Search results for 'Nicholi': Page 10

Dec 7, 2022

How neurons autonomously regulate their excitability

Posted by in categories: biotech/medical, mobile phones, robotics/AI

Nerve cells can regulate their sensitivity to incoming signals autonomously. A new study led by the University of Bonn has now discovered a mechanism that does just that. The German Center for Neurodegenerative Diseases and the Max Planck Institute for Neurobiology of Behavior were involved in the work. The results have now been published in the journal Cell Reports.

Anyone who has ever sent a voice message with a knows how much the volume matters: Shouting into the microphone results in a distorted and unclear recording. But whispering is not a good idea either—then the result is too quiet and also difficult to understand. That is why sound engineers ensure the perfect sound at every concert and talk show: They regulate each microphone’s gain to match the input signal.

The neurons in the brain can also fine-tune their sensitivity, and even do so autonomously. A new study led by the University of Bonn and the University Hospital Bonn shows how they do this. For this purpose, the participants investigated nerve cell networks that also play a role in vision, hearing and touch. The stimulus first travels to the so-called thalamus, a structure deep in the center of the brain. From there, it is then conducted to the , where it is further processed.

Dec 2, 2022

How touch dampens the brain’s response to painful stimuli

Posted by in category: neuroscience

When we press our temples to soothe an aching head or rub an elbow after an unexpected blow, it often brings some relief. It is believed that pain-responsive cells in the brain quiet down when these neurons also receive touch inputs, say scientists at MIT’s McGovern Institute for Brain Research, who for the first time have watched this phenomenon play out in the brains of mice.

The team’s discovery, reported Nov. 6 in the journal Science Advances, offers researchers a deeper understanding of the complicated relationship between pain and touch and could offer some insights into chronic pain in humans.

“We’re interested in this because it’s a common human experience,” says McGovern investigator Fan Wang. “When some part of your body hurts, you rub it, right? We know touch can alleviate pain in this way.” But, she says, the phenomenon has been very difficult for neuroscientists to study.

Nov 27, 2022

Measuring Potency of Cell and Gene Therapy Products

Posted by in categories: biotech/medical, genetics

CGT are composed of a diverse group of medicinal products. Cell therapies (including ex vivo gene therapies) involve the transfer of cells with a relevant function into the patient. Cells can have different origins, i.e., human (autologous or allogeneic), different differentiation stages, i.e., stem cells or differentiated cells, and can be genetically modified to exert the intended therapeutic effect. In genetically modified cell therapy, a functional transgene is transfected into cells ex vivo using viral (for example, lentiviruses) or nonviral (e.g., electroporation) vectors. Next, the modified cells are administered to the patient where the transgene will promote a therapeutic effect. Examples of these therapies include chimeric antigen receptor (CAR) T cells and genetically modified human stem cells (HSCs).

This article highlights the importance of measuring potency for cell and gene therapies.

Nov 26, 2022

Researchers Say They Are Close To Reversing Aging

Posted by in categories: biotech/medical, life extension

Researchers at Harvard University are investigating whether human genes could reverse the effects of aging. NBC Medical Fellow Dr. Akshay Syal got exclusive access to their lab to discuss the future of how to defy aging.

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Nov 25, 2022

Elon Musk Is Not a Renegade Outsider—He’s a Massive Pentagon Contractor

Posted by in categories: Elon Musk, internet, military

Do you think the image of Elon Musk as a good human being should come to be questioned when he’s a major contractor of the war machine? What are your thoughts?

By Alan MacLeod / MintPress News

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Nov 22, 2022

Fasting triggers stem cell regeneration of damaged, old immune system

Posted by in categories: biotech/medical, life extension

Fasting database:

Recreates the immune system;…Prolonged fasting forces the body to use stores of glucose, fat and ketones, but it also breaks down a significant portion of white blood cells. Longo likens the effect to lightening a plane of excess cargo. During each cycle of fasting, this depletion of white blood cells induces changes that trigger stem cell-based regeneration of new immune system cells. In particular, prolonged fasting reduced the enzyme PKA, an effect previously discovered by the Longo team to extend longevity in simple organisms and which has been linked in other research to the regulation of stem cell self-renewal and pluripotency — that is, the potential for one cell to develop into many different cell types. Prolonged fasting also lowered levels of IGF-1, a growth-factor hormone that Longo and others have linked to aging, tumor progression and cancer risk.

Recreates the immune system (page loads slow)

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Nov 22, 2022

The Kaplan–Yorke conjecture: the Hausdorff dimension of a strange attractor can be computed just from its Lyapunov exponents —

Posted by in category: futurism

That is, just the eigenvalues of a linearized analysis!

Nov 22, 2022

Dr. David Sinclair

Posted by in categories: biological, genetics, life extension

Harvard University geneticist Dr. David Sinclair’s lab is developing a cheek swab test kit so that you can check your biological age at home. You then get updates on how to slow down and reverse your aging.

Find out how fast you’re aging with Tally Health. The future of healthy aging is here.

Nov 16, 2022

Empathy Estimated Using Single-Cell Recordings in Human Brain

Posted by in categories: biotech/medical, neuroscience

Can we measure empathy?

𝐄𝐦𝐩𝐚𝐭𝐡𝐲 𝐄𝐬𝐭𝐢𝐦𝐚𝐭𝐞𝐝 𝐔𝐬𝐢𝐧𝐠 𝐒𝐢𝐧𝐠𝐥𝐞-𝐂𝐞𝐥𝐥 𝐑𝐞𝐜𝐨𝐫𝐝𝐢𝐧𝐠𝐬 𝐢𝐧 𝐇𝐮𝐦𝐚𝐧 𝐁𝐫𝐚𝐢𝐧

𝘼 𝙨𝙩𝙪𝙙𝙮 𝙞𝙣 𝙚𝙇𝙞𝙛𝙚 𝙖𝙣𝙖𝙡𝙮𝙯𝙚𝙙 𝙩𝙝𝙚 𝙘𝙤𝙣𝙩𝙧𝙞𝙗𝙪𝙩𝙞𝙤𝙣 𝙤𝙛 𝙩𝙝𝙚 𝙞𝙣𝙨𝙪𝙡𝙖 𝙞𝙣 𝙤𝙪𝙧 𝙖𝙗𝙞𝙡𝙞𝙩𝙮 𝙩𝙤 𝙪𝙣𝙙𝙚𝙧𝙨𝙩𝙖𝙣𝙙 𝙩𝙝𝙚 𝙥𝙖𝙞𝙣 𝙤𝙛 𝙤𝙩𝙝𝙚𝙧𝙨 𝙗𝙮 𝙧𝙚𝙘𝙤𝙧𝙙𝙞𝙣𝙜 𝙛𝙧𝙤𝙢 𝙚𝙡𝙚𝙘𝙩𝙧𝙤𝙙𝙚𝙨 𝙚𝙢𝙗𝙚𝙙𝙙𝙚𝙙 𝙞𝙣 𝙩𝙝𝙚 𝙝𝙪𝙢𝙖𝙣 𝙗𝙧𝙖𝙞𝙣 𝙩𝙝𝙖𝙩 𝙢𝙚𝙖𝙨𝙪𝙧𝙚𝙙 𝙣𝙚𝙪𝙧𝙤𝙣𝙖𝙡 𝙖𝙘𝙩𝙞𝙫𝙞𝙩𝙮 𝙞𝙣 𝙞𝙣𝙙𝙞𝙫𝙞𝙙𝙪𝙖𝙡 𝙘𝙚𝙡𝙡𝙨 𝙞𝙣 𝙚𝙥𝙞𝙡𝙚𝙥𝙨𝙮 𝙥𝙖𝙩𝙞𝙚𝙣𝙩𝙨 𝙖𝙨 𝙩𝙝𝙚𝙮 𝙫𝙞𝙚𝙬𝙚𝙙 𝙨𝙝𝙤𝙧𝙩 𝙢𝙤𝙫𝙞𝙚𝙨 𝙤𝙛 𝙖𝙣 𝙖𝙘𝙩𝙧𝙚𝙨𝙨 𝙞𝙣 𝙥𝙖𝙞𝙣. 𝙏𝙝𝙚 𝙨𝙩𝙪𝙙𝙮 𝙞𝙢𝙥𝙧𝙤𝙫𝙚𝙨 𝙤𝙪𝙧 𝙪𝙣𝙙𝙚𝙧𝙨𝙩𝙖𝙣𝙙𝙞𝙣𝙜 𝙤𝙛 𝙩𝙝𝙚 𝙞𝙣𝙝𝙚𝙧𝙚𝙣𝙩 𝙙𝙞𝙛𝙛𝙚𝙧𝙚𝙣𝙘𝙚𝙨 𝙞𝙣 𝙥𝙚𝙤𝙥𝙡𝙚’𝙨 𝙖𝙗𝙞𝙡𝙞𝙩𝙮 𝙩𝙤 𝙚𝙢𝙥𝙖𝙩𝙝𝙞𝙯𝙚 𝙖𝙣𝙙 𝙧𝙚𝙖𝙘𝙩 𝙩𝙤 𝙩𝙝𝙚 𝙥𝙖𝙞𝙣 𝙤𝙛 𝙤𝙩𝙝𝙚𝙧𝙨, 𝙖𝙨 𝙬𝙚𝙡𝙡 𝙖𝙨 𝙥𝙤𝙩𝙚𝙣𝙩𝙞𝙖𝙡 𝙢𝙚𝙘𝙝𝙖𝙣𝙞𝙨𝙢𝙨 𝙛𝙤𝙧 𝙩𝙝𝙚 𝙡𝙖𝙘𝙠 𝙤𝙛 𝙚𝙢𝙥𝙖𝙩𝙝𝙮 𝙞𝙣 𝙘𝙚𝙧𝙩𝙖𝙞𝙣 𝙣𝙚𝙪𝙧𝙤𝙥𝙨𝙮𝙘𝙝𝙞𝙖𝙩𝙧𝙞𝙘 𝙘𝙤𝙣𝙙𝙞𝙩𝙞𝙤𝙣𝙨.

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Nov 15, 2022

The Gut Microbiome Helps Social Skills Develop in the Brain

Posted by in categories: biotech/medical, neuroscience

𝐓𝐡𝐞 𝐆𝐮𝐭 𝐌𝐢𝐜𝐫𝐨𝐛𝐢𝐨𝐦𝐞 𝐇𝐞𝐥𝐩𝐬 𝐒𝐨𝐜𝐢𝐚𝐥 𝐒𝐤𝐢𝐥𝐥𝐬 𝐃𝐞𝐯𝐞𝐥𝐨𝐩 𝐢𝐧 𝐭𝐡𝐞 𝐁𝐫𝐚𝐢𝐧

𝙉𝙚𝙬 𝙧𝙚𝙨𝙚𝙖𝙧𝙘𝙝 𝙞𝙣 𝙛𝙞𝙨𝙝 𝙨𝙪𝙜𝙜𝙚𝙨𝙩𝙨 𝙩𝙝𝙖𝙩 𝙜𝙪𝙩 𝙢𝙞𝙘𝙧𝙤𝙗𝙚𝙨 𝙘𝙖𝙣 𝙝𝙖𝙫𝙚 𝙖 𝙘𝙧𝙪𝙘𝙞𝙖𝙡 𝙚𝙖𝙧𝙡𝙮 𝙞𝙣𝙛𝙡𝙪𝙚𝙣𝙘𝙚 𝙤𝙣 𝙩𝙝𝙚 𝙗𝙧𝙖𝙞𝙣’𝙨 𝙨𝙤𝙘𝙞𝙖𝙡 𝙙𝙚𝙫𝙚𝙡𝙤𝙥𝙢𝙚𝙣𝙩.

New research in fish suggests that gut microbes can have a crucial early influence on the brain’s social development.

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