Lifeboat Foundation

Restraining or slowing ageing hallmarks at the cellular level have been proposed as a route to increased organismal lifespan and healthspan. Consequently, there is great interest in anti-ageing drug discovery. However, this currently requires laborious and lengthy longevity analysis. Here, we present a novel screening readout for the expedited discovery of compounds that restrain ageing of cell populations in vitro and enable extension of in vivo lifespan.

Using Illumina methylation arrays, we monitored DNA methylation changes accompanying long-term passaging of adult primary human cells in culture. This enabled us to develop, test, and validate the CellPopAge Clock, an epigenetic clock with underlying algorithm, unique among existing epigenetic clocks for its design to detect anti-ageing compounds in vitro. Additionally, we measured markers of senescence and performed longevity experiments in vivo in Drosophila, to further validate our approach to discover novel anti-ageing compounds. Finally, we bench mark our epigenetic clock with other available epigenetic clocks to consolidate its usefulness and specialisation for primary cells in culture.

We developed a novel epigenetic clock, the CellPopAge Clock, to accurately monitor the age of a population of adult human primary cells. We find that the CellPopAge Clock can detect decelerated passage-based ageing of human primary cells treated with rapamycin or trametinib, well-established longevity drugs. We then utilise the CellPopAge Clock as a screening tool for the identification of compounds which decelerate ageing of cell populations, uncovering novel anti-ageing drugs, torin2 and dactolisib (BEZ-235). We demonstrate that delayed epigenetic ageing in human primary cells treated with anti-ageing compounds is accompanied by a reduction in senescence and ageing biomarkers. Finally, we extend our screening platform in vivo by taking advantage of a specially formulated holidic medium for increased drug bioavailability in Drosophila. We show that the novel anti-ageing drugs, torin2 and dactolisib (BEZ-235), increase longevity in vivo.

Mind-blowing experiments are bringing ancient cosmic conditions into modern labs.

A team of astronomers has identified a temperate exoplanet as a promising super-Earth ice or water world.

The findings, led by Université de Montréal, show that the habitable zone exoplanet, LHS 1,140 b, is not likely a mini-Neptune, a small so-called gas giant—large planets composed mostly of gas—with a thick hydrogen-rich atmosphere. The planet, located about 48 light-years away in the constellation Cetus, emerges as one of the most promising habitable zone exoplanet candidates known, potentially harboring an atmosphere and even a liquid water ocean.

Data from the James Webb Space Telescope (JWST) were collected in December 2023 and added to previous data from other space telescopes Spitzer, Hubble, and TESS to solidify this result, accepted for publication in The Astrophysical Journal Letters this week and currently available on the arXiv preprint server.

Dr. Mark Holley, a distinguished underwater archaeology professor at Northwestern Michigan University, recently unearthed a prehistoric structure in the bay that has drawn comparisons to England’s iconic Stonehenge. Located approximately 40 feet beneath Lake Michigan’s surface, this remarkable find is poised to transform our understanding of the region’s ancient history.

The submerged stones, although smaller than those at Stonehenge, appear to be meticulously arranged. These stones, varying in size from basketballs to compact cars, form a meandering line over a mile long. Among them, a particularly notable rock stands out. It measures three and a half to four feet tall and five feet wide, and features a carving of a mastodon—a testament to an era when these majestic creatures roamed the Earth.

The stones are estimated to be around 9,000 years old, predating Stonehenge by about 4,000 years. This period follows the end of the Ice Age and the formation of Grand Traverse Bay, when the lake bed had not yet been submerged.

Researchers have devised a passive thermal regulation mechanism using common materials that selectively manage radiant heat, providing a sustainable way to significantly improve building energy efficiency and comfort.

Engineers at Princeton and UCLA have developed a passive mechanism to cool buildings in the summer and warm them in the winter.

In an article recently published in the journal Cell Reports Physical Science, they report that by restricting radiant heat flows between buildings and their environment to specific wavelengths, coatings engineered from common materials can achieve energy savings and thermal comfort that goes beyond what traditional building envelopes can achieve.

Each Monday, I pick out North America’s celestial highlights for the week ahead (which also apply to mid-northern latitudes in the northern hemisphere).

The night sky has a visiting comet flaunting its faint tail for stargazers this summer.

The comet 13P/Olbers will make its closest approach to Earth later this month, according to NASA’s Jet Propulsion Laboratory.

The comet orbits the sun every 25,400 days. That’s about every 70 years – 69.54 to be exact. It was last be seen from Earth in 1956.

A research team has constructed a coherent superposition of quantum evolution with two opposite directions in a photonic system and confirmed its advantage in characterizing input-output indefiniteness. The study was published in Physical Review Letters.

The notion that time flows inexorably from the past to the future is deeply rooted in people’s mind. However, the laws of physics that govern the motion of objects in the microscopic world do not deliberately distinguish the direction of time.

To be more specific, the basic equations of motion of both classical and quantum mechanics are reversible, and changing the direction of the time coordinate system of a dynamical process (possibly along with the direction of some other parameters) still constitutes a valid evolution process.

Longtime readers know that I’ve made a bit of an effort to help people understand, and perhaps even grow to respect, the Everett or Many-Worlds Interpretation of Quantum Mechanics (MWI). I’ve even written papers about it. It’s a controversial idea and far from firmly established, but it’s a serious one, and deserves serious discussion.