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A new study in mice by scientists at St. Jude Children’s Research Hospital reveals that immune and tumor cells compete over glutamine. The researchers also identified a molecular pathway that could serve as a potential drug target to achieve the same effect.

The findings are published in Nature in an article titled, “SLC38A2 and glutamine signaling in cDC1s dictate anti-tumor immunity.”

“Cancer cells evade T cell-mediated killing through tumor–immune interactions whose mechanisms are not well understood,” the scientists wrote. “Dendritic cells (DCs), especially type-1 conventional DCs (cDC1s), mediate T cell priming and therapeutic efficacy against tumors. DC functions are orchestrated by pattern recognition receptors, although other signals involved remain incompletely defined. Nutrients are emerging mediators of adaptive immunity, but whether nutrients affect DC function or communication between innate and adaptive immune cells is largely unresolved. Here we establish glutamine as an intercellular metabolic checkpoint that dictates tumor–cDC1 crosstalk and licenses cDC1 function in activating cytotoxic T cells.”

China: A recent article published in Clinical, Cosmetic and Investigational Dermatology reports the case of mycobacterium marinum skin infection in the left upper limb of a female patient with chronic idiopathic myelofibrosis during ruxolitinib treatment.

“Our case illustrates the diversity of skin infections that may occur during JAK (Janus kinase) inhibitors treatment, and the need for clinical attention to atypical mycobacterial skin infections cannot be ignored,” Xiaonan Chen, Affiliated Hospital of Weifang Medical University, Weifang, People’s Republic of China, and colleagues wrote in their case study.

Mycobacterium marinum is an atypical bacterium, and skin infections that result from it are relatively rare, usually occurring in homemakers who clean and prepare fish for food and workers engaged in seafood processing. The infection often occurs after fish spines, scales, etc., puncture the skin. The JAK/STAT signalling pathway is closely linked with the human immune response to infections. Therefore, JAK inhibitors may induce and exacerbate various conditions in clinical practice.

A suggestion from a stranger prompted Jewel Johnson to seek treatment for triple-negative breast cancer at MD Anderson. After being introduced to integrative medicine services, she knew she’d made the right choice.

Computers possess two remarkable capabilities with respect to images: They can both identify them and generate them anew. Historically, these functions have stood separate, akin to the disparate acts of a chef who is good at creating dishes (generation), and a connoisseur who is good at tasting dishes (recognition).

Yet, one can’t help but wonder: What would it take to orchestrate a harmonious union between these two distinctive capacities? Both chef and connoisseur share a common understanding in the taste of the food. Similarly, a unified vision system requires a deep understanding of the visual world.

Now, researchers in MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) have trained a system to infer the missing parts of an image, a task that requires deep comprehension of the image’s content. In successfully filling in the blanks, the system, known as the Masked Generative Encoder (MAGE), achieves two goals at the same time: accurately identifying images and creating new ones with striking resemblance to reality.

Shah, the 31-year-old CEO and founder of Bengaluru-based Duukan, which helps merchants to set up online stores and sell products digitally, posted that “We had to layoff 90% of our support team because of this AI chatbot. Tough? Yes. Necessary? Absolutely.”

We had to layoff 90% of our support team because of this AI chatbot.

Tough? Yes. Necessary? Absolutely.

Simply the smell of seafood can make those with an allergy to it violently ill—and therefore more likely to avoid it. The same avoidance behavior is exhibited by people who develop food poisoning after eating a certain meal.

Scientists have long known that the immune system played a key role in our reactions to allergens and pathogens in the environment, but it was unclear whether it played any role in prompting these types of behaviors towards allergic triggers.

According to Yale-led research published July 12 in the journal Nature, it turns out that the immune system plays a crucial role in changing our behaviors.

Two studies found factors on the male Y chromosome that lead to aggressive tumor growth.

A national study, led by researchers at Tufts Medical Center, has found whole genome sequencing (WGS) to be nearly twice as effective as a targeted gene sequencing test at identifying abnormalities responsible for genetic disorders in newborns and infants. The Genomic Medicine in Ill Infants and Newborns (GEMINI) study did, however, find that time to results was longer when carrying out WGS, when compared with a commercially available targeted neonatal gene-sequencing test.

“More than half of the babies in our study had a genetic disorder that would have remained undetected at most hospitals across the country if not for genome sequencing technologies,” said Jonathan Davis, MD, chief of newborn medicine at Tufts Medical Center and co-principal investigator of the study. “Successfully diagnosing an infant’s genetic disorder as early as possible helps ensure they receive the best medical care. This study shows that WGS, while still imperfect, remains the gold standard for accurate diagnosis of genetic disorders in newborns and infants.”

The study, “A Comparative Analysis of Rapid Whole Genomic Sequencing and a Targeted Neonatal Gene Panel in Infants with a Suspected Genetic Disorder: The Genomic Medicine for Ill Neonates and Infants (GEMINI) Study,” is reported in The Journal of the American Medical Association (J AMA).

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