Lifeboat Foundation

Currently, so-called “oncolytic viruses” such as herpes are used to treat some types of cancer because of their ability to kill cancer cells. But these therapies are not effective with some tumors and their use poses safety concerns, especially in immunosuppressed patients, underscoring the need for safer alternatives, Penaloza-MacMaster said.

In addition to helping clear the tumors, the therapy also helped prevent future cancer in these mice. Healthy mice that were first treated with the LCMV therapy were more resistant to developing tumors later in life.

This phenomenon might be explained by a poorly understood biological process known as “trained immunity.” Trained immunity occurs when a previous infection enhances the immune system’s ability to respond to different diseases in the future. For example, studies have shown that children who received the tuberculosis (TB) vaccine exhibit improved protection against other microorganisms, not just TB. This differs from the typical vaccine response, such as with the SARS-CoV-2 vaccine, which primarily protects against this specific virus.

Astronomers are expecting a “new star” to appear in the night sky anytime between now and September in a celestial event that has been years in the making, according to NASA.

“It’s a once-in-a-lifetime event that will create a lot of new astronomers out there, giving young people a cosmic event they can observe for themselves, ask their own questions, and collect their own data,” said Dr. Rebekah Hounsell, an assistant research scientist specializing in nova events at NASA’s Goddard Space Flight Center in Greenbelt, Maryland, in a statement. “It’ll fuel the next generation of scientists.”

The expected brightening event, known as a nova, will occur in the Milky Way’s Corona Borealis, or Northern Crown constellation, which is located between the Boötes and Hercules constellations.

The study offers promising evidence that exercise can counteract age-related changes in the brain, particularly by rejuvenating microglia. The findings contribute to our understanding of how physical activity can benefit cognitive health and open up new avenues for developing interventions to prevent or slow cognitive decline during aging.

“One of the goals is it to encourage elderly to exercise as we have demonstrated that it is possible to reverse some of the negative aspect of ageing on the brain and thereby improve cognitive performance,” Vukovic said. “The other long-term goals is to find ways and treatments to help elicit the beneficial aspect of exercise on the brain in those individual that are unable to exercise or bed-bound.”

The study, “Exercise rejuvenates microglia and reverses T cell accumulation in the aged female mouse brain,” was authored by Solal Chauquet, Emily F. Willis, Laura Grice, Samuel B. R. Harley, Joseph E. Powell, Naomi R. Wray, Quan Nguyen, Marc J. Ruitenberg, Sonia Shah, and Jana Vukovic.

Faithful transfer of quantum states between different parts of a single complex quantum circuit will become more and more important as quantum computing devices grow in size. Here, the authors transfer single-qubit excitations, two-qubit entangled states, and two excitations across a 6 × 6 superconducting qubit device.

What might the orbit of a primordial black hole going in and out of a Sun-like star look like?

In a significant stride forward for the semiconductor industry, a new review paper from the “Shuang-Qing Forum” offers a comprehensive overview of the advancements and strategic roadmap for two-dimensional (2D) materials.

Dr. Adomas Valantinas: “What we’re seeing may be a remnant of an ancient climate cycle on modern Mars, where you had precipitation and maybe even snowfall on these volcanoes in the past.”

How unique is the climate of Mars compared to Earth? This is what a recent study published in Nature Geoscience hopes to address as a team of international researchers investigated how frost could form on the summits of volcanoes that comprise the Tharsis volcanic province on Mars. This study holds the potential to help researchers better understand the present-day water cycle on the Red Planet and could have implications for harnessing some of it for future human exploration, as well.

For the study, the researchers used more than 30,000 images from the European Space Agency’s Trace Gas orbiter and the European Space Agency’s Mars Express orbiter to analyze morning frost on the summits of Olympus Mons (Mars’ tallest volcano and the tallest planetary mountain in the solar system), Arsia and Ascraeus Montes, and Ceraunius Tholus. Additionally, the researchers used climate model simulations to ascertain if water could condense and form at these summits, as well.

Continue reading “First Detection of Frost on Mars’ Equatorial Volcanoes” »

Significance of the work.

CAR T cells are genetically engineered immune cells tailored to respond to a specific molecule found on the surface of tumor cells. These cells are a form of immunotherapy — an approach that harnesses the native ability of the immune system to fight diseases, particularly cancer. CAR T-cell therapy represents a milestone in cancer treatment. It propels cancer therapies beyond traditional chemotherapy and radiation treatments, which are often highly toxic and non-specific.

The four scientists honored with this year’s Warren Alpert Foundation Prize each played key distinct and complementary roles in developing CAR T cells and making their use in the clinic possible. Today, CAR T-cell therapies offer great hope for patients with various B-cell malignancies who have relapsed or failed to respond to other therapies. CAR T cell-based approaches could eventually be used to treat solid tumors, as well as a variety of autoimmune diseases and other conditions.

A Norwegian startup is building massive AI robots to help airlines reduce their carbon emissions, save water, and inspect their planes in a fraction of the time it usually takes.

The challenge: The aviation industry is responsible for about 2.5% of global carbon emissions, and while sustainable jet fuels or electric propulsion systems could one day slash that figure, airlines can reduce their emissions right now — simply by cleaning their planes more often.

Washing an airplane’s exterior reduces air resistance, which means it can decrease the amount of jet fuel a plane needs to burn by up to 2% — while that’s not a huge difference, it can add up when you consider there are about 28,000 commercial jets in the global fleet.