Stephen Wolfram hosts a live and unscripted Ask Me Anything about the history of science and technology for all ages. Find the playlist of Q&A’s here: https://wolfr.am/youtube-sw-qa.
Originally livestreamed at: https://twitch.tv/stephen_wolfram.
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What is behind dark energy—and what connects it to the cosmological constant introduced by Albert Einstein? Two physicists from the University of Luxembourg point the way to answering these open questions of physics.
The universe has a number of bizarre properties that are difficult to understand with everyday experience. For example, the matter we know, consisting of atoms and molecules and other particles, apparently makes up only a small part of the energy density of the universe. The largest contribution, more than two-thirds, comes from “dark energy”—a hypothetical form of energy whose background physicists are still puzzling over.
Moreover, the universe is not only expanding steadily, but also doing so at an ever-faster pace. Both characteristics seem to be connected, because dark energy is also considered a driver of accelerated expansion. Moreover, it could reunite two powerful physical schools of thought: quantum field theory and the general theory of relativity developed by Albert Einstein. But there is a catch: calculations and observations have so far been far from matching. Now two researchers from Luxembourg have shown a way to solve this 100-year-old riddle in a paper published by Physical Review Letters.
We are on twitter, follow us to connect with us — @scholarsregion— Scholarship Region (@scholarsregion) January 13, 2022.
Novak Djokovic, age 35, sometimes hangs out in a pressurized egg to enrich his blood with oxygen and gives pep talks to glasses of water, hoping to purify them with positive thinking before he drinks them. Tom Brady, 45, evangelizes supposedly age-defying supplements, hydration powders and pliability spheres. LeBron James, 38, is said to spend $1.5 million a year on his body to keep Father Time at bay. While most of their contemporaries have retired, all three of these elite athletes remain marvels of fitness. But in the field of modern health science, they’re amateurs compared to Bryan Johnson.
Middle-aged tech centimillionaire Bryan Johnson and his team of 30 doctors say they have a plan to reboot his body.
We spoke with Dr Morgan Levine 2 years ago concerning the remarkable results that she and a team that included Dr David Sinclair had in restoring vision in mice. In that experiment, published in the journal Nature, older mice had tighter optic nerves crushed causing blindness. Then, using a combination of 3 of the 4 Yamanaka cellular programing factors, they were able to restore the mice’s vision by signally the underlying DNA, rebuilding what had been thought to be permanently damaged cells. This was a remarkable result, as it was restoring a damaged organ, essentially a part of the brain, to its original healthy state. When I spoke to Dr Levine about the next step in her research, she mentioned it may be a more complex organ, such as a mouse liver.
But they went further. In the January issue of Cell, Sinclair published results of their ability to age an entire mouse. That is, to signal the epigenome to cause the underlying mouse DNA to behave as if it were much older. They were also able to do the reverse: to take an older mouse and, by signaling the epigenome, bring its cells and organs to the state of a younger mouse. This is a truly remarkable achievement, and it seems to prove Sinclair’s theory that all of our cells have within them a pristine copy of their DNA, and that aging and the disease associated with aging are the result of miscues from the epigenome. If these miscues can be corrected then the cell can be restored, not to a blank stem cell but to its original condition.
I guess we will have more medicine delivered through the nose in the future.
Antibody molecules sprayed into the noses of rats have led to the repair of stroke-like damage in the brain, and it may be because the drugs travelled through nerve cells for smell.
Perceptually-enabled Task Guidance prototypes demonstrated ability to help people complete recipes as a proxy to unfamiliar tasks.
“Perceptually-enabled Task Guidance (PTG) teams demonstrated a recipe for success in early prototypes of super smart #AIassistants that can see what a user sees and hear what they hear to help them accomplish unfamiliar tasks. More: https://www.darpa.mil/news-events/2023-01-25”
@AuroraFlightSci will design a full-scale X-plane that relies solely on changes in air flow for in-flight maneuvers. #ActiveFlowControl #XPlane More: https://www.darpa.mil/news-events/2023-01-17
