for Ryugu, a carbon-rich C-type asteroid. In 2018, it arrived in the area of Ryugu, conducting a number of remote observations and collecting samples from two locations on the asteroid. Before the launch of Hayabusa2, a research team at Osaka University had been developing a non-destructive method of light element analysis utilizing muons to analyze Ryugu.
So we designed CAR-T cells to produce IL-2 using synNotch. Now, when a CAR-T cell encounters a tumor, it produces IL-2 within the tumor instead of outside it, avoiding causing harm to surrounding healthy cells. Because synNotch is able to bypass the barriers tumors put up, it is able to help T cells amp up and maintain the amount of IL-2 they can make, allowing the T cells to keep functioning even in a hostile microenvironment.
We tested our CAR-T cells modified with synNotch on mice with pancreatic cancer and melanoma. We found that CAR-T cells with synNotch-induced IL-2 were able to produce enough extra IL-2 to overcome the tumors’ defensive barriers and fully activate, completely eliminating the tumors. While all of the mice receiving synNotch modified CAR-T cells survived, none of the CAR-T-only mice did.
Computational modelling of the brain requires accurate representation of the tissues concerned. Mechanical testing has numerous challenges, in particular for low strain rates, like neurosurgery, where redistribution of fluid is biomechanically important. A finite-element (FE) model was generated in FEBio, incorporating a spring element/fluid–structure interaction representation of the pia–arachnoid complex (PAC). The model was loaded to represent gravity in prone and supine positions. Material parameter identification and sensitivity analysis were performed using statistical software, comparing the FE results to human in vivo measurements. Results for the brain Ogden parameters µ, α and k yielded values of 670 Pa, −19 and 148 kPa, supporting values reported in the literature. Values of the order of 1.2 MPa and 7.7 kPa were obtained for stiffness of the pia mater and out-of-plane tensile stiffness of the PAC, respectively. Positional brain shift was found to be non-rigid and largely driven by redistribution of fluid within the tissue. To the best of our knowledge, this is the first study using in vivo human data and gravitational loading in order to estimate the material properties of intracranial tissues. This model could now be applied to reduce the impact of positional brain shift in stereotactic neurosurgery.
Finite-element (FE)-based computational models of the human brain are an increasingly common research tool, with applications ranging from head impact to neurosurgery. Studies considering head impacts are generally concerned with traumatic brain injury (TBI), where a better understanding of the underlying mechanisms is essential for the development of prevention measures [1]. Within neurosurgery, efforts are primarily focused on tumour resection, where loss of cerebrospinal fluid (CSF) and tissue resection are responsible for much of the deformation [2]. Movement and deformation of the intact brain, known as brain shift, is clinically significant in stereotactic neurosurgical procedures such as deep brain stimulation where electrode placement accuracy correlates with patient outcomes [3].
Computations support the 30-year-old idea that supercooled liquid water can undergo a transition between high-and low-density states.
Heat-transport measurements and neutron-scattering spectroscopy probe a form of thermal conduction based on excitations called phasons.
The understanding of how substances conduct heat is of great significance in materials science. It is needed for many important technological applications—from heat management in electronics to temperature control in buildings [1]. Therefore, when an unusual form of thermal transport is identified, materials scientists take notice. Michael Manley of Oak Ridge National Laboratory, Tennessee, and his colleagues have shown that excitations called phasons can provide the main contribution to thermal transport in a material known as fresnoite [2]. Phasons are collective lattice oscillations that occur in certain crystals with an aperiodic lattice structure—fresnoite being one of the best known. The researchers’ demonstration could pave the way for new heat-management strategies.
Thermal conductivity is a measure of a material’s ability to transfer heat. It is a property that we are all abruptly reminded of when we accidentally place our hand on a hot kitchen stove. The temperature gradient between our cooler skin and the hotter surface facilitates a transfer of energy into our hand, resulting in an unpleasant sensation. The notion that different materials conduct heat at different rates is similarly experienced when we perceive the cooling sensation of holding a metal spoon relative to a wooden one.
An increase in genetic regulatory elements explains how modern humans evolved a bigger brain size than other hominins.
Aging remains a primary risk factor for a host of diseases, including leading causes of death. Aging and associated diseases are inherently multifactorial, with numerous contributing factors and phenotypes at the molecular, cellular, tissue, and organismal scales. Despite the complexity of aging phenomena, models currently used in aging research possess limitations. Frequently used in vivo models often have important physiological differences, age at different rates, or are genetically engineered to match late disease phenotypes rather than early causes. Conversely, routinely used in vitro models lack the complex tissue-scale and systemic cues that are disrupted in aging.
