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“Focus has been on how cells become mechanosensitive, how cell adhesion became mechanosensitive through the recruitment of mechanosensitive proteins like talin, vinculin, and also other proteins,” said Sangyoon Han, a mechanobiologist at Michigan Technological University who was not involved in the study. “But not many studies were around to tell if there is any kind of premechanosensitive processes that act as a seed for the original binding of this mechanosensitive binding.”

Cooper’s team imaged adhesion formation at the cell surface interface using total internal reflection (TIRF) microscopy and observed that activated Cas clustered at this site almost a full minute before mechanosensing proteins arrived or β1 integrin was activated. They depleted Cas with siRNA and inactivated it to determine this protein’s role in the developing adhesion site. “When we remove Cas from cells, or inhibit its phosphorylation, or inhibit stuff downstream of Cas, the integrin clustering doesn’t really happen,” Cooper said. The Cas-depleted cells attached poorly to surfaces and were immobile.

Finally, the group identified a positive feedback loop between Cas and Rac1, which drives actin polymerization and is important in forming focal complexes that promoted cell adhesion formation.^5,6 Cas phosphorylation activated Rac1, which in turn generated reactive oxygen species, which promoted additional Cas activation. Cas degradation regulated this loop.

The sci-fi dream that gardens and parks would one day glow like Pandora, the alien moon in Avatar, is decades old. Early attempts to splice genes into plants to make them glow date back to the 1980s, but experiments emitted little light and required special food.

Then in 2020, scientists made a breakthrough. Adding genes from luminous mushrooms yielded brightly glowing specimens that needed no special care. The team has refined the approach—writing last month they’ve increased their plants’ luminescence as much as 100-fold—and spun out a startup called Light Bio to sell them.

Light Bio received USDA approval in September and this month announced the first continuously glowing plant, named the firefly petunia, is officially available for purchase in the US. The petunias look and grow like their ordinary cousins—green leaves, white flowers—but after sunset, they glow a gentle green. The company is selling the plants for $29 on its website and says a crop of 50,000 will ship in April.

Summary: Researchers developed an innovative AI tool, DeepGO-SE, that excels in predicting the functions of unknown proteins, marking a significant advance in bioinformatics. Leveraging large language models and logical entailment, this tool can deduce molecular functions even for proteins without existing database matches, offering a groundbreaking approach to understanding cellular mechanisms.

Its precision has placed DeepGO-SE among the top algorithms in an international function prediction competition, demonstrating its potential in drug discovery, metabolic pathway analysis, and beyond. The team aims to apply this tool to explore proteins in extreme environments, opening new doors for biotechnological advancements.

The picture was the result of the first six months of operation of eROSITA (Extended Roentgen Survey with an Imaging Telescope Array), one of two X-ray telescopes that were launched into space in July 2019 aboard the Russian spacecraft SRG (Spectrum-Roentgen-Gamma). eROSITA scans the sky as the spacecraft spins, and collects data over wider angles than are possible for most other X-ray observatories. This enables it to slowly sweep the entire sky every six months.

By an unusual arrangement, the eROSITA team is split into two — with a group based in Germany and one based in Russia — and each has exclusive access to eROSITA data from only half of the sky. The mission was originally intended to cover the sky eight times. But Russia’s full-scale invasion of Ukraine in 2022 led the German government to freeze its collaborations, and eROSITA was put on stand-by. By then, it had completed four full sky scans.

The data that Bulbul and her collaborators have used so far were from their half of the sky, collected during the first scan. Even so, the results are already among the most precise cosmological measurements ever made. It is unclear when the Russia-based group will publish its data and analysis.

According to new research, the core of the Earth is cooling much faster and sooner than originally anticipated — a new mystery that could throw a wrench in our understanding of the planet’s evolution.

To get a better sense of how far along the Earth is in the process, scientists are studying the thermal conductivity of the minerals present in the layer between the planet’s core and mantle. The faster that hot center passes heat to the planet’s outer layers, the faster the Earth is losing the heat present in its core.

In a lab simulation, a team of researchers from ETH Zurich in Switzerland and the Carnegie Institution for Science applied immense amounts of pressure and heat to a mineral called bridgmanite — which is found in the transitional zone between the core and mantle — to simulate the conditions deep below the surface. They then measured its thermal conductivity to get a better sense of the cooling processes at play.

Explore India’s 2024 Health Budget’s focus on technology and AI, with insights into planned healthcare investments, the anticipation for open AI.

Tesla has officially opened orders for its next-generation Powerwall 3 battery on its website, after the company spent much of last year quietly deploying the new hardware.

You can now order a Powerwall 3 from Tesla directly through its website in the U.S., offering updated specs from the previous generation Powerwall 2. Tesla listed the specs for the updated energy storage hardware on its website in September, and it also caught the attention of CEO Elon Musk, who commented on the generation’s improvements after some Powerwall 3 installations had already been spotted.

At the time of writing, the Powerwall 3 doesn’t appear to be available in other North American markets, Canada and Mexico, nor does it appear to be available in Europe or Asia.

Happy birthday, IBM! You’re 100 years old! Or are you?

It’s true that the businesses that formed IBM began in the late 1800s. But it’s also true that a birth occurred in February 1924, with the renaming of the Computing-Tabulating-Recording Co. as the International Business Machines Corp. And a hundred years after that event, it serves as an important reminder that the world of computing and IT that IBM played a pivotal role in building has a longer history than we are likely to think. “Data processing” was coined over a century ago, while “office appliance” was in use in the 1880s. From the 19th century, through the 20th, and into the 21st, IBM was there, making HP, Microsoft, and Apple appear more like children or grandchildren of the IT world; Facebook, Google, and Twitter/X more like great-grandchildren. So let’s take a moment to contemplate the origins of an iconic corporation.