Lifeboat Foundation

Ribonucleic acid (RNA) is a molecule which is present in cells and made of genetic material to help build proteins necessary for cell function. RNA provides a template for the construction of proteins and is essential for cell and organism life. Immune cells rely on these proteins, including CD8⁺ or cytotoxic T cells which are responsible for killing invading pathogens. Importantly, cytotoxic T cells are a major component of the memory immune response. A pool of T cells specifically designed to recognize an invader is stored for future invasion of that particular pathogen. For example, once these cells are exposed to an invading antigen or protein, the immune system will expand T cells specific to that antigen and remember the antigen next time it enters the body. Vaccines work in a similar way by introducing a foreign antigen to the body, so the immune system is ready if the pathogen ever enters your body in the future. Only a small set of T cells that expand survive and it is unclear how this process occurs.

Recently a team of researchers at the University of Massachusetts Amherst (UMass) demonstrated that a single strand of RNA governs a T cells ability to recognize and kill tumors. The single strand of RNA is known as let-7 and is a microRNA, which is responsible for gene expression regulation. The recent discovery may improve vaccine development and cellular memory to enhance immunotherapy against cancers. Immunotherapy is a general term referring to cancer therapies that try to activate the immune system to kill the tumor compared to other drugs that try to directly kill the tumor with chemicals, such as chemotherapy.

The report published in Nature Communications identified that the microRNA, let-7, may enhance memory of T cells. Researchers led by Dr. Leonid Pobezinsky, Associate Professor of Veterinary and Animal Sciences at UMass, further built on our understanding of how T cells form immune memory. Pobezinsky and colleagues found that a small piece of microRNA that has been present throughout evolution is expressed in memory cells. Additionally, they found that more let-7 a cell has, the more likely that cell will recognize a cancer cell and kill it. The increased let-7 also indicates that the cell will turn into a memory cell after being exposed to an antigen. The regulation of enhanced memory T cells by let-7 is an integral process key to fight infections. This is a critical finding, especially because memory cells retain stem-like characteristics and can survive for decades.

Given the staggering pace of generative AI development, it’s no wonder that so many executives are tempted by the possibilities of AI, concerned about finding and retaining qualified workers, and humbled by recent market corrections or missed analyst expectations. They envision a future of work without nearly as many people as today. But this is a miscalculation. Leaders, understandably concerned about missing out on the next wave of technology, are unwittingly making risky bets on their companies’ futures. Here are steps every leader should take to prepare for an uncertain world where generative AI and human workforces coexist but will evolve in ways that are unknowable.

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A framework for making plans in the midst of great uncertainty.

That’s one way to talk about other human beings.

As writer Elizabeth Weil notes in a new profile of OpenAI CEO Sam Altman in New York Magazine, the powerful AI executive has a disconcerting penchant for using the term “median human,” a phrase that seemingly equates to a robotic tech bro version of “Average Joe.”

Altman’s hope is that artificial general intelligence (AGI) will have roughly the same intelligence as a “median human that you could hire as a co-worker.”

Surge in allergic disorders unexplained by the hygiene hypothesis, challenging assumptions about early-life microbial exposure and its role in allergies. | Health And Medicine.

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The Anatomy of Pain.

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More than 400 years ago, Galileo showed that many everyday phenomena—such as a ball rolling down an incline or a chandelier gently swinging from a church ceiling—obey precise mathematical laws. For this insight, he is often hailed as the founder of modern science. But Galileo recognized that not everything was amenable to a quantitative approach. Such things as colors, tastes and smells “are no more than mere names,” Galileo declared, for “they reside only in consciousness.” These qualities aren’t really out there in the world, he asserted, but exist only in the minds of creatures that perceive them. “Hence if the living creature were removed,” he wrote, “all these qualities would be wiped away and annihilated.”

Since Galileo’s time the physical sciences have leaped forward, explaining the workings of the tiniest quarks to the largest galaxy clusters. But explaining things that reside “only in consciousness”—the red of a sunset, say, or the bitter taste of a lemon—has proven far more difficult. Neuroscientists have identified a number of neural correlates of consciousness —brain states associated with specific mental states—but have not explained how matter forms minds in the first place. As philosopher David Chalmers asked: “How does the water of the brain turn into the wine of consciousness?” He famously dubbed this quandary the “hard problem” of consciousness.

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Hey and we are back … this is Max Flow and we will get to know more about the information limitations of psyche.

Neurons are living cells with a metabolism; they need oxygen and glucose to survive, and when they’ve been working hard, we experience fatigue. Every status update we read on social media, every tweet or text message we get from a friend, is competing for resources in our brains.

Continue reading “Mental perception bandwidth — FlowCode Lesson #16 / Flow state training” »

Coverage of the risks and benefits of AI have paid scant attention to how chatbots might affect public health at a time when depression, suicide, anxiety, and mental illness are epidemic in the United States. But mental health experts and the healthcare industry view AI mostly as a promising tool, rather than a potential threat to mental health.

I am the CEO of Sagenext Infotech LLC. I lead the company’s sales, support, and technology front.

Many small businesses are benefiting from adopting cloud technology to their business operations. This technology is becoming more affordable and accessible, and it’s expected to grow into a trillion-dollar industry by 2028. To remain relevant, retain clients and improve growth, small businesses should fully adopt cloud technology.

Small-business cloud transformation involves the use of cloud technology to transition significant areas of a business in order to add benefits offered by the software or technology to the business.