Lifeboat Foundation

Rayleigh scattering enhanced nanoparticle-doped optical fibers, for distributed sensing applications, is a new technology that offers unique advantages to optical fiber community. However, the existing fabrication technology, based on in situ grown alkaline earth nanoparticles, is restricted to few compositions and exhibit a great dependence on many experimental conditions. Moreover, there is still several uncertainties about the effect of drawing process on the nanoparticle characteristics and its influence on the scattering enhancement and the induced optical loss. In this work, we shed light on all these issues that prevent the progress in the field and demonstrate the suitability of doping optical fibers with YPO4 nanocrystals for developing tunable Rayleigh scattering enhanced nanoparticle-doped optical fibers.

In the study, published August 8, 2023 in Cell Reports, the researchers demonstrate that transplanting hematopoietic stem and progenitor cells was effective in rescuing multiple signs and symptoms of Alzheimer’s in a mouse model of the disease. Mice that received healthy hematopoietic stem cells showed preserved memory and cognition, reduced neuroinflammation and significantly less β-amyloid build-up compared to other Alzheimer’s mice.

Future studies will further explore how the healthy transplanted cells produced such significant improvements, and whether similar transplant strategies can be used to alleviate Alzheimer’s symptoms in humans.

“Alzheimer’s disease poses a major emotional and economic burden on our society, yet there is no effective treatment available,” said Cherqui. “We are excited to see such promising preclinical results from hematopoietic stem cell therapy and look forward to developing a new therapeutic approach for this devastating disease.”

Continue reading “Stem Cell Therapy Rescues Symptoms of Alzheimer’s Disease” »

However, there is currently no base editor to directly edit G or T, since deamination of G rarely causes base conversion, while T lacks amino groups, making it a challenge to overcome the limitation and develop a new class of base editors. Therefore, there is still a need to edit G or T in many cases.

HuidaGene Therapeutics, a clinical-stage genome-editing company, says the National Science Review has published data from its study of the world’s first DNA base editor converting guanine to cytosine/thymine (pyrimidine), or G-to-Y.

The company has filed an international patent application for the glycosylase-based guanine base editor (gGBE) and owns the exclusive global rights to the underlying patent.

Continue reading “HuidaGene Therapeutics creates world’s first ‘G to Y’ DNA base-editor” »

A new study led by investigators from Mass General Brigham has found that ChatGPT was about 72 percent accurate in overall clinical decision making, from coming up with possible diagnoses to making final diagnoses and care management decisions. The large-language model (LLM) artificial intelligence chatbot performed equally well in both primary care and emergency settings across all medical specialties. The research team’s results are published in the Journal of Medical Internet Research.

Our paper comprehensively assesses decision support via ChatGPT from the very beginning of working with a patient through the entire care scenario, from differential diagnosis all the way through testing, diagnosis, and management. No real benchmarks exists, but we estimate this performance to be at the level of someone who has just graduated from medical school, such as an intern or resident. This tells us that LLMs in general have the potential to be an augmenting tool for the practice of medicine and support clinical decision making with impressive accuracy.

Summary: Researchers successfully sequenced the entire Y chromosome, previously considered the most elusive part of the human genome.

This feat enhances DNA sequencing accuracy for this chromosome, aiding the identification of genetic disorders. Using state-of-the-art technologies, the team pieced together over 62 million letters of genetic code.

This breakthrough, in tandem with the previous reference genome T2T-CHM13, offers the first complete genome for those with a Y chromosome.

Shares of Taiwan Semiconductor Manufacturing Corp, which manufactures all of Nvidia’s advanced AI semiconductors climbed as much as 1.81%

Mezli chef Eric Minnich designed a menu for both diner’s delight and ease of robotic cooking.

The only areas where AI is flourishing are shamming, spamming & scamming.

A new efficient system of cancer treatment using vitamin k3 (Vk3)-loaded copper zinc ferrite nanoparticles having therapeutic capabilities, could benefit millions of cancer patients worldwide.

With the ever-increasing prevalence of cancer cases worldwide, newer approaches to cancer therapy are increasingly needed to tackle the problem. Since conventional cancer therapies such as chemotherapy, radiation therapy and surgery have significant drawbacks such as resistance to chemotherapeutic drugs, adverse effects and lower efficacy, development of nanotherapies that can target hypoxic (when oxygen is not available in sufficient amounts at the tissue level) tumors, with minimum side-effects is necessary.

At present, magnetic hyperthermia-based cancer therapy (MHCT) therapy has been shown to be therapeutic. However, in most cases, it is not as effective due to the generation of lower levels of reactive oxygen species (ROS) in a hypoxic tumor microenvironment (TME) and low heat transmission.