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Investigators at Cedars-Sinai have created a unique and detailed molecular profile of endometriosis to help improve therapeutic options for the millions of women suffering from the disease.

The study is published today in the journal Nature Genetics.

“Endometriosis has been an understudied disease in part because of limited cellular data that has hindered the development of effective treatments. In this study we applied a new technology called single-cell genomics, which allowed us to profile the many different cell types contributing to the disease,” said Kate Lawrenson, Ph.D., an associate professor in the Department of Obstetrics and Gynecology at Cedars-Sinai, and co-senior and corresponding author of the study.

The blobfish was crowned the world’s ugliest animal in 2013 — a title it still defends today. But drop it 9,200 feet below sea level, and the water holds up all that flab like a push-up bra, making the fish a little more handsome.

Researchers have used fruit flies to decipher an unexplained connection between Alzheimer’s disease and a genetic variation, revealing that it causes neurons to die.

The findings from the Walter and Eliza Hall Institute (WEHI)-led team uncover a possible cause of neurodegeneration in the early stages of Alzheimer’s disease and open the door for the future development of new treatments for cognitive diseases.

The study, “An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration,” with collaborators from Australian National University, is published in Scientific Reports.

Working with one of the world’s preeminent thermoelectric materials researchers, a team of researchers in the Clemson Department of Physics and Astronomy and the Clemson Nanomaterials Institute (CNI) has developed a new, fool-proof method to evaluate thermoelectric materials.

Department of Physics and Astronomy Research Assistant Professor Sriparna Bhattacharya, Engineer Herbert Behlow, and CNI Founding Director Apparao Rao collaborated with world-renowned researcher H. J. Goldsmid, professor emeritus at the University of New South Wales (UNSW) in Sydney, Australia, to create a one-stop method for evaluating the efficiency of thermoelectric materials.

Goldsmid is considered by many to be the “father of thermoelectrics” for his pioneering work in thermoelectric materials. Bhattacharya first connected with Goldsmid on LinkedIn, telling him she had confirmed one of his theoretical predictions during her graduate studies at Clemson University.

In today’s digital age, computational tasks have become increasingly complex. This, in turn, has led to an exponential growth in the power consumed by digital computers. Thus, it is necessary to develop hardware resources that can perform large-scale computing in a fast and energy-efficient way.

In this regard, optical computers, which use light instead of electricity to perform computations, are promising. They can potentially provide lower latency and reduced power consumption, benefiting from the parallelism that optical systems have. As a result, researchers have explored various optical computing designs.

For instance, a diffractive optical network is designed through the combination of optics and deep learning to optically perform complex computational tasks such as image classification and reconstruction. It comprises a stack of structured diffractive layers, each having thousands of diffractive features/neurons. These passive layers are used to control light-matter interactions to modulate the input light and produce the desired output. Researchers train the diffractive network by optimizing the profile of these layers using deep learning tools. After the fabrication of the resulting design, this framework acts as a standalone optical processing module that only requires an input illumination source to be powered.

The US Supreme Court on Monday rejected a bid by NSO Group to block a WhatsApp lawsuit accusing the Israeli tech firm of allowing mass cyberespionage of journalists and human rights activists.

The Supreme Court denied NSO’s plea for legal immunity and ruled that the case, which targets the company’s Pegasus software, can continue in a California federal court, a court filing showed.

Pegasus gives its government customers—which have allegedly included Mexico, Hungary, Morocco and India—near-complete access to a target’s device, including their personal data, photos, messages and location.

Ralph Lydic, professor in the UT Department of Psychology, and Dmitry Bolmatov, a research assistant professor in the UT Department of Physics and Astronomy, are part of a UT/ORNL research team studying how bio-inspired materials might inform the design of next-generation computers. Their results, published recently in the Proceedings of the National Academy of Sciences, could have big implications for both edge computing and human health.

Scientists at ORNL and UT discovered an artificial cell membrane is capable of long-term potentiation, or LTP, a hallmark of biological learning and memory. This is the first evidence that a cell membrane alone—without proteins or other biomolecules embedded within it—is capable of LTP that persists for many hours. It is also the first identified nanoscale structure in which memory can be encoded.

“When facilities were shut down as a result of COVID, this led us to pivot away from our usual membrane research,” said John Katsaras, a biophysicist in ORNL’s Neutron Sciences Directorate specializing in neutron scattering and the study of biological membranes at ORNL. “Together with postdoc Haden Scott, we decided to revisit a system previously studied by Pat Collier and co-workers, this time with an entirely different electrical stimulation protocol that we termed ‘training.’”.

A variety of healthy eating patterns are linked to reduced risk of premature death, according to a new study led by Harvard T.H. Chan School of Public Health researchers. They found that participants who scored high on adherence to at least one of four healthy eating patterns were less likely to die during the study period from any cause and less likely to die from cardiovascular disease, cancer, or respiratory disease, compared with people with lower scores. The findings are consistent with the current Dietary Guidelines for America, which recommend multiple healthy eating patterns.

“The Dietary Guidelines for Americans are intended to provide science-based dietary advice that promotes good health and reduces major chronic diseases. Thus, it is critical to examine the associations between DGAs-recommended dietary patterns and long-term health outcomes, especially mortality,” said corresponding author Frank Hu, Fredrick J. Stare Professor of Nutrition and Epidemiology and chair of the Department of Nutrition.

The study will be published online January 9, 2023, in JAMA Internal Medicine.

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